RL2_STAA8
ID RL2_STAA8 Reviewed; 277 AA.
AC P60430; Q2FW09; Q99S24; Q9AJ03;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-FEB-2004, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=50S ribosomal protein L2 {ECO:0000255|HAMAP-Rule:MF_01320};
GN Name=rplB {ECO:0000255|HAMAP-Rule:MF_01320};
GN OrderedLocusNames=SAOUHSC_02509;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Balaban N.;
RL Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
CC -!- FUNCTION: One of the primary rRNA binding proteins. Required for
CC association of the 30S and 50S subunits to form the 70S ribosome, for
CC tRNA binding and peptide bond formation. It has been suggested to have
CC peptidyltransferase activity; this is somewhat controversial. Makes
CC several contacts with the 16S rRNA in the 70S ribosome.
CC {ECO:0000255|HAMAP-Rule:MF_01320}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit. Forms a bridge to the 30S
CC subunit in the 70S ribosome. {ECO:0000255|HAMAP-Rule:MF_01320}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL2 family.
CC {ECO:0000255|HAMAP-Rule:MF_01320}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF205220; AAK37412.2; -; Genomic_DNA.
DR EMBL; CP000253; ABD31527.1; -; Genomic_DNA.
DR RefSeq; WP_000985472.1; NZ_LS483365.1.
DR RefSeq; YP_500976.1; NC_007795.1.
DR PDB; 4WCE; X-ray; 3.53 A; A=1-277.
DR PDB; 4WF9; X-ray; 3.43 A; A=1-277.
DR PDB; 4WFA; X-ray; 3.39 A; A=1-277.
DR PDB; 4WFB; X-ray; 3.43 A; A=1-277.
DR PDB; 5HKV; X-ray; 3.66 A; A=1-277.
DR PDB; 5HL7; X-ray; 3.55 A; A=1-277.
DR PDB; 5LI0; EM; 3.80 A; D=2-276.
DR PDB; 5ND8; EM; 3.70 A; D=1-277.
DR PDB; 5ND9; EM; 3.70 A; D=1-277.
DR PDB; 5NRG; X-ray; 3.44 A; A=1-277.
DR PDB; 5TCU; EM; 3.90 A; L2=2-275.
DR PDB; 6DDD; EM; 3.10 A; B=1-276.
DR PDB; 6DDG; EM; 3.10 A; B=1-276.
DR PDB; 6HMA; EM; 2.65 A; C=2-275.
DR PDB; 6SJ6; EM; 3.23 A; D=1-277.
DR PDB; 6WQN; EM; 2.90 A; B=1-277.
DR PDB; 6WQQ; EM; 3.10 A; B=1-277.
DR PDB; 6WRS; EM; 3.20 A; B=1-277.
DR PDB; 6WRU; EM; 3.10 A; B=1-277.
DR PDB; 6YEF; EM; 3.20 A; D=1-277.
DR PDB; 7NHL; EM; 3.10 A; G=1-277.
DR PDB; 7NHM; EM; 3.10 A; G=1-277.
DR PDBsum; 4WCE; -.
DR PDBsum; 4WF9; -.
DR PDBsum; 4WFA; -.
DR PDBsum; 4WFB; -.
DR PDBsum; 5HKV; -.
DR PDBsum; 5HL7; -.
DR PDBsum; 5LI0; -.
DR PDBsum; 5ND8; -.
DR PDBsum; 5ND9; -.
DR PDBsum; 5NRG; -.
DR PDBsum; 5TCU; -.
DR PDBsum; 6DDD; -.
DR PDBsum; 6DDG; -.
DR PDBsum; 6HMA; -.
DR PDBsum; 6SJ6; -.
DR PDBsum; 6WQN; -.
DR PDBsum; 6WQQ; -.
DR PDBsum; 6WRS; -.
DR PDBsum; 6WRU; -.
DR PDBsum; 6YEF; -.
DR PDBsum; 7NHL; -.
DR PDBsum; 7NHM; -.
DR AlphaFoldDB; P60430; -.
DR SMR; P60430; -.
DR IntAct; P60430; 2.
DR STRING; 1280.SAXN108_2496; -.
DR EnsemblBacteria; ABD31527; ABD31527; SAOUHSC_02509.
DR GeneID; 3920885; -.
DR GeneID; 66840459; -.
DR KEGG; sao:SAOUHSC_02509; -.
DR PATRIC; fig|93061.5.peg.2264; -.
DR eggNOG; COG0090; Bacteria.
DR HOGENOM; CLU_036235_2_1_9; -.
DR OMA; SCIELRP; -.
