RL35_PIG
ID RL35_PIG Reviewed; 123 AA.
AC Q29361; A1XQU6; A2BD10; Q9BGU2;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=60S ribosomal protein L35;
GN Name=RPL35;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11913794; DOI=10.3109/10425170109084472;
RA Horibe T., Kikuchi M.;
RT "Nucleotide sequence of the porcine 60S ribosomal protein L35 cDNA.";
RL DNA Seq. 12:443-445(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Large white X Landrace X Duroc;
RX PubMed=17416745; DOI=10.1101/gr.6085507;
RA Mikawa S., Morozumi T., Shimanuki S., Hayashi T., Uenishi H., Domukai M.,
RA Okumura N., Awata T.;
RT "Fine mapping of a swine quantitative trait locus for number of vertebrae
RT and analysis of an orphan nuclear receptor, germ cell nuclear factor
RT (NR6A1).";
RL Genome Res. 17:586-593(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Lee H.Y., Cui X.S., Jeong Y.J., Shin M.L., Hwang K.C., Kim N.H.;
RT "Identification of differentially expressed genes in porcine embryos.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Longissimus dorsi muscle;
RA Cai G., Chen Y., Wang C., Li J., Peng G., Zhang H.;
RT "Generation and analysis of cDNA sequences derived from a porcine skeletal
RT muscle library.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-96.
RC TISSUE=Small intestine;
RX PubMed=8672129; DOI=10.1007/s003359900153;
RA Winteroe A.K., Fredholm M., Davies W.;
RT "Evaluation and characterization of a porcine small intestine cDNA library:
RT analysis of 839 clones.";
RL Mamm. Genome 7:509-517(1996).
CC -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. {ECO:0000250|UniProtKB:P42766}.
CC -!- SUBUNIT: Component of the large ribosomal subunit.
CC {ECO:0000250|UniProtKB:P42766}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P42766}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL29 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB055884; BAB32661.1; -; mRNA.
DR EMBL; AP009124; BAF45334.1; -; Genomic_DNA.
DR EMBL; AY550044; AAS55902.1; -; mRNA.
DR EMBL; DQ629168; ABK55652.1; -; mRNA.
DR EMBL; F14766; CAA23237.1; -; mRNA.
DR RefSeq; NP_999491.1; NM_214326.2.
DR PDB; 3J7O; EM; 3.40 A; h=1-123.
DR PDB; 3J7P; EM; 3.50 A; h=1-123.
DR PDB; 3J7Q; EM; 3.40 A; h=1-123.
DR PDB; 3J7R; EM; 3.90 A; h=1-123.
DR PDBsum; 3J7O; -.
DR PDBsum; 3J7P; -.
DR PDBsum; 3J7Q; -.
DR PDBsum; 3J7R; -.
DR AlphaFoldDB; Q29361; -.
DR SMR; Q29361; -.
DR STRING; 9823.ENSSSCP00000005993; -.
DR PaxDb; Q29361; -.
DR PeptideAtlas; Q29361; -.
DR PRIDE; Q29361; -.
DR Ensembl; ENSSSCT00000042194; ENSSSCP00000052105; ENSSSCG00000034227.
DR Ensembl; ENSSSCT00000080911; ENSSSCP00000063069; ENSSSCG00000034227.
DR Ensembl; ENSSSCT00015048117; ENSSSCP00015019093; ENSSSCG00015036242.
DR Ensembl; ENSSSCT00015048280; ENSSSCP00015019180; ENSSSCG00015036242.
DR Ensembl; ENSSSCT00025042268; ENSSSCP00025017990; ENSSSCG00025031064.
DR Ensembl; ENSSSCT00025042332; ENSSSCP00025018019; ENSSSCG00025031064.
DR Ensembl; ENSSSCT00030065195; ENSSSCP00030029780; ENSSSCG00030046747.
DR Ensembl; ENSSSCT00030065211; ENSSSCP00030029788; ENSSSCG00030046747.
DR Ensembl; ENSSSCT00040003504; ENSSSCP00040001068; ENSSSCG00040002830.
