RL3_ASPFU
ID RL3_ASPFU Reviewed; 392 AA.
AC Q8NKF4; Q4X0Y6;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=60S ribosomal protein L3;
DE AltName: Allergen=Asp f 23;
GN Name=rpl3; ORFNames=AFUA_2G11850;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAM43909.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RX PubMed=12974759; DOI=10.1046/j.1365-2249.2003.02257.x;
RA Saxena S., Madan T., Muralidhar K., Sarma P.U.;
RT "cDNA cloning, expression and characterization of an allergenic L3
RT ribosomal protein of Aspergillus fumigatus.";
RL Clin. Exp. Immunol. 134:86-91(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: The L3 protein is a component of the large subunit of
CC cytoplasmic ribosomes. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE and IgG.
CC {ECO:0000269|PubMed:12974759}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL3 family.
CC {ECO:0000255}.
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DR EMBL; AF464911; AAM43909.1; -; mRNA.
DR EMBL; AAHF01000001; EAL93479.1; -; Genomic_DNA.
DR RefSeq; XP_755517.1; XM_750424.1.
DR AlphaFoldDB; Q8NKF4; -.
DR SMR; Q8NKF4; -.
DR STRING; 746128.CADAFUBP00002697; -.
DR Allergome; 1183; Asp f 23.
DR Allergome; 3117; Asp f 23.0101.
DR PRIDE; Q8NKF4; -.
DR EnsemblFungi; EAL93479; EAL93479; AFUA_2G11850.
DR GeneID; 3513239; -.
DR KEGG; afm:AFUA_2G11850; -.
DR VEuPathDB; FungiDB:Afu2g11850; -.
DR eggNOG; KOG0746; Eukaryota.
DR HOGENOM; CLU_033361_2_1_1; -.
DR InParanoid; Q8NKF4; -.
DR OMA; HQRTEYN; -.
DR OrthoDB; 793191at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR Gene3D; 4.10.960.10; -; 1.
DR InterPro; IPR045077; L3_arc_euk.
DR InterPro; IPR000597; Ribosomal_L3.
DR InterPro; IPR019926; Ribosomal_L3_CS.
DR InterPro; IPR044892; Ribosomal_L3_dom_3_arc_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR PANTHER; PTHR11363; PTHR11363; 1.
DR Pfam; PF00297; Ribosomal_L3; 1.
DR SUPFAM; SSF50447; SSF50447; 1.
DR PROSITE; PS00474; RIBOSOMAL_L3; 1.
PE 1: Evidence at protein level;
KW Allergen; Cytoplasm; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT CHAIN 1..392
FT /note="60S ribosomal protein L3"
FT /id="PRO_0000077244"
FT CONFLICT 35
FT /note="D -> Y (in Ref. 1; AAM43909)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 392 AA; 44445 MW; 0A2D7C976D1023F5 CRC64;
MSHRKYEAPR HGSLAFLPRK RAARHRGKVK SFPKDDPKKP VHLTASMGYK AGMTTVVRDL
DRPGAKMHKK EIVEAVTIIE TPPLVAVGVV GYIETPRGLR SLTTVWAEHL SDEVKRRFYK
NWYKSKKKAF TKYAKKHAEE NGASITRELE RIKKYCTVVR VLAHTQIRKT PLKQKKAHLM
EIQVNGGSVA DKVDFARNLF EKPIEIDSIF EKDEMIDVIA VTKGHGFQGV TSRWGTKKLP
RKTHKGLRKV ACIGAWHPSH VQWTVARAGQ MGYHHRTSCN HKVFRIGKGS DEGNASTDFD
ISKKQITPMG GFVRYGEVKN DYIMVKGSVP GVKKRVMTLR KTLYPQTSRR ATEKVELKWI
DTSSKFGHGA FQTPEEKRAF MGTLKKDLVT SA