RL27_PIG
ID RL27_PIG Reviewed; 136 AA.
AC A1XQU5;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=60S ribosomal protein L27;
GN Name=RPL27;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Longissimus dorsi muscle;
RA Cai G., Chen Y., Wang C., Li J., Peng G., Zhang H.;
RT "Generation and analysis of cDNA sequences derived from a porcine skeletal
RT muscle library.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0007744|PDB:3J7O, ECO:0007744|PDB:3J7P, ECO:0007744|PDB:3J7Q, ECO:0007744|PDB:3J7R}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS), FUNCTION, SUBCELLULAR
RP LOCATION, AND SUBUNIT.
RX PubMed=24930395; DOI=10.1016/j.cell.2014.05.024;
RA Voorhees R.M., Fernandez I.S., Scheres S.H., Hegde R.S.;
RT "Structure of the mammalian ribosome-Sec61 complex to 3.4 A resolution.";
RL Cell 157:1632-1643(2014).
CC -!- FUNCTION: Component of the large ribosomal subunit (PubMed:24930395).
CC Required for proper rRNA processing and maturation of 28S and 5.8S
CC rRNAs (By similarity). {ECO:0000250|UniProtKB:P61353,
CC ECO:0000269|PubMed:24930395}.
CC -!- SUBUNIT: Component of the large ribosomal subunit (PubMed:24930395).
CC Interacts with RRP1B (By similarity). Component of the large ribosomal
CC subunit. Interacts with RRP1B. Interacts with DHX33 (By similarity).
CC {ECO:0000250|UniProtKB:P61353, ECO:0000269|PubMed:24930395}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:P61353}. Cytoplasm
CC {ECO:0000269|PubMed:24930395}. Rough endoplasmic reticulum
CC {ECO:0000269|PubMed:24930395}. Note=Detected on cytosolic polysomes (By
CC similarity). Detected in ribosomes that are associated with the rough
CC endoplasmic reticulum (PubMed:24930395). {ECO:0000250|UniProtKB:P61353,
CC ECO:0000269|PubMed:24930395}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL27 family.
CC {ECO:0000305}.
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DR EMBL; DQ629167; ABK55651.1; -; mRNA.
DR RefSeq; NP_001090948.1; NM_001097479.1.
DR PDB; 3J7O; EM; 3.50 A; Z=1-136.
DR PDB; 3J7P; EM; 3.50 A; Z=1-136.
DR PDB; 3J7Q; EM; 3.50 A; Z=1-136.
DR PDB; 3J7R; EM; 3.90 A; Z=1-136.
DR PDBsum; 3J7O; -.
DR PDBsum; 3J7P; -.
DR PDBsum; 3J7Q; -.
DR PDBsum; 3J7R; -.
DR AlphaFoldDB; A1XQU5; -.
DR SMR; A1XQU5; -.
DR STRING; 9823.ENSSSCP00000024028; -.
DR PaxDb; A1XQU5; -.
DR PeptideAtlas; A1XQU5; -.
DR PRIDE; A1XQU5; -.
DR Ensembl; ENSSSCT00000026116; ENSSSCP00000024028; ENSSSCG00000025507.
DR Ensembl; ENSSSCT00005013961; ENSSSCP00005008310; ENSSSCG00005009128.
DR Ensembl; ENSSSCT00025071575; ENSSSCP00025031004; ENSSSCG00025052229.
DR Ensembl; ENSSSCT00035013194; ENSSSCP00035004457; ENSSSCG00035010532.
DR Ensembl; ENSSSCT00045013229; ENSSSCP00045009127; ENSSSCG00045007870.
DR Ensembl; ENSSSCT00045013263; ENSSSCP00045009149; ENSSSCG00045007870.
DR Ensembl; ENSSSCT00050080380; ENSSSCP00050034527; ENSSSCG00050058986.
DR Ensembl; ENSSSCT00055047402; ENSSSCP00055037831; ENSSSCG00055024077.
DR Ensembl; ENSSSCT00065003723; ENSSSCP00065001406; ENSSSCG00065002857.
DR Ensembl; ENSSSCT00070023999; ENSSSCP00070019849; ENSSSCG00070012287.
DR Ensembl; ENSSSCT00070024009; ENSSSCP00070019859; ENSSSCG00070012287.
DR GeneID; 100037995; -.
DR KEGG; ssc:100037995; -.
DR CTD; 6155; -.
DR VGNC; VGNC:99035; RPL27.
DR eggNOG; KOG3418; Eukaryota.
DR GeneTree; ENSGT00390000010721; -.
DR HOGENOM; CLU_067359_0_1_1; -.
DR InParanoid; A1XQU5; -.
DR OMA; HPFPYAI; -.
DR OrthoDB; 1584965at2759; -.
DR Proteomes; UP000008227; Chromosome 12.
DR Proteomes; UP000314985; Chromosome 12.
DR Bgee; ENSSSCG00000025507; Expressed in longissimus lumborum muscle and 43 other tissues.
DR ExpressionAtlas; A1XQU5; baseline and differential.
DR Genevisible; A1XQU5; SS.
DR GO; GO:0098556; C:cytoplasmic side of rough endoplasmic reticulum membrane; IDA:UniProtKB.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0015934; C:large ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd06090; KOW_RPL27; 1.
DR Gene3D; 2.30.30.770; -; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041991; KOW_RPL27.
DR InterPro; IPR038655; L27e_sf.
DR InterPro; IPR001141; Ribosomal_L27e.
DR InterPro; IPR018262; Ribosomal_L27e_CS.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR10497; PTHR10497; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF01777; Ribosomal_L27e; 1.
DR SMART; SM00739; KOW; 1.
DR SUPFAM; SSF50104; SSF50104; 1.
DR PROSITE; PS01107; RIBOSOMAL_L27E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cytoplasm; Endoplasmic reticulum;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..136
FT /note="60S ribosomal protein L27"
FT /id="PRO_0000296385"
FT DOMAIN 5..40
FT /note="KOW"
FT MOD_RES 27
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P61353"
FT MOD_RES 93
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P61353"
SQ SEQUENCE 136 AA; 15798 MW; 73F4151495029A32 CRC64;
MGKFMKPGKV VLVLAGRYSG RKAVIVKNID DGTSDRPYSH ALVAGIDRYP RKVTAAMGKK
KIAKRSKIKS FVKVYNYNHL MPTRYSVDIP LDKTVVNKDV FRDPALKRKA RREAKVKFEE
RYKTGKNKWF FQKLRF
