ID   AATR1_DICDI             Reviewed;         481 AA.
AC   Q86AG8; Q55A85;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Aromatic amino acid aminotransferase DDB_G0272014;
DE            EC=2.6.1.57;
GN   ORFNames=DDB_G0272014;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Has aromatic amino acid transaminase activity. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + an aromatic L-alpha-amino acid = an aromatic
CC         oxo-acid + L-glutamate; Xref=Rhea:RHEA:17533, ChEBI:CHEBI:16810,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:73309, ChEBI:CHEBI:84824; EC=2.6.1.57;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000305}.
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DR   EMBL; AAFI02000007; EAL71441.1; -; Genomic_DNA.
DR   RefSeq; XP_645381.1; XM_640289.1.
DR   AlphaFoldDB; Q86AG8; -.
DR   SMR; Q86AG8; -.
DR   STRING; 44689.DDB0168619; -.
DR   PaxDb; Q86AG8; -.
DR   EnsemblProtists; EAL71441; EAL71441; DDB_G0272014.
DR   GeneID; 8618270; -.
DR   KEGG; ddi:DDB_G0272014; -.
DR   dictyBase; DDB_G0272014; -.
DR   eggNOG; KOG0634; Eukaryota.
DR   HOGENOM; CLU_017584_0_6_1; -.
DR   InParanoid; Q86AG8; -.
DR   OMA; LEQTVRM; -.
DR   PhylomeDB; Q86AG8; -.
DR   PRO; PR:Q86AG8; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0080130; F:L-phenylalanine:2-oxoglutarate aminotransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0008483; F:transaminase activity; IBA:GO_Central.
DR   GO; GO:1901605; P:alpha-amino acid metabolic process; IBA:GO_Central.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.640.10; -; 1.
DR   InterPro; IPR004839; Aminotransferase_I/II.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   Pfam; PF00155; Aminotran_1_2; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
PE   3: Inferred from homology;
KW   Aminotransferase; Cytoplasm; Pyridoxal phosphate; Reference proteome;
KW   Transferase.
FT   CHAIN           1..481
FT                   /note="Aromatic amino acid aminotransferase DDB_G0272014"
FT                   /id="PRO_0000331116"
FT   MOD_RES         300
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   481 AA;  55306 MW;  BC8980D006D0139B CRC64;
     MMRSDISNQI SQELNNTNIN LNGKSFNDYK FKEPIKDYSR YLSLRNSTPC QLTEVEISTF
     LASSEILSFG AGIPSKLFFP IKELEFNFNF LGNEKVRLSK EDLDLVQQYS DSPGLPKLRN
     WCKSIQQRHH GLCDPNTPGK EWNLLMTPGS QHALDCLVKA FFNRGDTLIV ERYTYGGMFA
     VTQPSGINFA ACEMDSKGMI PSELDNLLSN WESTHPDLKF PKLIYMIPHG QNPTGILYDM
     ERKEEIYKIA CKFDLLIIED DPHFFLQLDN EIVNGKRVLN KSFLSIDKED RVIRLDTFSK
     FLSSGIRMGF VTTNSKLFGV IAFELNASIF HSSGLTQIAL EKLLTNWGDE KFDSHVNFVQ
     EVLIRKRRET IELLEKHLKG QVEYSVPKAG LYFWVKLLGI DCSYEFVRDV LRHHKVIFGL
     GISSSPNRTI KTPYIRVTFS YLEKEDGEVA FKTLSDCLKD YIKNKKIIKH DEDVTLYNNI
     S