RL39L_HUMAN
ID RL39L_HUMAN Reviewed; 51 AA.
AC Q96EH5; Q8IUD0;
DT 28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=60S ribosomal protein L39-like;
DE AltName: Full=60S ribosomal protein L39-2;
DE AltName: Full=Large ribosomal subunit protein eL39-like;
GN Name=RPL39L; Synonyms=RPL39L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Bhat K.S.;
RT "Expressed sequence tags from a human cell line.";
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12359333; DOI=10.1016/s0167-4781(02)00445-1;
RA Nadano D., Notsu T., Matsuda T., Sato T.-A.;
RT "A human gene encoding a protein homologous to ribosomal protein L39 is
RT normally expressed in the testis and derepressed in multiple cancer
RT cells.";
RL Biochim. Biophys. Acta 1577:430-436(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=12490704; DOI=10.1093/nar/gkf696;
RA Uechi T., Maeda N., Tanaka T., Kenmochi N.;
RT "Functional second genes generated by retrotransposition of the X-linked
RT ribosomal protein genes.";
RL Nucleic Acids Res. 30:5369-5375(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96EH5; O95273: CCNDBP1; NbExp=4; IntAct=EBI-6658607, EBI-748961;
CC -!- TISSUE SPECIFICITY: Testis specific.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL39 family.
CC {ECO:0000305}.
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DR EMBL; L05096; AAC15859.1; -; mRNA.
DR EMBL; AF548529; AAN52397.1; -; mRNA.
DR EMBL; AB063607; BAC19834.1; -; Genomic_DNA.
DR EMBL; AB063610; BAC19837.1; -; mRNA.
DR EMBL; BC012328; AAH12328.1; -; mRNA.
DR CCDS; CCDS3286.1; -.
DR RefSeq; NP_443201.1; NM_052969.2.
DR AlphaFoldDB; Q96EH5; -.
DR SMR; Q96EH5; -.
DR BioGRID; 125530; 3.
DR IntAct; Q96EH5; 3.
DR STRING; 9606.ENSP00000296277; -.
DR iPTMnet; Q96EH5; -.
DR PhosphoSitePlus; Q96EH5; -.
DR BioMuta; RPL39L; -.
DR DMDM; 29427944; -.
DR MassIVE; Q96EH5; -.
DR PaxDb; Q96EH5; -.
DR PeptideAtlas; Q96EH5; -.
DR PRIDE; Q96EH5; -.
DR TopDownProteomics; Q96EH5; -.
DR Antibodypedia; 33862; 104 antibodies from 25 providers.
DR DNASU; 116832; -.
DR Ensembl; ENST00000296277.9; ENSP00000296277.4; ENSG00000163923.10.
DR Ensembl; ENST00000433055.1; ENSP00000389356.1; ENSG00000163923.10.
DR Ensembl; ENST00000455270.5; ENSP00000397240.1; ENSG00000163923.10.
DR GeneID; 116832; -.
DR KEGG; hsa:116832; -.
DR MANE-Select; ENST00000296277.9; ENSP00000296277.4; NM_052969.3; NP_443201.1.
DR UCSC; uc003fre.2; human.
DR CTD; 116832; -.
DR DisGeNET; 116832; -.
DR GeneCards; RPL39L; -.
DR HGNC; HGNC:17094; RPL39L.
DR HPA; ENSG00000163923; Tissue enriched (testis).
DR MIM; 607547; gene.
DR neXtProt; NX_Q96EH5; -.
DR OpenTargets; ENSG00000163923; -.
DR PharmGKB; PA34744; -.
DR VEuPathDB; HostDB:ENSG00000163923; -.
DR eggNOG; KOG0002; Eukaryota.
DR GeneTree; ENSGT00940000165055; -.
DR HOGENOM; CLU_181948_3_0_1; -.
DR InParanoid; Q96EH5; -.
DR OMA; RIFAQPS; -.
DR OrthoDB; 1618745at2759; -.
DR PhylomeDB; Q96EH5; -.
DR TreeFam; TF300223; -.
DR PathwayCommons; Q96EH5; -.
DR Reactome; R-HSA-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-HSA-156902; Peptide chain elongation.
DR Reactome; R-HSA-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-HSA-192823; Viral mRNA Translation.
DR Reactome; R-HSA-2408557; Selenocysteine synthesis.
DR Reactome; R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-HSA-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-HSA-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-HSA-72764; Eukaryotic Translation Termination.
DR Reactome; R-HSA-9010553; Regulation of expression of SLITs and ROBOs.
DR Reactome; R-HSA-9633012; Response of EIF2AK4 (GCN2) to amino acid deficiency.
DR Reactome; R-HSA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-HSA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR SignaLink; Q96EH5; -.
DR SIGNOR; Q96EH5; -.
DR BioGRID-ORCS; 116832; 47 hits in 994 CRISPR screens.
DR ChiTaRS; RPL39L; human.
DR GenomeRNAi; 116832; -.
DR Pharos; Q96EH5; Tbio.
DR PRO; PR:Q96EH5; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q96EH5; protein.
DR Bgee; ENSG00000163923; Expressed in left testis and 123 other tissues.
DR Genevisible; Q96EH5; HS.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0007283; P:spermatogenesis; IEP:UniProtKB.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 1.10.1620.10; -; 1.
DR HAMAP; MF_00629; Ribosomal_L39e; 1.
DR InterPro; IPR000077; Ribosomal_L39.
DR InterPro; IPR020083; Ribosomal_L39_CS.
DR InterPro; IPR023626; Ribosomal_L39e_dom_sf.
DR Pfam; PF00832; Ribosomal_L39; 1.
DR SUPFAM; SSF48662; SSF48662; 1.
DR PROSITE; PS00051; RIBOSOMAL_L39E; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..51
FT /note="60S ribosomal protein L39-like"
FT /id="PRO_0000127027"
SQ SEQUENCE 51 AA; 6293 MW; 7010DF584034CB2E CRC64;
MSSHKTFTIK RFLAKKQKQN RPIPQWIQMK PGSKIRYNSK RRHWRRTKLG L
