RL27_RAT
ID RL27_RAT Reviewed; 136 AA.
AC P61354; P08526; Q5BJ97;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=60S ribosomal protein L27;
GN Name=Rpl27;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar; TISSUE=Liver;
RX PubMed=2833393; DOI=10.1111/j.1432-1033.1988.tb13965.x;
RA Tanaka T., Kuwano Y., Ishikawa K., Ogata K.;
RT "Nucleotide sequence of cloned cDNA specific for rat ribosomal protein
RT L27.";
RL Eur. J. Biochem. 173:53-56(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary, and Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the large ribosomal subunit (By similarity).
CC Required for proper rRNA processing and maturation of 28S and 5.8S
CC rRNAs (By similarity). {ECO:0000250|UniProtKB:A1XQU5,
CC ECO:0000250|UniProtKB:P61353}.
CC -!- SUBUNIT: Component of the large ribosomal subunit (By similarity).
CC Interacts with RRP1B (By similarity). Component of the large ribosomal
CC subunit. Interacts with RRP1B. Interacts with DHX33 (By similarity).
CC {ECO:0000250|UniProtKB:A1XQU5, ECO:0000250|UniProtKB:P61353}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:P61353}. Cytoplasm
CC {ECO:0000250|UniProtKB:P61353}. Rough endoplasmic reticulum
CC {ECO:0000250|UniProtKB:A1XQU5}. Note=Detected on cytosolic polysomes
CC (By similarity). Detected in ribosomes that are associated with the
CC rough endoplasmic reticulum (By similarity).
CC {ECO:0000250|UniProtKB:A1XQU5, ECO:0000250|UniProtKB:P61353}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL27 family.
CC {ECO:0000305}.
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DR EMBL; X07424; CAA30313.1; -; mRNA.
DR EMBL; BC058474; AAH58474.1; -; mRNA.
DR EMBL; BC091566; AAH91566.1; -; mRNA.
DR PIR; S00401; R5RT27.
DR RefSeq; NP_071959.1; NM_022514.1.
DR AlphaFoldDB; P61354; -.
DR SMR; P61354; -.
DR BioGRID; 249021; 5.
DR IntAct; P61354; 5.
DR MINT; P61354; -.
DR STRING; 10116.ENSRNOP00000028060; -.
DR iPTMnet; P61354; -.
DR PhosphoSitePlus; P61354; -.
DR SwissPalm; P61354; -.
DR jPOST; P61354; -.
DR PaxDb; P61354; -.
DR PRIDE; P61354; -.
DR Ensembl; ENSRNOT00000028060; ENSRNOP00000028060; ENSRNOG00000020674.
DR GeneID; 64306; -.
DR KEGG; rno:64306; -.
DR UCSC; RGD:621192; rat.
DR CTD; 6155; -.
DR RGD; 621192; Rpl27.
DR eggNOG; KOG3418; Eukaryota.
DR GeneTree; ENSGT00390000010721; -.
DR HOGENOM; CLU_067359_0_1_1; -.
DR InParanoid; P61354; -.
DR OMA; HPFPYAI; -.
DR OrthoDB; 1584965at2759; -.
DR PhylomeDB; P61354; -.
DR TreeFam; TF314648; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P61354; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000020674; Expressed in thymus and 20 other tissues.
DR Genevisible; P61354; RN.
DR GO; GO:0098556; C:cytoplasmic side of rough endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:RGD.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:1990904; C:ribonucleoprotein complex; ISO:RGD.
DR GO; GO:0005840; C:ribosome; IDA:RGD.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:1904044; P:response to aldosterone; IEP:RGD.
DR GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd06090; KOW_RPL27; 1.
DR Gene3D; 2.30.30.770; -; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041991; KOW_RPL27.
DR InterPro; IPR038655; L27e_sf.
DR InterPro; IPR001141; Ribosomal_L27e.
DR InterPro; IPR018262; Ribosomal_L27e_CS.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR10497; PTHR10497; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF01777; Ribosomal_L27e; 1.
DR SMART; SM00739; KOW; 1.
DR SUPFAM; SSF50104; SSF50104; 1.
DR PROSITE; PS01107; RIBOSOMAL_L27E; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Endoplasmic reticulum; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..136
FT /note="60S ribosomal protein L27"
FT /id="PRO_0000126079"
FT DOMAIN 5..40
FT /note="KOW"
FT MOD_RES 27
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P61353"
FT MOD_RES 93
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P61353"
SQ SEQUENCE 136 AA; 15798 MW; 73F4151495029A32 CRC64;
MGKFMKPGKV VLVLAGRYSG RKAVIVKNID DGTSDRPYSH ALVAGIDRYP RKVTAAMGKK
KIAKRSKIKS FVKVYNYNHL MPTRYSVDIP LDKTVVNKDV FRDPALKRKA RREAKVKFEE
RYKTGKNKWF FQKLRF
