RL36L_HUMAN
ID RL36L_HUMAN Reviewed; 106 AA.
AC Q969Q0; Q3B7A5;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=60S ribosomal protein L36a-like;
DE AltName: Full=Large ribosomal subunit protein eL42-like;
GN Name=RPL36AL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3542712; DOI=10.1016/0378-1119(86)90253-2;
RA Davies M.S., Henney A., Ward W.H.J., Craig R.K.;
RT "Characterisation of an mRNA encoding a human ribosomal protein homologous
RT to the yeast L44 ribosomal protein.";
RL Gene 45:183-191(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12490704; DOI=10.1093/nar/gkf696;
RA Uechi T., Maeda N., Tanaka T., Kenmochi N.;
RT "Functional second genes generated by retrotransposition of the X-linked
RT ribosomal protein genes.";
RL Nucleic Acids Res. 30:5369-5375(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P.,
RA Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y.,
RA LaBaer J.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney, and Skeletal muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PROTEIN SEQUENCE OF 29-38 AND 100-106, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=Lung carcinoma;
RA Bienvenut W.V., Vousden K.H., Lukashchuk N.;
RL Submitted (MAR-2008) to UniProtKB.
RN [6]
RP PROTEIN SEQUENCE OF 45-57; 70-78 AND 100-106, METHYLATION AT LYS-53, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RA Bienvenut W.V., Waridel P., Quadroni M.;
RL Submitted (MAR-2009) to UniProtKB.
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- INTERACTION:
CC Q969Q0; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-2877705, EBI-10172290;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:12490704}.
CC -!- MISCELLANEOUS: This gene has no introns in its coding regions, and
CC therefore, was most likely produced by retrotransposition of the
CC original X-linked gene during evolution.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL42 family.
CC {ECO:0000305}.
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DR EMBL; M15661; AAA36589.1; -; mRNA.
DR EMBL; AB063609; BAC19836.1; -; mRNA.
DR EMBL; CR542166; CAG46963.1; -; mRNA.
DR EMBL; BC000741; AAH00741.1; -; mRNA.
DR EMBL; BC003145; AAH03145.1; -; mRNA.
DR EMBL; BC070207; AAH70207.1; -; mRNA.
DR EMBL; BC107716; AAI07717.1; -; mRNA.
DR CCDS; CCDS9689.1; -.
DR PIR; A25560; R6HU36.
DR RefSeq; NP_000992.1; NM_001001.4.
DR AlphaFoldDB; Q969Q0; -.
DR SMR; Q969Q0; -.
DR BioGRID; 112085; 310.
DR IntAct; Q969Q0; 56.
DR MINT; Q969Q0; -.
DR STRING; 9606.ENSP00000346012; -.
DR GlyGen; Q969Q0; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q969Q0; -.
DR PhosphoSitePlus; Q969Q0; -.
DR SwissPalm; Q969Q0; -.
DR BioMuta; RPL36AL; -.
DR DMDM; 57013007; -.
DR EPD; Q969Q0; -.
DR jPOST; Q969Q0; -.
DR MassIVE; Q969Q0; -.
DR MaxQB; Q969Q0; -.
DR PeptideAtlas; Q969Q0; -.
DR PRIDE; Q969Q0; -.
DR ProteomicsDB; 75813; -.
DR TopDownProteomics; Q969Q0; -.
DR Antibodypedia; 61338; 150 antibodies from 20 providers.
DR DNASU; 6166; -.
DR Ensembl; ENST00000298289.7; ENSP00000346012.5; ENSG00000165502.7.
DR GeneID; 6166; -.
DR KEGG; hsa:6166; -.
DR MANE-Select; ENST00000298289.7; ENSP00000346012.5; NM_001001.5; NP_000992.1.
DR UCSC; uc001wwq.4; human.
DR CTD; 6166; -.
DR DisGeNET; 6166; -.
DR GeneCards; RPL36AL; -.
DR HGNC; HGNC:10346; RPL36AL.
DR HPA; ENSG00000165502; Low tissue specificity.
DR MIM; 180469; gene.
DR neXtProt; NX_Q969Q0; -.
DR OpenTargets; ENSG00000165502; -.
DR PharmGKB; PA34732; -.
DR VEuPathDB; HostDB:ENSG00000165502; -.
DR GeneTree; ENSGT00940000161656; -.
DR HOGENOM; CLU_114645_2_1_1; -.
DR InParanoid; Q969Q0; -.
DR OMA; DILVMTN; -.
DR OrthoDB; 1392093at2759; -.
DR PhylomeDB; Q969Q0; -.
DR TreeFam; TF300213; -.
DR PathwayCommons; Q969Q0; -.
DR Reactome; R-HSA-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-HSA-156902; Peptide chain elongation.
DR Reactome; R-HSA-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-HSA-192823; Viral mRNA Translation.
DR Reactome; R-HSA-2408557; Selenocysteine synthesis.
DR Reactome; R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-HSA-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-HSA-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-HSA-72764; Eukaryotic Translation Termination.
DR Reactome; R-HSA-9010553; Regulation of expression of SLITs and ROBOs.
DR Reactome; R-HSA-9633012; Response of EIF2AK4 (GCN2) to amino acid deficiency.
DR Reactome; R-HSA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-HSA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR SignaLink; Q969Q0; -.
DR SIGNOR; Q969Q0; -.
DR BioGRID-ORCS; 6166; 419 hits in 1011 CRISPR screens.
DR ChiTaRS; RPL36AL; human.
DR GenomeRNAi; 6166; -.
DR Pharos; Q969Q0; Tbio.
DR PRO; PR:Q969Q0; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q969Q0; protein.
DR Bgee; ENSG00000165502; Expressed in germinal epithelium of ovary and 203 other tissues.
DR Genevisible; Q969Q0; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:BHF-UCL.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR InterPro; IPR000552; Ribosomal_L44e.
DR InterPro; IPR011332; Ribosomal_zn-bd.
DR PANTHER; PTHR10369; PTHR10369; 1.
DR Pfam; PF00935; Ribosomal_L44; 1.
DR SUPFAM; SSF57829; SSF57829; 1.
DR PROSITE; PS01172; RIBOSOMAL_L44E; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Direct protein sequencing; Methylation; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..106
FT /note="60S ribosomal protein L36a-like"
FT /id="PRO_0000149118"
FT REGION 26..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 53
FT /note="N6-methyllysine"
FT /evidence="ECO:0000269|Ref.6"
FT VARIANT 66
FT /note="I -> V (in dbSNP:rs3088024)"
FT /id="VAR_051809"
SQ SEQUENCE 106 AA; 12469 MW; 9C0E08264A578D31 CRC64;
MVNVPKTRRT FCKKCGKHQP HKVTQYKKGK DSLYAQGRRR YDRKQSGYGG QTKPIFRKKA
KTTKKIVLRL ECVEPNCRSK RMLAIKRCKH FELGGDKKRK GQVIQF
