ID   RL27A_BOVIN             Reviewed;         148 AA.
AC   Q56K03; Q2TBT4;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=60S ribosomal protein L27a;
GN   Name=RPL27A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lymphoid epithelium;
RA   Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.;
RT   "Analysis of sequences obtained from constructed full-length bovine cDNA
RT   libraries.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC       large ribonucleoprotein complex responsible for the synthesis of
CC       proteins in the cell. {ECO:0000250|UniProtKB:P46776}.
CC   -!- SUBUNIT: Component of the large ribosomal subunit.
CC       {ECO:0000250|UniProtKB:P46776}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P46776}.
CC   -!- PTM: Hydroxylated on His-39 by MINA. {ECO:0000250|UniProtKB:P46776}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL15 family.
CC       {ECO:0000305}.
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DR   EMBL; AY911324; AAW82092.1; -; mRNA.
DR   EMBL; BC109683; AAI09684.1; -; mRNA.
DR   RefSeq; NP_001019642.1; NM_001024471.2.
DR   AlphaFoldDB; Q56K03; -.
DR   SMR; Q56K03; -.
DR   STRING; 9913.ENSBTAP00000042947; -.
DR   PaxDb; Q56K03; -.
DR   PeptideAtlas; Q56K03; -.
DR   PRIDE; Q56K03; -.
DR   Ensembl; ENSBTAT00000066379; ENSBTAP00000072774; ENSBTAG00000005349.
DR   GeneID; 404190; -.
DR   KEGG; bta:404190; -.
DR   CTD; 6157; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005349; -.
DR   eggNOG; KOG1742; Eukaryota.
DR   GeneTree; ENSGT00390000005534; -.
DR   HOGENOM; CLU_109163_1_0_1; -.
DR   InParanoid; Q56K03; -.
DR   OMA; WGRVGQH; -.
DR   OrthoDB; 1445443at2759; -.
DR   TreeFam; TF313742; -.
DR   Reactome; R-BTA-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-BTA-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-BTA-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-BTA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-BTA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000005349; Expressed in isthmus of fallopian tube and 107 other tissues.
DR   ExpressionAtlas; Q56K03; baseline.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   Gene3D; 4.10.990.10; -; 1.
DR   HAMAP; MF_01341; Ribosomal_L15; 1.
DR   InterPro; IPR036227; L18e/L15P_sf.
DR   InterPro; IPR027386; Rbsml_prot_L15/27a_N.
DR   InterPro; IPR030878; Ribosomal_L15.
DR   InterPro; IPR001196; Ribosomal_L15_CS.
DR   InterPro; IPR021131; Ribosomal_L18e/L15P.
DR   Pfam; PF00828; Ribosomal_L27A; 1.
DR   SUPFAM; SSF52080; SSF52080; 1.
DR   PROSITE; PS00475; RIBOSOMAL_L15; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Hydroxylation; Phosphoprotein; Reference proteome;
KW   Ribonucleoprotein; Ribosomal protein.
FT   CHAIN           1..148
FT                   /note="60S ribosomal protein L27a"
FT                   /id="PRO_0000239270"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..35
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         39
FT                   /note="(3S)-3-hydroxyhistidine"
FT                   /evidence="ECO:0000250|UniProtKB:P46776"
FT   MOD_RES         47
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P46776"
FT   MOD_RES         55
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P46776"
FT   MOD_RES         68
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P46776"
FT   MOD_RES         110
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P46776"
FT   CONFLICT        3
FT                   /note="S -> T (in Ref. 2; AAI09684)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   148 AA;  16577 MW;  D6E11FBC33921056 CRC64;
     MPSRLRKTRK LRGHVSHGHG RIGKHRKHPG GRGNAGGMHH HRINFDKYHP GYFGKVGMRH
     YHLKRNQSFC PTVNLDKLWT LVSEQTRVNA AKNKTGAAPI IDVVRSGYYK VLGKGKLPKQ
     PVIVKAKFFS RRAEEKIKGV GGACVLVA