ATPF2_MOUSE
ID ATPF2_MOUSE Reviewed; 289 AA.
AC Q91YY4; Q8BP08;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=ATP synthase mitochondrial F1 complex assembly factor 2;
DE Flags: Precursor;
GN Name=Atpaf2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-133, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- FUNCTION: May play a role in the assembly of the F1 component of the
CC mitochondrial ATP synthase (ATPase). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ATP5F1A. Interacts with FMC1.
CC {ECO:0000250|UniProtKB:Q8N5M1}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ATP12 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC37311.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAI24077.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK078500; BAC37311.1; ALT_INIT; mRNA.
DR EMBL; AL596090; CAI24077.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC013607; AAH13607.1; -; mRNA.
DR RefSeq; NP_663402.2; NM_145427.2.
DR AlphaFoldDB; Q91YY4; -.
DR SMR; Q91YY4; -.
DR BioGRID; 232949; 5.
DR STRING; 10090.ENSMUSP00000104361; -.
DR iPTMnet; Q91YY4; -.
DR PhosphoSitePlus; Q91YY4; -.
DR EPD; Q91YY4; -.
DR MaxQB; Q91YY4; -.
DR PaxDb; Q91YY4; -.
DR PeptideAtlas; Q91YY4; -.
DR PRIDE; Q91YY4; -.
DR ProteomicsDB; 277091; -.
DR Antibodypedia; 13429; 140 antibodies from 24 providers.
DR DNASU; 246782; -.
DR Ensembl; ENSMUST00000108721; ENSMUSP00000104361; ENSMUSG00000042709.
DR GeneID; 246782; -.
DR KEGG; mmu:246782; -.
DR UCSC; uc007jfv.2; mouse.
DR CTD; 91647; -.
DR MGI; MGI:2180561; Atpaf2.
DR VEuPathDB; HostDB:ENSMUSG00000042709; -.
DR eggNOG; KOG3015; Eukaryota.
DR GeneTree; ENSGT00390000009492; -.
DR InParanoid; Q91YY4; -.
DR OrthoDB; 734341at2759; -.
DR PhylomeDB; Q91YY4; -.
DR TreeFam; TF315138; -.
DR BioGRID-ORCS; 246782; 26 hits in 74 CRISPR screens.
DR ChiTaRS; Atpaf2; mouse.
DR PRO; PR:Q91YY4; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q91YY4; protein.
DR Bgee; ENSMUSG00000042709; Expressed in yolk sac and 197 other tissues.
DR ExpressionAtlas; Q91YY4; baseline and differential.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0033615; P:mitochondrial proton-transporting ATP synthase complex assembly; IBA:GO_Central.
DR Gene3D; 1.10.3580.10; -; 1.
DR Gene3D; 3.30.2180.10; -; 1.
DR InterPro; IPR011419; ATP12_ATP_synth-F1-assembly.
DR InterPro; IPR042272; ATP12_ATP_synth-F1-assembly_N.
DR InterPro; IPR023335; ATP12_ortho_dom_sf.
DR PANTHER; PTHR21013; PTHR21013; 1.
DR Pfam; PF07542; ATP12; 1.
PE 1: Evidence at protein level;
KW Chaperone; Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..40
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 41..289
FT /note="ATP synthase mitochondrial F1 complex assembly
FT factor 2"
FT /id="PRO_0000002419"
FT MOD_RES 133
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
SQ SEQUENCE 289 AA; 33289 MW; F9644CF4189AC466 CRC64;
MWRIYPRLRD RWRGLLDRRL SDPTVSVWPG PAPQPPARAY VPPTERKRFY QNVSISQGEG
GFEINLDHRK LKTPQAKLFT VPSEALAIAV ATEWDSQQDT IKFYTMHLTT LCNTSLDNPT
QRSKDQLIRA AVKFLDTDTI CYRVEEPETL VELQKNEWDP VIEWAEKRYG MEIGSSTSIM
GPSIPTQTRE VLTSHLSSYN MWALQGIEFV VAQLKSMLLT LGLIDLRLTV EQAVLLSRLE
EEYQIQKWGN IEWAHDYELQ ELRARTAAGT LFVHLCSESS TVKHKLLQE
