ID   RL35_DANRE              Reviewed;         123 AA.
AC   Q8JHJ1;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=60S ribosomal protein L35;
GN   Name=rpl35;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   TISSUE=Embryo;
RX   PubMed=12006978; DOI=10.1038/ng896;
RA   Golling G., Amsterdam A., Sun Z., Antonelli M., Maldonado E., Chen W.,
RA   Burgess S., Haldi M., Artzt K., Farrington S., Lin S.-Y., Nissen R.M.,
RA   Hopkins N.;
RT   "Insertional mutagenesis in zebrafish rapidly identifies genes essential
RT   for early vertebrate development.";
RL   Nat. Genet. 31:135-140(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION.
RX   PubMed=15138505; DOI=10.1371/journal.pbio.0020139;
RA   Amsterdam A., Sadler K.C., Lai K., Farrington S., Bronson R.T., Lees J.A.,
RA   Hopkins N.;
RT   "Many ribosomal protein genes are cancer genes in zebrafish.";
RL   PLoS Biol. 2:690-698(2004).
CC   -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC       large ribonucleoprotein complex responsible for the synthesis of
CC       proteins in the cell (By similarity). Plays an essential role in early
CC       embryonic development (PubMed:12006978). May act as a haploinsufficient
CC       tumor suppressor (PubMed:15138505). {ECO:0000250|UniProtKB:P42766,
CC       ECO:0000269|PubMed:12006978, ECO:0000269|PubMed:15138505}.
CC   -!- SUBUNIT: Component of the large ribosomal subunit.
CC       {ECO:0000250|UniProtKB:P42766}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P42766}.
CC   -!- DISRUPTION PHENOTYPE: Embryos show various defects including an
CC       inflated hindbrain ventricle and smaller head and eyes. Mutant adults
CC       show an increased incidence of cancer, notably malignant peripheral
CC       nerve sheath tumors. {ECO:0000269|PubMed:12006978}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL29 family.
CC       {ECO:0000305}.
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DR   EMBL; AF506205; AAM34649.1; -; mRNA.
DR   EMBL; BC055640; AAH55640.1; -; mRNA.
DR   RefSeq; NP_775340.1; NM_173233.2.
DR   AlphaFoldDB; Q8JHJ1; -.
DR   SMR; Q8JHJ1; -.
DR   STRING; 7955.ENSDARP00000018594; -.
DR   PaxDb; Q8JHJ1; -.
DR   Ensembl; ENSDART00000009241; ENSDARP00000018594; ENSDARG00000018334.
DR   GeneID; 192299; -.
DR   KEGG; dre:192299; -.
DR   CTD; 11224; -.
DR   ZFIN; ZDB-GENE-020419-2; rpl35.
DR   eggNOG; KOG3436; Eukaryota.
DR   GeneTree; ENSGT00390000016384; -.
DR   HOGENOM; CLU_110381_1_1_1; -.
DR   InParanoid; Q8JHJ1; -.
DR   OMA; VMNQKAR; -.
DR   OrthoDB; 1468839at2759; -.
DR   PhylomeDB; Q8JHJ1; -.
DR   TreeFam; TF314951; -.
DR   Reactome; R-DRE-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-DRE-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-DRE-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-DRE-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-DRE-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-DRE-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:Q8JHJ1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 21.
DR   Bgee; ENSDARG00000018334; Expressed in pharyngeal gill and 28 other tissues.
DR   ExpressionAtlas; Q8JHJ1; baseline and differential.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0043009; P:chordate embryonic development; IMP:ZFIN.
DR   GO; GO:0030218; P:erythrocyte differentiation; IMP:ZFIN.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0051726; P:regulation of cell cycle; IMP:ZFIN.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   Gene3D; 1.10.287.310; -; 1.
DR   HAMAP; MF_00374; Ribosomal_L29; 1.
DR   InterPro; IPR001854; Ribosomal_L29/L35.
DR   InterPro; IPR036049; Ribosomal_L29/L35_sf.
DR   InterPro; IPR018254; Ribosomal_L29_CS.
DR   InterPro; IPR045059; RL35.
DR   PANTHER; PTHR45722; PTHR45722; 1.
DR   Pfam; PF00831; Ribosomal_L29; 1.
DR   SUPFAM; SSF46561; SSF46561; 1.
DR   TIGRFAMs; TIGR00012; L29; 1.
DR   PROSITE; PS00579; RIBOSOMAL_L29; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein; Tumor suppressor.
FT   CHAIN           1..123
FT                   /note="60S ribosomal protein L35"
FT                   /id="PRO_0000130537"
SQ   SEQUENCE   123 AA;  14430 MW;  C2D5439133906269 CRC64;
     MAKIKARDLR GKKKEELLKQ LDDLKVELSQ LRVAKVTGGA ASKLSKIRVV RKSIARVLTV
     INQTQKENLR KFYKGKKYKP LDLRPKKTRA IRRQLTKHEE NLMTKKMQRK SRLYSIRKFA
     VKA