RL36_DROME
ID RL36_DROME Reviewed; 115 AA.
AC P49630; A2RVC6; Q0KHX6; Q9W5E5;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=60S ribosomal protein L36;
DE AltName: Full=Protein minute(1)1B;
GN Name=RpL36; Synonyms=M(1)1B; ORFNames=CG7622;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Oregon-R;
RA Steinhauer W.R.;
RT "Sequence of the M(1)1B gene of Drosophila melanogaster.";
RL Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oregon-R;
RX PubMed=10731137; DOI=10.1126/science.287.5461.2220;
RA Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G.,
RA Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Borkova D., Minana B., Kafatos F.C.,
RA Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L.,
RA Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P.,
RA Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H.,
RA Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
RA McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
RA Glover D.M.;
RT "From sequence to chromosome: the tip of the X chromosome of D.
RT melanogaster.";
RL Science 287:2220-2222(2000).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Testis;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP STRUCTURE BY ELECTRON MICROSCOPY (6.0 ANGSTROMS) OF THE 80S RIBOSOME.
RX PubMed=23636399; DOI=10.1038/nature12104;
RA Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA Wilson D.N., Beckmann R.;
RT "Structures of the human and Drosophila 80S ribosome.";
RL Nature 497:80-85(2013).
CC -!- FUNCTION: Component of the large ribosomal subunit.
CC {ECO:0000269|PubMed:23636399}.
CC -!- SUBUNIT: Component of the large ribosomal subunit.
CC {ECO:0000269|PubMed:23636399}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q9Y3U8}. Cytoplasm
CC {ECO:0000305|PubMed:23636399}. Note=Detected on cytosolic polysomes.
CC {ECO:0000250|UniProtKB:Q9Y3U8}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL36 family.
CC {ECO:0000305}.
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DR EMBL; U20543; AAA63151.1; -; Genomic_DNA.
DR EMBL; AE014298; AAN09019.1; -; Genomic_DNA.
DR EMBL; AE014298; AAN09020.1; -; Genomic_DNA.
DR EMBL; AE014298; AAN09021.1; -; Genomic_DNA.
DR EMBL; AL031581; CAA20892.1; -; Genomic_DNA.
DR EMBL; AY070831; AAL48453.1; -; mRNA.
DR EMBL; BT029917; ABM92791.1; -; mRNA.
DR PIR; T13383; T13383.
DR RefSeq; NP_001284750.1; NM_001297821.1.
DR RefSeq; NP_476629.1; NM_057281.4.
DR RefSeq; NP_726686.1; NM_166853.2.
DR RefSeq; NP_726687.1; NM_166854.2.
DR RefSeq; NP_726688.1; NM_166855.2.
DR PDB; 4V6W; EM; 6.00 A; Ci=1-115.
DR PDB; 6XU6; EM; 3.50 A; Ci=1-113.
DR PDB; 6XU7; EM; 4.90 A; Ci=1-113.
DR PDB; 6XU8; EM; 3.00 A; Ci=1-113.
DR PDBsum; 4V6W; -.
DR PDBsum; 6XU6; -.
DR PDBsum; 6XU7; -.
DR PDBsum; 6XU8; -.
DR AlphaFoldDB; P49630; -.
DR SMR; P49630; -.
DR BioGRID; 57577; 101.
DR DIP; DIP-21779N; -.
DR IntAct; P49630; 10.
DR STRING; 7227.FBpp0070150; -.
DR PaxDb; P49630; -.
DR PRIDE; P49630; -.
DR DNASU; 31009; -.
DR EnsemblMetazoa; FBtr0070155; FBpp0070150; FBgn0002579.
DR EnsemblMetazoa; FBtr0070156; FBpp0070151; FBgn0002579.
DR EnsemblMetazoa; FBtr0070157; FBpp0070152; FBgn0002579.
DR EnsemblMetazoa; FBtr0070158; FBpp0070153; FBgn0002579.
DR EnsemblMetazoa; FBtr0345321; FBpp0311481; FBgn0002579.
DR GeneID; 31009; -.
DR KEGG; dme:Dmel_CG7622; -.
DR CTD; 25873; -.
DR FlyBase; FBgn0002579; RpL36.
DR VEuPathDB; VectorBase:FBgn0002579; -.
DR eggNOG; KOG3452; Eukaryota.
DR HOGENOM; CLU_140672_0_0_1; -.
DR InParanoid; P49630; -.
DR OMA; KGRQTKH; -.
DR OrthoDB; 1477459at2759; -.
DR PhylomeDB; P49630; -.
DR Reactome; R-DME-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DME-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-DME-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DME-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-DME-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-DME-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR SignaLink; P49630; -.
DR BioGRID-ORCS; 31009; 0 hits in 1 CRISPR screen.
DR ChiTaRS; RpL36; fly.
DR GenomeRNAi; 31009; -.
DR PRO; PR:P49630; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0002579; Expressed in eye disc (Drosophila) and 26 other tissues.
DR ExpressionAtlas; P49630; baseline and differential.
DR Genevisible; P49630; DM.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0022626; C:cytosolic ribosome; IDA:FlyBase.
DR GO; GO:0005730; C:nucleolus; IDA:FlyBase.
DR GO; GO:0003735; F:structural constituent of ribosome; IDA:FlyBase.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR Gene3D; 1.10.10.1760; -; 1.
DR InterPro; IPR038097; L36e_sf.
DR InterPro; IPR000509; Ribosomal_L36e.
DR PANTHER; PTHR10114; PTHR10114; 1.
DR Pfam; PF01158; Ribosomal_L36e; 1.
DR PROSITE; PS01190; RIBOSOMAL_L36E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT CHAIN 1..115
FT /note="60S ribosomal protein L36"
FT /id="PRO_0000195011"
SQ SEQUENCE 115 AA; 13502 MW; C9B657B7A6442545 CRC64;
MAVRYELAIG LNKGHKTSKI RNVKYTGDKK VKGLRGSRLK NIQTRHTKFM RDLVREVVGH
APYEKRTMEL LKVSKDKRAL KFLKRRLGTH IRAKRKREEL SNILTQLRKA QTHAK
