RL37A_PYRFU
ID RL37A_PYRFU Reviewed; 83 AA.
AC Q8TZI4;
DT 30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=50S ribosomal protein L37Ae {ECO:0000255|HAMAP-Rule:MF_00327};
DE AltName: Full=Large ribosomal subunit protein eL43;
DE AltName: Full=Ribosomal protein L43e {ECO:0000255|HAMAP-Rule:MF_00327};
GN Name=rpl37ae {ECO:0000255|HAMAP-Rule:MF_00327}; OrderedLocusNames=PF2008;
OS Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=186497;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA DiRuggiero J., Robb F.T.;
RT "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT horikoshii inferred from complete genomic sequences.";
RL Genetics 152:1299-1305(1999).
RN [2] {ECO:0007744|PDB:4V6U}
RP STRUCTURE BY ELECTRON MICROSCOPY (6.60 ANGSTROMS) IN THE 70S RIBOSOME, AND
RP SUBUNIT.
RX PubMed=23222135; DOI=10.1093/nar/gks1259;
RA Armache J.P., Anger A.M., Marquez V., Franckenberg S., Frohlich T.,
RA Villa E., Berninghausen O., Thomm M., Arnold G.J., Beckmann R.,
RA Wilson D.N.;
RT "Promiscuous behaviour of archaeal ribosomal proteins: implications for
RT eukaryotic ribosome evolution.";
RL Nucleic Acids Res. 41:1284-1293(2013).
CC -!- FUNCTION: Binds to the 23S rRNA. {ECO:0000255|HAMAP-Rule:MF_00327}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00327};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_00327};
CC -!- SUBUNIT: Part of the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC Rule:MF_00327, ECO:0000269|PubMed:23222135}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL43 family.
CC Putative zinc-binding subfamily. {ECO:0000255|HAMAP-Rule:MF_00327}.
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DR EMBL; AE009950; AAL82132.1; -; Genomic_DNA.
DR RefSeq; WP_011013153.1; NZ_CP023154.1.
DR PDB; 4V6U; EM; 6.60 A; Bi=1-83.
DR PDBsum; 4V6U; -.
DR AlphaFoldDB; Q8TZI4; -.
DR SMR; Q8TZI4; -.
DR STRING; 186497.PF2008; -.
DR PRIDE; Q8TZI4; -.
DR EnsemblBacteria; AAL82132; AAL82132; PF2008.
DR GeneID; 41713834; -.
DR KEGG; pfu:PF2008; -.
DR PATRIC; fig|186497.12.peg.2085; -.
DR eggNOG; arCOG04208; Archaea.
DR HOGENOM; CLU_141199_2_0_2; -.
DR OMA; ISTGIWQ; -.
DR OrthoDB; 122290at2157; -.
DR PhylomeDB; Q8TZI4; -.
DR Proteomes; UP000001013; Chromosome.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR Gene3D; 2.20.25.30; -; 1.
DR HAMAP; MF_00327; Ribosomal_L37Ae; 1.
DR InterPro; IPR002674; Ribosomal_L37ae.
DR InterPro; IPR011331; Ribosomal_L37ae/L37e.
DR InterPro; IPR011332; Ribosomal_zn-bd.
DR Pfam; PF01780; Ribosomal_L37ae; 1.
DR SUPFAM; SSF57829; SSF57829; 1.
DR TIGRFAMs; TIGR00280; eL43_euk_arch; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Metal-binding; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; RNA-binding; rRNA-binding; Zinc; Zinc-finger.
FT CHAIN 1..83
FT /note="50S ribosomal protein L37Ae"
FT /id="PRO_0000139851"
FT ZN_FING 38..59
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00327"
FT BINDING 38
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00327"
FT BINDING 41
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00327"
FT BINDING 56
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00327"
FT BINDING 59
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00327"
SQ SEQUENCE 83 AA; 8937 MW; 2541D6C7BF10B526 CRC64;
MSGTKKVGSA GRFGARYGLK IRRRVAAVEA KMRQKHTCPV CGRKAVKRIS TGIWQCQKCG
ATFAGGAYLP VTPAGKAVRR ITE
