RL28_DROME
ID RL28_DROME Reviewed; 144 AA.
AC Q9VZS5; A4V1E2; Q0E8I7;
DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=60S ribosomal protein L28;
GN Name=RpL28; ORFNames=CG12740;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP STRUCTURE BY ELECTRON MICROSCOPY (6.0 ANGSTROMS) OF THE 80S RIBOSOME.
RX PubMed=23636399; DOI=10.1038/nature12104;
RA Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA Wilson D.N., Beckmann R.;
RT "Structures of the human and Drosophila 80S ribosome.";
RL Nature 497:80-85(2013).
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL28 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014296; AAN11546.1; -; Genomic_DNA.
DR EMBL; AE014296; AAN11547.1; -; Genomic_DNA.
DR EMBL; AY071444; AAL49066.1; -; mRNA.
DR RefSeq; NP_001163336.1; NM_001169865.2.
DR RefSeq; NP_001163337.1; NM_001169866.2.
DR RefSeq; NP_647791.2; NM_139534.4.
DR RefSeq; NP_728839.1; NM_168004.2.
DR RefSeq; NP_728840.1; NM_168005.3.
DR RefSeq; NP_728841.2; NM_168006.3.
DR PDB; 4V6W; EM; 6.00 A; Cr=1-144.
DR PDB; 6XU6; EM; 3.50 A; Cr=2-135.
DR PDB; 6XU7; EM; 4.90 A; Cr=2-135.
DR PDB; 6XU8; EM; 3.00 A; Cr=2-135.
DR PDBsum; 4V6W; -.
DR PDBsum; 6XU6; -.
DR PDBsum; 6XU7; -.
DR PDBsum; 6XU8; -.
DR AlphaFoldDB; Q9VZS5; -.
DR SMR; Q9VZS5; -.
DR BioGRID; 63893; 99.
DR IntAct; Q9VZS5; 5.
DR MINT; Q9VZS5; -.
DR STRING; 7227.FBpp0072957; -.
DR PaxDb; Q9VZS5; -.
DR PRIDE; Q9VZS5; -.
DR DNASU; 38397; -.
DR EnsemblMetazoa; FBtr0073095; FBpp0072957; FBgn0035422.
DR EnsemblMetazoa; FBtr0073097; FBpp0072959; FBgn0035422.
DR EnsemblMetazoa; FBtr0073098; FBpp0072960; FBgn0035422.
DR EnsemblMetazoa; FBtr0302300; FBpp0291506; FBgn0035422.
DR EnsemblMetazoa; FBtr0302301; FBpp0291507; FBgn0035422.
DR EnsemblMetazoa; FBtr0306567; FBpp0297522; FBgn0035422.
DR GeneID; 38397; -.
DR KEGG; dme:Dmel_CG12740; -.
DR CTD; 6158; -.
DR FlyBase; FBgn0035422; RpL28.
DR VEuPathDB; VectorBase:FBgn0035422; -.
DR eggNOG; KOG3412; Eukaryota.
DR GeneTree; ENSGT00390000008732; -.
DR HOGENOM; CLU_106801_1_0_1; -.
DR InParanoid; Q9VZS5; -.
DR OMA; MIIRNNN; -.
DR OrthoDB; 1593474at2759; -.
DR PhylomeDB; Q9VZS5; -.
DR Reactome; R-DME-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DME-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-DME-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DME-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-DME-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-DME-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR SignaLink; Q9VZS5; -.
DR BioGRID-ORCS; 38397; 1 hit in 1 CRISPR screen.
DR ChiTaRS; RpL28; fly.
DR GenomeRNAi; 38397; -.
DR PRO; PR:Q9VZS5; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0035422; Expressed in seminal fluid secreting gland and 12 other tissues.
DR ExpressionAtlas; Q9VZS5; baseline and differential.
DR Genevisible; Q9VZS5; DM.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0022626; C:cytosolic ribosome; IDA:FlyBase.
DR GO; GO:0003735; F:structural constituent of ribosome; IDA:FlyBase.
DR GO; GO:0002181; P:cytoplasmic translation; TAS:FlyBase.
DR InterPro; IPR029004; L28e/Mak16.
DR InterPro; IPR002672; Ribosomal_L28e.
DR PANTHER; PTHR10544; PTHR10544; 1.
DR Pfam; PF01778; Ribosomal_L28e; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..144
FT /note="60S ribosomal protein L28"
FT /id="PRO_0000122395"
FT REGION 122..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 144 AA; 16029 MW; 14D5C7866F585113 CRC64;
MATSSHLNWL IIRNNNAFLL KKRDVKKPFS TEPNNLASVS SYRYSGIVHK KTLGVVPAAD
KKGFTAVLKK GKYAQRPAKN TVRVDFKAGP RRSLKKLKNL LIGSKYRKDL TQAALRRASA
VLRSQKPAPV KGKKAEFAKG KKPE
