RL30_RAT
ID RL30_RAT Reviewed; 115 AA.
AC P62890; P04645;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=60S ribosomal protein L30;
GN Name=Rpl30;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3840111; DOI=10.1016/0378-1119(85)90007-1;
RA Nakanishi O., Oyanagi M., Kuwano Y., Tanaka T., Nakayama T., Mitsui H.,
RA Nabeshima Y., Ogata K.;
RT "Molecular cloning and nucleotide sequences of cDNAs specific for rat liver
RT ribosomal proteins S17 and L30.";
RL Gene 35:289-296(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. {ECO:0000250|UniProtKB:P62888}.
CC -!- SUBUNIT: Component of the large ribosomal subunit.
CC {ECO:0000250|UniProtKB:P62888}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62888}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL30 family.
CC {ECO:0000305}.
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DR EMBL; K02932; AAA42072.1; -; mRNA.
DR EMBL; BC058471; AAH58471.1; -; mRNA.
DR PIR; B24028; R6RT30.
DR RefSeq; NP_073190.1; NM_022699.3.
DR RefSeq; XP_002727755.1; XM_002727709.4.
DR RefSeq; XP_003752376.1; XM_003752328.4.
DR AlphaFoldDB; P62890; -.
DR SMR; P62890; -.
DR BioGRID; 249178; 7.
DR IntAct; P62890; 4.
DR STRING; 10116.ENSRNOP00000054398; -.
DR iPTMnet; P62890; -.
DR PhosphoSitePlus; P62890; -.
DR jPOST; P62890; -.
DR PaxDb; P62890; -.
DR PRIDE; P62890; -.
DR Ensembl; ENSRNOT00000042688; ENSRNOP00000072453; ENSRNOG00000032825.
DR GeneID; 100362027; -.
DR GeneID; 64640; -.
DR KEGG; rno:100362027; -.
DR KEGG; rno:64640; -.
DR UCSC; RGD:621201; rat.
DR CTD; 6156; -.
DR RGD; 621201; Rpl30.
DR VEuPathDB; HostDB:ENSRNOG00000005975; -.
DR eggNOG; KOG2988; Eukaryota.
DR GeneTree; ENSGT00390000012138; -.
DR HOGENOM; CLU_130502_0_1_1; -.
DR InParanoid; P62890; -.
DR OMA; RPHKIMA; -.
DR OrthoDB; 1503991at2759; -.
DR PhylomeDB; P62890; -.
DR TreeFam; TF300252; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P62890; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000005975; Expressed in thymus and 17 other tissues.
DR Genevisible; P62890; RN.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:RGD.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0042788; C:polysomal ribosome; ISO:RGD.
DR GO; GO:0014069; C:postsynaptic density; ISO:RGD.
DR GO; GO:0005840; C:ribosome; IDA:RGD.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0035368; F:selenocysteine insertion sequence binding; IDA:RGD.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:RGD.
DR GO; GO:0002181; P:cytoplasmic translation; ISO:RGD.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:RGD.
DR GO; GO:0031640; P:killing of cells of another organism; ISO:RGD.
DR GO; GO:0097421; P:liver regeneration; IEP:RGD.
DR GO; GO:1904571; P:positive regulation of selenocysteine incorporation; IDA:RGD.
DR Gene3D; 3.30.1330.30; -; 1.
DR HAMAP; MF_00481; Ribosomal_L30e; 1.
DR InterPro; IPR039109; L30/L30e/YlxQ.
DR InterPro; IPR029064; L30e-like.
DR InterPro; IPR000231; Ribosomal_L30e.
DR InterPro; IPR022991; Ribosomal_L30e_CS.
DR InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR PANTHER; PTHR11449; PTHR11449; 1.
DR PANTHER; PTHR11449:SF12; PTHR11449:SF12; 1.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR SUPFAM; SSF55315; SSF55315; 1.
DR PROSITE; PS00709; RIBOSOMAL_L30E_1; 1.
DR PROSITE; PS00993; RIBOSOMAL_L30E_2; 1.
PE 3: Inferred from homology;
KW Acetylation; Cytoplasm; Isopeptide bond; Phosphoprotein;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein; Ubl conjugation.
FT CHAIN 1..115
FT /note="60S ribosomal protein L30"
FT /id="PRO_0000146123"
FT MOD_RES 10
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P62888"
FT MOD_RES 16
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P62888"
FT MOD_RES 26
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P62888"
FT CROSSLNK 26
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2); alternate"
FT /evidence="ECO:0000250|UniProtKB:P62888"
SQ SEQUENCE 115 AA; 12784 MW; 95186B081E39748C CRC64;
MVAAKKTKKS LESINSRLQL VMKSGKYVLG YKQTLKMIRQ GKAKLVILAN NCPALRKSEI
EYYAMLAKTG VHHYSGNNIE LGTACGKYYR VCTLAIIDPG DSDIIRSMPE QTGEK
