ID   RL3_CAEEL               Reviewed;         401 AA.
AC   P50880;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=60S ribosomal protein L3;
GN   Name=rpl-3; ORFNames=F13B10.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=Bristol N2;
RX   PubMed=8988366; DOI=10.3109/10425179609020877;
RA   Zhu X., Joh K., Hori K.;
RT   "Nucleotide sequence of ribosomal protein L3 cDNA and the exon-intron
RT   structure of L3 gene in the nematode, Caenorhabditis elegans.";
RL   DNA Seq. 6:299-302(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: The L3 protein is a component of the large subunit of
CC       cytoplasmic ribosomes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL3 family.
CC       {ECO:0000305}.
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DR   EMBL; Z69337; CAA93269.1; -; Genomic_DNA.
DR   EMBL; Z69336; CAA93268.1; -; mRNA.
DR   EMBL; Z49936; CAA90183.1; -; Genomic_DNA.
DR   EMBL; Z66495; CAA90183.1; JOINED; Genomic_DNA.
DR   PIR; T19771; T19771.
DR   RefSeq; NP_001021254.1; NM_001026083.4.
DR   AlphaFoldDB; P50880; -.
DR   SMR; P50880; -.
DR   BioGRID; 40739; 16.
DR   DIP; DIP-24912N; -.
DR   IntAct; P50880; 1.
DR   STRING; 6239.F13B10.2a.1; -.
DR   EPD; P50880; -.
DR   PaxDb; P50880; -.
DR   PeptideAtlas; P50880; -.
DR   EnsemblMetazoa; F13B10.2a.1; F13B10.2a.1; WBGene00004414.
DR   EnsemblMetazoa; F13B10.2a.2; F13B10.2a.2; WBGene00004414.
DR   GeneID; 175501; -.
DR   KEGG; cel:CELE_F13B10.2; -.
DR   UCSC; F13B10.2d.2; c. elegans.
DR   CTD; 175501; -.
DR   WormBase; F13B10.2a; CE05598; WBGene00004414; rpl-3.
DR   eggNOG; KOG0746; Eukaryota.
DR   GeneTree; ENSGT00390000017606; -.
DR   InParanoid; P50880; -.
DR   OMA; HQRTEYN; -.
DR   OrthoDB; 793191at2759; -.
DR   PhylomeDB; P50880; -.
DR   Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-CEL-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-CEL-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-CEL-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-CEL-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   SignaLink; P50880; -.
DR   PRO; PR:P50880; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00004414; Expressed in germ line (C elegans) and 4 other tissues.
DR   ExpressionAtlas; P50880; baseline and differential.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; IBA:GO_Central.
DR   Gene3D; 4.10.960.10; -; 1.
DR   InterPro; IPR045077; L3_arc_euk.
DR   InterPro; IPR000597; Ribosomal_L3.
DR   InterPro; IPR019926; Ribosomal_L3_CS.
DR   InterPro; IPR044892; Ribosomal_L3_dom_3_arc_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   PANTHER; PTHR11363; PTHR11363; 1.
DR   Pfam; PF00297; Ribosomal_L3; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   PROSITE; PS00474; RIBOSOMAL_L3; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT   CHAIN           1..401
FT                   /note="60S ribosomal protein L3"
FT                   /id="PRO_0000077235"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   401 AA;  45659 MW;  25F3DAE3714B0DFD CRC64;
     MSHRKFSAPR HGHMGFTPKK RSRTYRGRIK AFPKDDKSKP IHLTAFLGYK AGMTHIVRDV
     DKPGSKVNKK EVVEAVTIVE TPPMVIAGVT GYVDTPQGPR ALTTIWAEHL SEEARRRFYS
     NWAKSKKKAF TKYAKKWQDE DGKKLIEADF AKLKKYCSSI RVIAHTQMKI LRRRQKKAHL
     VEIQVNGGTI EQKVDWAREH LEKQVQVDTV FAQDEMIDTI GVTRGHGFKG VTSRWHTKKL
     PRKTHKGLRK VACIGAWHPS RVAFTVARAG QKGFHHRTII NNKIYRIGKS ALTEEGKNNG
     STEFDLTQKT ITPMGGFPRY GIVNQDYIML RGAVLGPKKR LITLRKSLIT QTKRVAHEKI
     NLKWIDTSSK TGHGRFQTTA EKRAFMGKLK RDFLAEAEAK A