RL39_RAT
ID RL39_RAT Reviewed; 51 AA.
AC P62893; P02404; P39025; Q9BYF2;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=60S ribosomal protein L39;
GN Name=Rpl39;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=7654221; DOI=10.1006/bbrc.1995.2233;
RA Chan Y.-L., Olvera J., Wool I.G.;
RT "The primary structures of rat ribosomal proteins: the characterization of
RT the cDNAs for S21 and L39, corrections in the sequences of L7 and L18a, and
RT the identification of L33.";
RL Biochem. Biophys. Res. Commun. 213:1042-1050(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 2-51.
RC TISSUE=Liver;
RX PubMed=6706949; DOI=10.1016/s0021-9258(17)43687-8;
RA Lin A., McNally J., Wool I.G.;
RT "The primary structure of rat liver ribosomal protein L39.";
RL J. Biol. Chem. 259:487-490(1984).
CC -!- FUNCTION: RNA-binding component of the large ribosomal subunit. The
CC ribosome is a large ribonucleoprotein complex responsible for the
CC synthesis of proteins in the cell. {ECO:0000250|UniProtKB:P62891}.
CC -!- SUBUNIT: Component of the large ribosomal subunit (By similarity).
CC Interacts with IMPACT (By similarity). {ECO:0000250|UniProtKB:P62891,
CC ECO:0000250|UniProtKB:P62892}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62891}.
CC -!- MISCELLANEOUS: This protein is the smallest and one of the most basic
CC of the proteins in liver ribosomes. {ECO:0000269|PubMed:6706949}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL39 family.
CC {ECO:0000305}.
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DR EMBL; X82551; CAA57900.1; -; mRNA.
DR EMBL; BC058489; AAH58489.1; -; mRNA.
DR PIR; JC4229; R6RT39.
DR RefSeq; NP_037007.1; NM_012875.2.
DR RefSeq; XP_008756620.1; XM_008758398.2.
DR RefSeq; XP_008763422.1; XM_008765200.2.
DR RefSeq; XP_008763542.2; XM_008765320.2.
DR RefSeq; XP_008766241.1; XM_008768019.2.
DR RefSeq; XP_008768328.1; XM_008770106.2.
DR RefSeq; XP_008768835.1; XM_008770613.2.
DR RefSeq; XP_008770213.1; XM_008771991.2.
DR RefSeq; XP_008771160.1; XM_008772938.2.
DR RefSeq; XP_008771430.1; XM_008773208.2.
DR RefSeq; XP_008772314.1; XM_008774092.1.
DR RefSeq; XP_008773161.1; XM_008774939.2.
DR AlphaFoldDB; P62893; -.
DR SMR; P62893; -.
DR IntAct; P62893; 5.
DR STRING; 10116.ENSRNOP00000041329; -.
DR jPOST; P62893; -.
DR PaxDb; P62893; -.
DR PRIDE; P62893; -.
DR Ensembl; ENSRNOT00000043244; ENSRNOP00000049713; ENSRNOG00000034237.
DR Ensembl; ENSRNOT00000046536; ENSRNOP00000049665; ENSRNOG00000048073.
DR Ensembl; ENSRNOT00000050345; ENSRNOP00000044553; ENSRNOG00000029267.
DR Ensembl; ENSRNOT00000051137; ENSRNOP00000041329; ENSRNOG00000050393.
DR Ensembl; ENSRNOT00000059010; ENSRNOP00000055790; ENSRNOG00000067660.
DR GeneID; 103690821; -.
DR GeneID; 103692785; -.
DR GeneID; 103692831; -.
DR GeneID; 103693375; -.
DR GeneID; 103694169; -.
DR GeneID; 103694404; -.
DR GeneID; 25347; -.
DR KEGG; rno:103690821; -.
DR KEGG; rno:103692785; -.
DR KEGG; rno:103692831; -.
DR KEGG; rno:103693375; -.
DR KEGG; rno:103694169; -.
DR KEGG; rno:103694404; -.
DR KEGG; rno:25347; -.
DR UCSC; RGD:3593; rat.
DR CTD; 6170; -.
DR RGD; 3593; Rpl39.
DR VEuPathDB; HostDB:ENSRNOG00000043348; -.
DR VEuPathDB; HostDB:ENSRNOG00000067028; -.
DR eggNOG; KOG0002; Eukaryota.
DR GeneTree; ENSGT00390000014814; -.
DR HOGENOM; CLU_181948_3_0_1; -.
DR InParanoid; P62893; -.
DR OMA; MKRRHWR; -.
DR OrthoDB; 1618745at2759; -.
DR PhylomeDB; P62893; -.
DR TreeFam; TF300223; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P62893; -.
DR Proteomes; UP000002494; Chromosome 15.
DR Proteomes; UP000002494; Chromosome 18.
DR Proteomes; UP000002494; Chromosome 20.
DR Proteomes; UP000002494; Chromosome 7.
DR Proteomes; UP000002494; Chromosome X.
DR Bgee; ENSRNOG00000029267; Expressed in spleen and 1 other tissue.
DR ExpressionAtlas; P62893; baseline and differential.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:RGD.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0042788; C:polysomal ribosome; ISO:RGD.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:0019731; P:antibacterial humoral response; ISO:RGD.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:RGD.
DR GO; GO:0002181; P:cytoplasmic translation; ISO:RGD.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:RGD.
DR GO; GO:0002227; P:innate immune response in mucosa; ISO:RGD.
DR Gene3D; 1.10.1620.10; -; 1.
DR HAMAP; MF_00629; Ribosomal_L39e; 1.
DR InterPro; IPR000077; Ribosomal_L39.
DR InterPro; IPR020083; Ribosomal_L39_CS.
DR InterPro; IPR023626; Ribosomal_L39e_dom_sf.
DR Pfam; PF00832; Ribosomal_L39; 1.
DR SUPFAM; SSF48662; SSF48662; 1.
DR PROSITE; PS00051; RIBOSOMAL_L39E; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Direct protein sequencing; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:6706949"
FT CHAIN 2..51
FT /note="60S ribosomal protein L39"
FT /id="PRO_0000127026"
SQ SEQUENCE 51 AA; 6407 MW; 2023CA8590C7752C CRC64;
MSSHKTFRIK RFLAKKQKQN RPIPQWIRMK TGNKIRYNSK RRHWRRTKLG L
