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RL3_ASPFU
ID   RL3_ASPFU               Reviewed;         392 AA.
AC   Q8NKF4; Q4X0Y6;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 2.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=60S ribosomal protein L3;
DE   AltName: Allergen=Asp f 23;
GN   Name=rpl3; ORFNames=AFUA_2G11850;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAM43909.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RX   PubMed=12974759; DOI=10.1046/j.1365-2249.2003.02257.x;
RA   Saxena S., Madan T., Muralidhar K., Sarma P.U.;
RT   "cDNA cloning, expression and characterization of an allergenic L3
RT   ribosomal protein of Aspergillus fumigatus.";
RL   Clin. Exp. Immunol. 134:86-91(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: The L3 protein is a component of the large subunit of
CC       cytoplasmic ribosomes. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE and IgG.
CC       {ECO:0000269|PubMed:12974759}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL3 family.
CC       {ECO:0000255}.
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DR   EMBL; AF464911; AAM43909.1; -; mRNA.
DR   EMBL; AAHF01000001; EAL93479.1; -; Genomic_DNA.
DR   RefSeq; XP_755517.1; XM_750424.1.
DR   AlphaFoldDB; Q8NKF4; -.
DR   SMR; Q8NKF4; -.
DR   STRING; 746128.CADAFUBP00002697; -.
DR   Allergome; 1183; Asp f 23.
DR   Allergome; 3117; Asp f 23.0101.
DR   PRIDE; Q8NKF4; -.
DR   EnsemblFungi; EAL93479; EAL93479; AFUA_2G11850.
DR   GeneID; 3513239; -.
DR   KEGG; afm:AFUA_2G11850; -.
DR   VEuPathDB; FungiDB:Afu2g11850; -.
DR   eggNOG; KOG0746; Eukaryota.
DR   HOGENOM; CLU_033361_2_1_1; -.
DR   InParanoid; Q8NKF4; -.
DR   OMA; HQRTEYN; -.
DR   OrthoDB; 793191at2759; -.
DR   Proteomes; UP000002530; Chromosome 2.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; IBA:GO_Central.
DR   Gene3D; 4.10.960.10; -; 1.
DR   InterPro; IPR045077; L3_arc_euk.
DR   InterPro; IPR000597; Ribosomal_L3.
DR   InterPro; IPR019926; Ribosomal_L3_CS.
DR   InterPro; IPR044892; Ribosomal_L3_dom_3_arc_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   PANTHER; PTHR11363; PTHR11363; 1.
DR   Pfam; PF00297; Ribosomal_L3; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   PROSITE; PS00474; RIBOSOMAL_L3; 1.
PE   1: Evidence at protein level;
KW   Allergen; Cytoplasm; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein.
FT   CHAIN           1..392
FT                   /note="60S ribosomal protein L3"
FT                   /id="PRO_0000077244"
FT   CONFLICT        35
FT                   /note="D -> Y (in Ref. 1; AAM43909)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   392 AA;  44445 MW;  0A2D7C976D1023F5 CRC64;
     MSHRKYEAPR HGSLAFLPRK RAARHRGKVK SFPKDDPKKP VHLTASMGYK AGMTTVVRDL
     DRPGAKMHKK EIVEAVTIIE TPPLVAVGVV GYIETPRGLR SLTTVWAEHL SDEVKRRFYK
     NWYKSKKKAF TKYAKKHAEE NGASITRELE RIKKYCTVVR VLAHTQIRKT PLKQKKAHLM
     EIQVNGGSVA DKVDFARNLF EKPIEIDSIF EKDEMIDVIA VTKGHGFQGV TSRWGTKKLP
     RKTHKGLRKV ACIGAWHPSH VQWTVARAGQ MGYHHRTSCN HKVFRIGKGS DEGNASTDFD
     ISKKQITPMG GFVRYGEVKN DYIMVKGSVP GVKKRVMTLR KTLYPQTSRR ATEKVELKWI
     DTSSKFGHGA FQTPEEKRAF MGTLKKDLVT SA
 
 
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