DR PRO; PR:P60430; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0016740; F:transferase activity; IEA:InterPro.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 4.10.950.10; -; 1.
DR HAMAP; MF_01320_B; Ribosomal_L2_B; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR022666; Rbsml_prot_L2_RNA-bd_dom.
DR InterPro; IPR014722; Rib_L2_dom2.
DR InterPro; IPR002171; Ribosomal_L2.
DR InterPro; IPR005880; Ribosomal_L2_bac/org-type.
DR InterPro; IPR022669; Ribosomal_L2_C.
DR InterPro; IPR022671; Ribosomal_L2_CS.
DR InterPro; IPR014726; Ribosomal_L2_dom3.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR13691; PTHR13691; 1.
DR Pfam; PF00181; Ribosomal_L2; 1.
DR Pfam; PF03947; Ribosomal_L2_C; 1.
DR PIRSF; PIRSF002158; Ribosomal_L2; 1.
DR SMART; SM01383; Ribosomal_L2; 1.
DR SMART; SM01382; Ribosomal_L2_C; 1.
DR SUPFAM; SSF50104; SSF50104; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR TIGRFAMs; TIGR01171; rplB_bact; 1.
DR PROSITE; PS00467; RIBOSOMAL_L2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW RNA-binding; rRNA-binding.
FT CHAIN 1..277
FT /note="50S ribosomal protein L2"
FT /id="PRO_0000129620"
FT REGION 36..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..277
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 3..5
FT /evidence="ECO:0007829|PDB:6WQN"
FT STRAND 9..15
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 17..19
FT /evidence="ECO:0007829|PDB:6WQN"
FT HELIX 22..24
FT /evidence="ECO:0007829|PDB:4WFB"
FT HELIX 31..33
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 34..36
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 41..43
FT /evidence="ECO:0007829|PDB:6DDD"
FT STRAND 45..47
FT /evidence="ECO:0007829|PDB:4WFA"
FT STRAND 51..53
FT /evidence="ECO:0007829|PDB:6WQN"
FT STRAND 61..63
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 76..82
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 87..89
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 91..96
FT /evidence="ECO:0007829|PDB:6HMA"
FT TURN 97..99
FT /evidence="ECO:0007829|PDB:6DDD"
FT STRAND 101..105
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 107..109
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 114..117
FT /evidence="ECO:0007829|PDB:6WQN"
FT STRAND 118..121
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 125..128
FT /evidence="ECO:0007829|PDB:4WFA"
FT STRAND 129..131
FT /evidence="ECO:0007829|PDB:6HMA"
FT HELIX 132..134
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 140..144
FT /evidence="ECO:0007829|PDB:6HMA"
FT TURN 148..150
FT /evidence="ECO:0007829|PDB:6WQN"
FT STRAND 152..155
FT /evidence="ECO:0007829|PDB:6WQQ"
FT STRAND 157..159
FT /evidence="ECO:0007829|PDB:6SJ6"
FT STRAND 162..167
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 169..175
FT /evidence="ECO:0007829|PDB:6HMA"
FT TURN 177..179
FT /evidence="ECO:0007829|PDB:6SJ6"
FT STRAND 181..185
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 189..193
FT /evidence="ECO:0007829|PDB:6HMA"
FT HELIX 198..202
FT /evidence="ECO:0007829|PDB:6HMA"
FT HELIX 208..213
FT /evidence="ECO:0007829|PDB:6HMA"
FT HELIX 222..224
FT /evidence="ECO:0007829|PDB:6HMA"
FT TURN 227..229
FT /evidence="ECO:0007829|PDB:6WQN"
FT STRAND 230..232
FT /evidence="ECO:0007829|PDB:6WRU"
FT STRAND 236..238
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 243..245
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 251..253
FT /evidence="ECO:0007829|PDB:6DDD"
FT HELIX 265..268
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 269..272
FT /evidence="ECO:0007829|PDB:6HMA"
SQ SEQUENCE 277 AA; 30155 MW; F29296D3EE1E146E CRC64;
MAIKKYKPIT NGRRNMTSLD FAEITKTTPE KSLLKPLPKK AGRNNQGKLT VRHHGGGHKR
QYRVIDFKRN KDGINAKVDS IQYDPNRSAN IALVVYADGE KRYIIAPKGL EVGQIVESGA
EADIKVGNAL PLQNIPVGTV VHNIELKPGK GGQIARSAGA SAQVLGKEGK YVLIRLRSGE
VRMILSTCRA TIGQVGNLQH ELVNVGKAGR SRWKGIRPTV RGSVMNPNDH PHGGGEGRAP
IGRPSPMSPW GKPTLGKKTR RGKKSSDKLI VRGRKKK
