RL35A_RAT
ID RL35A_RAT Reviewed; 110 AA.
AC P04646;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 13-AUG-1987, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=60S ribosomal protein L35a;
GN Name=Rpl35a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3753935; DOI=10.1111/j.1432-1033.1986.tb09429.x;
RA Tanaka T., Wakasugi K., Kuwano Y., Ishikawa K., Ogata K.;
RT "Nucleotide sequence of cloned cDNA specific for rat ribosomal protein
RT L35a.";
RL Eur. J. Biochem. 154:523-527(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. Required for the proliferation and viability of
CC hematopoietic cells. {ECO:0000250|UniProtKB:P18077}.
CC -!- SUBUNIT: Component of the large ribosomal subunit.
CC {ECO:0000250|UniProtKB:P18077}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P18077}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL33 family.
CC {ECO:0000305}.
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DR EMBL; X03475; CAA27193.1; -; mRNA.
DR EMBL; BC061557; AAH61557.1; -; mRNA.
DR PIR; A25404; R5RT5A.
DR RefSeq; NP_067087.1; NM_021264.3.
DR RefSeq; XP_002727941.1; XM_002727895.5.
DR RefSeq; XP_002727942.1; XM_002727896.5.
DR RefSeq; XP_003752544.1; XM_003752496.4.
DR RefSeq; XP_003752545.1; XM_003752497.4.
DR RefSeq; XP_017445766.1; XM_017590277.1.
DR RefSeq; XP_017453659.1; XM_017598170.1.
DR RefSeq; XP_017453972.1; XM_017598483.1.
DR RefSeq; XP_017459744.1; XM_017604255.1.
DR RefSeq; XP_017459850.1; XM_017604361.1.
DR AlphaFoldDB; P04646; -.
DR SMR; P04646; -.
DR IntAct; P04646; 3.
DR STRING; 10116.ENSRNOP00000039099; -.
DR iPTMnet; P04646; -.
DR PhosphoSitePlus; P04646; -.
DR jPOST; P04646; -.
DR PaxDb; P04646; -.
DR PRIDE; P04646; -.
DR Ensembl; ENSRNOT00000117103; ENSRNOP00000092003; ENSRNOG00000069961.
DR GeneID; 103690996; -.
DR GeneID; 108349682; -.
DR GeneID; 57809; -.
DR KEGG; rno:103690996; -.
DR KEGG; rno:108349682; -.
DR KEGG; rno:57809; -.
DR UCSC; RGD:628793; rat.
DR CTD; 57809; -.
DR RGD; 628793; Rpl35a.
DR VEuPathDB; HostDB:ENSRNOG00000031641; -.
DR VEuPathDB; HostDB:ENSRNOG00000032348; -.
DR VEuPathDB; HostDB:ENSRNOG00000065971; -.
DR VEuPathDB; HostDB:ENSRNOG00000070978; -.
DR eggNOG; KOG0887; Eukaryota.
DR GeneTree; ENSGT00390000016972; -.
DR HOGENOM; CLU_100745_5_0_1; -.
DR InParanoid; P04646; -.
DR OMA; FKRHGRL; -.
DR OrthoDB; 1448743at2759; -.
DR PhylomeDB; P04646; -.
DR TreeFam; TF300104; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P04646; -.
DR Proteomes; UP000002494; Chromosome 12.
DR Bgee; ENSRNOG00000031641; Expressed in skeletal muscle tissue and 8 other tissues.
DR Genevisible; P04646; RN.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR Gene3D; 2.40.10.190; -; 1.
DR HAMAP; MF_00573; Ribosomal_L35Ae; 1.
DR InterPro; IPR038661; L35A_sf.
DR InterPro; IPR001780; Ribosomal_L35A.
DR InterPro; IPR018266; Ribosomal_L35Ae_CS.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR PANTHER; PTHR10902; PTHR10902; 1.
DR Pfam; PF01247; Ribosomal_L35Ae; 1.
DR SUPFAM; SSF50447; SSF50447; 1.
DR PROSITE; PS01105; RIBOSOMAL_L35AE; 1.
PE 3: Inferred from homology;
KW Acetylation; Cytoplasm; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; RNA-binding; tRNA-binding.
FT CHAIN 1..110
FT /note="60S ribosomal protein L35a"
FT /id="PRO_0000192800"
FT MOD_RES 8
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P18077"
FT MOD_RES 63
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:O55142"
FT MOD_RES 63
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:O55142"
SQ SEQUENCE 110 AA; 12554 MW; 126B5E77E75F29F2 CRC64;
MSGRLWCKAI FAGYKRGLRN QREHTALLKI EGVYARDETE FYLGKRCAYV YKAKNNTVTP
GGKPNKTRVI WGKVTRAHGN SGMVRAKFRS NLPAKAIGHR IRVMLYPSRI
