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RL31_DROME
ID   RL31_DROME              Reviewed;         124 AA.
AC   Q9V597; A4UZ96; Q0E9E4;
DT   30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=60S ribosomal protein L31;
GN   Name=RpL31; ORFNames=CG1821;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-102, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18327897; DOI=10.1021/pr700696a;
RA   Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT   "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL   J. Proteome Res. 7:1675-1682(2008).
RN   [5]
RP   STRUCTURE BY ELECTRON MICROSCOPY (6.0 ANGSTROMS) OF THE 80S RIBOSOME.
RX   PubMed=23636399; DOI=10.1038/nature12104;
RA   Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA   Wilson D.N., Beckmann R.;
RT   "Structures of the human and Drosophila 80S ribosome.";
RL   Nature 497:80-85(2013).
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL31 family.
CC       {ECO:0000305}.
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DR   EMBL; AE013599; AAM71073.1; -; Genomic_DNA.
DR   EMBL; AE013599; AAM71074.1; -; Genomic_DNA.
DR   EMBL; AY113508; AAM29513.1; -; mRNA.
DR   RefSeq; NP_610503.1; NM_136659.3.
DR   RefSeq; NP_724804.1; NM_165682.2.
DR   RefSeq; NP_724805.1; NM_165683.2.
DR   PDB; 4V6W; EM; 6.00 A; Cd=1-124.
DR   PDB; 6XU6; EM; 3.50 A; Cd=15-122.
DR   PDB; 6XU7; EM; 4.90 A; Cd=14-124.
DR   PDB; 6XU8; EM; 3.00 A; Cd=15-121.
DR   PDBsum; 4V6W; -.
DR   PDBsum; 6XU6; -.
DR   PDBsum; 6XU7; -.
DR   PDBsum; 6XU8; -.
DR   AlphaFoldDB; Q9V597; -.
DR   SMR; Q9V597; -.
DR   BioGRID; 61819; 110.
DR   DIP; DIP-18938N; -.
DR   IntAct; Q9V597; 18.
DR   STRING; 7227.FBpp0087608; -.
DR   iPTMnet; Q9V597; -.
DR   PaxDb; Q9V597; -.
DR   PRIDE; Q9V597; -.
DR   DNASU; 35988; -.
DR   EnsemblMetazoa; FBtr0088525; FBpp0087608; FBgn0285949.
DR   EnsemblMetazoa; FBtr0088526; FBpp0087609; FBgn0285949.
DR   EnsemblMetazoa; FBtr0088527; FBpp0087610; FBgn0285949.
DR   GeneID; 35988; -.
DR   KEGG; dme:Dmel_CG1821; -.
DR   CTD; 6160; -.
DR   FlyBase; FBgn0285949; RpL31.
DR   VEuPathDB; VectorBase:FBgn0285949; -.
DR   eggNOG; KOG0893; Eukaryota.
DR   GeneTree; ENSGT00950000183030; -.
DR   HOGENOM; CLU_112570_1_1_1; -.
DR   InParanoid; Q9V597; -.
DR   OMA; NMHKRLH; -.
DR   OrthoDB; 1547011at2759; -.
DR   PhylomeDB; Q9V597; -.
DR   Reactome; R-DME-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-DME-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-DME-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-DME-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-DME-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-DME-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   SignaLink; Q9V597; -.
DR   BioGRID-ORCS; 35988; 1 hit in 1 CRISPR screen.
DR   ChiTaRS; RpL31; fly.
DR   GenomeRNAi; 35988; -.
DR   PRO; PR:Q9V597; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   Bgee; FBgn0285949; Expressed in wing disc and 24 other tissues.
DR   Genevisible; Q9V597; DM.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0022626; C:cytosolic ribosome; IDA:FlyBase.
DR   GO; GO:0003735; F:structural constituent of ribosome; IDA:FlyBase.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   CDD; cd00463; Ribosomal_L31e; 1.
DR   Gene3D; 3.10.440.10; -; 1.
DR   InterPro; IPR000054; Ribosomal_L31e.
DR   InterPro; IPR020052; Ribosomal_L31e_CS.
DR   InterPro; IPR023621; Ribosomal_L31e_dom_sf.
DR   PANTHER; PTHR10956; PTHR10956; 1.
DR   Pfam; PF01198; Ribosomal_L31e; 1.
DR   SMART; SM01380; Ribosomal_L31e; 1.
DR   SUPFAM; SSF54575; SSF54575; 1.
DR   PROSITE; PS01144; RIBOSOMAL_L31E; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Phosphoprotein; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein.
FT   CHAIN           1..124
FT                   /note="60S ribosomal protein L31"
FT                   /id="PRO_0000153771"
FT   MOD_RES         102
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000269|PubMed:18327897"
SQ   SEQUENCE   124 AA;  14533 MW;  191543AB701FBE57 CRC64;
     MTKTKGEKIN KSAINEVVTR ECTIHLAKRV HNIGFKKRAP RAIKEIRKFA EREMGTTDVR
     IDTRLNKHIW SKGIRSTPFR IRVRLARRRN DDEDSPNKLY TYVTYVPVST FKNLQTENVE
     SSDD
 
 
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