DR Ensembl; ENSSSCT00045058878; ENSSSCP00045041199; ENSSSCG00045034378.
DR Ensembl; ENSSSCT00045058943; ENSSSCP00045041258; ENSSSCG00045034378.
DR Ensembl; ENSSSCT00055054790; ENSSSCP00055043713; ENSSSCG00055027677.
DR Ensembl; ENSSSCT00055054832; ENSSSCP00055043750; ENSSSCG00055027677.
DR Ensembl; ENSSSCT00060106823; ENSSSCP00060047252; ENSSSCG00060077566.
DR Ensembl; ENSSSCT00060106846; ENSSSCP00060047267; ENSSSCG00060077566.
DR Ensembl; ENSSSCT00065024912; ENSSSCP00065010165; ENSSSCG00065018751.
DR Ensembl; ENSSSCT00065024921; ENSSSCP00065010172; ENSSSCG00065018751.
DR Ensembl; ENSSSCT00070032952; ENSSSCP00070027515; ENSSSCG00070016719.
DR Ensembl; ENSSSCT00070032956; ENSSSCP00070027519; ENSSSCG00070016719.
DR GeneID; 397598; -.
DR KEGG; ssc:397598; -.
DR CTD; 11224; -.
DR VGNC; VGNC:103164; RPL35.
DR eggNOG; KOG3436; Eukaryota.
DR GeneTree; ENSGT00390000016384; -.
DR HOGENOM; CLU_110381_1_1_1; -.
DR InParanoid; Q29361; -.
DR OMA; VMNQKAR; -.
DR OrthoDB; 1468839at2759; -.
DR TreeFam; TF314951; -.
DR Reactome; R-SSC-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-SSC-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-SSC-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-SSC-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-SSC-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-SSC-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR Proteomes; UP000008227; Chromosome 1.
DR Proteomes; UP000314985; Chromosome 1.
DR Bgee; ENSSSCG00000034227; Expressed in blood and 45 other tissues.
DR Genevisible; Q29361; SS.
DR GO; GO:0098556; C:cytoplasmic side of rough endoplasmic reticulum membrane; IDA:UniProtKB.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0015934; C:large ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 1.10.287.310; -; 1.
DR HAMAP; MF_00374; Ribosomal_L29; 1.
DR InterPro; IPR001854; Ribosomal_L29/L35.
DR InterPro; IPR036049; Ribosomal_L29/L35_sf.
DR InterPro; IPR018254; Ribosomal_L29_CS.
DR InterPro; IPR045059; RL35.
DR PANTHER; PTHR45722; PTHR45722; 1.
DR Pfam; PF00831; Ribosomal_L29; 1.
DR SUPFAM; SSF46561; SSF46561; 1.
DR TIGRFAMs; TIGR00012; L29; 1.
DR PROSITE; PS00579; RIBOSOMAL_L29; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cytoplasm; Isopeptide bond; Phosphoprotein;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein; Ubl conjugation.
FT CHAIN 1..123
FT /note="60S ribosomal protein L35"
FT /id="PRO_0000130534"
FT MOD_RES 19
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P42766"
FT MOD_RES 29
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P42766"
FT MOD_RES 43
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P42766"
FT CROSSLNK 25
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P42766"
FT CONFLICT 14
FT /note="K -> R (in Ref. 4; ABK55652)"
FT /evidence="ECO:0000305"
FT CONFLICT 34
FT /note="A -> G (in Ref. 5; CAA23237)"
FT /evidence="ECO:0000305"
FT CONFLICT 95..96
FT /note="LN -> ST (in Ref. 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 104
FT /note="T -> P (in Ref. 4; ABK55652)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 123 AA; 14550 MW; 73F27D1A903DD8EC CRC64;
MAKIKARDLR GKKKEELLKQ LEDLKVELSQ LRVAKVTGGA ASKLSKIRVV RKSIARVLTV
INQTQKENLR KFYKGKKYKP LDLRPKKTRA MRRRLNKHEE NLKTKKQQRK ERLYPLRKFA
VKA
