RL38_RAT
ID RL38_RAT Reviewed; 70 AA.
AC P63174; P23411; Q3T1G5;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=60S ribosomal protein L38;
GN Name=Rpl38;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-33.
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=1840484; DOI=10.1016/0006-291x(91)91600-h;
RA Kuwano Y., Olvera J., Wool I.G.;
RT "The primary structure of rat ribosomal protein L38.";
RL Biochem. Biophys. Res. Commun. 175:551-555(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. {ECO:0000250|UniProtKB:P63173}.
CC -!- SUBUNIT: Component of the large ribosomal subunit.
CC {ECO:0000250|UniProtKB:P63173}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P63173}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL38 family.
CC {ECO:0000305}.
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DR EMBL; X57007; CAA40328.1; -; mRNA.
DR EMBL; BC101933; AAI01934.1; -; mRNA.
DR PIR; S15658; R5RT38.
DR RefSeq; NP_001071060.1; NM_001077592.1.
DR RefSeq; XP_001063134.1; XM_001063134.5.
DR RefSeq; XP_001065954.1; XM_001065954.6.
DR RefSeq; XP_001074532.1; XM_001074532.5.
DR RefSeq; XP_002726074.1; XM_002726028.5.
DR RefSeq; XP_008766615.1; XM_008768393.1.
DR AlphaFoldDB; P63174; -.
DR SMR; P63174; -.
DR BioGRID; 604106; 1.
DR IntAct; P63174; 3.
DR STRING; 10116.ENSRNOP00000023368; -.
DR iPTMnet; P63174; -.
DR PhosphoSitePlus; P63174; -.
DR jPOST; P63174; -.
DR PaxDb; P63174; -.
DR PRIDE; P63174; -.
DR Ensembl; ENSRNOT00000023369; ENSRNOP00000023368; ENSRNOG00000049047.
DR Ensembl; ENSRNOT00000042661; ENSRNOP00000042022; ENSRNOG00000030747.
DR Ensembl; ENSRNOT00000044141; ENSRNOP00000042288; ENSRNOG00000048701.
DR Ensembl; ENSRNOT00000050489; ENSRNOP00000050353; ENSRNOG00000033686.
DR Ensembl; ENSRNOT00000095224; ENSRNOP00000088903; ENSRNOG00000066047.
DR GeneID; 685963; -.
DR GeneID; 689284; -.
DR GeneID; 690468; -.
DR KEGG; rno:685963; -.
DR KEGG; rno:689284; -.
DR KEGG; rno:690468; -.
DR CTD; 6169; -.
DR RGD; 1305573; Rpl38.
DR VEuPathDB; HostDB:ENSRNOG00000029377; -.
DR eggNOG; KOG3499; Eukaryota.
DR GeneTree; ENSGT00390000003718; -.
DR HOGENOM; CLU_152057_2_0_1; -.
DR InParanoid; P63174; -.
DR OMA; RCHRHLY; -.
DR OrthoDB; 1619070at2759; -.
DR PhylomeDB; P63174; -.
DR TreeFam; TF300215; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P63174; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Proteomes; UP000002494; Chromosome 14.
DR Proteomes; UP000002494; Chromosome 16.
DR Proteomes; UP000002494; Chromosome 2.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000030747; Expressed in thymus and 19 other tissues.
DR Genevisible; P63174; RN.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:RGD.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0033291; C:eukaryotic 80S initiation complex; ISO:RGD.
DR GO; GO:0042788; C:polysomal ribosome; ISO:RGD.
DR GO; GO:0014069; C:postsynaptic density; ISO:RGD.
DR GO; GO:0045202; C:synapse; ISO:RGD.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:0034463; P:90S preribosome assembly; ISO:RGD.
DR GO; GO:0048318; P:axial mesoderm development; ISO:RGD.
DR GO; GO:0002181; P:cytoplasmic translation; ISO:RGD.
DR GO; GO:0042474; P:middle ear morphogenesis; ISO:RGD.
DR GO; GO:0001503; P:ossification; ISO:RGD.
DR GO; GO:0006417; P:regulation of translation; ISO:RGD.
DR GO; GO:0022618; P:ribonucleoprotein complex assembly; IBA:GO_Central.
DR GO; GO:0007605; P:sensory perception of sound; ISO:RGD.
DR GO; GO:0001501; P:skeletal system development; ISO:RGD.
DR Gene3D; 3.30.720.90; -; 1.
DR InterPro; IPR002675; Ribosomal_L38e.
DR InterPro; IPR038464; Ribosomal_L38e_sf.
DR PANTHER; PTHR10965; PTHR10965; 1.
DR Pfam; PF01781; Ribosomal_L38e; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Direct protein sequencing; Isopeptide bond;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:1840484"
FT CHAIN 2..70
FT /note="60S ribosomal protein L38"
FT /id="PRO_0000215437"
FT MOD_RES 9
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P63173"
FT MOD_RES 67
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P63173"
FT CROSSLNK 4
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P63173"
FT CROSSLNK 9
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2); alternate"
FT /evidence="ECO:0000250|UniProtKB:P63173"
SQ SEQUENCE 70 AA; 8218 MW; FDD9A107BC98DBBA CRC64;
MPRKIEEIKD FLLTARRKDA KSVKIKKNKD NVKFKVRCSR YLYTLVITDK EKAEKLKQSL
PPGLAVKELK
