RL3_DICDI
ID RL3_DICDI Reviewed; 398 AA.
AC P34113; Q54DX5;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=60S ribosomal protein L3;
GN Name=rpl3; ORFNames=DDB_G0291862;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7557399; DOI=10.1016/0378-1119(95)00361-9;
RA Steel L.F., Farnum P.D., Kunapoli P.;
RT "Sequence and developmental regulation of the gene that encodes the
RT Dictyostelium discoideum L3 ribosomal protein.";
RL Gene 162:123-128(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP PROTEIN SEQUENCE OF 146-155; 195-204 AND 357-365, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC STRAIN=AX2;
RA Bienvenut W.V., Ura S., Insall R.H.;
RL Submitted (JUL-2009) to UniProtKB.
CC -!- FUNCTION: The L3 protein is a component of the large subunit of
CC cytoplasmic ribosomes.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL3 family.
CC {ECO:0000305}.
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DR EMBL; L08391; AAA99508.1; -; Genomic_DNA.
DR EMBL; AAFI02000186; EAL61461.1; -; Genomic_DNA.
DR PIR; JC4254; JC4254.
DR RefSeq; XP_629921.1; XM_629919.1.
DR PDB; 5AN9; EM; 3.30 A; A=1-398.
DR PDB; 5ANB; EM; 4.10 A; A=1-398.
DR PDB; 5ANC; EM; 4.20 A; A=1-398.
DR PDB; 6QKL; EM; 3.30 A; A=1-398.
DR PDBsum; 5AN9; -.
DR PDBsum; 5ANB; -.
DR PDBsum; 5ANC; -.
DR PDBsum; 6QKL; -.
DR AlphaFoldDB; P34113; -.
DR SMR; P34113; -.
DR STRING; 44689.DDB0191094; -.
DR PaxDb; P34113; -.
DR EnsemblProtists; EAL61461; EAL61461; DDB_G0291862.
DR GeneID; 8628422; -.
DR KEGG; ddi:DDB_G0291862; -.
DR dictyBase; DDB_G0291862; rpl3.
DR eggNOG; KOG0746; Eukaryota.
DR HOGENOM; CLU_033361_2_1_1; -.
DR InParanoid; P34113; -.
DR OMA; HQRTEYN; -.
DR PhylomeDB; P34113; -.
DR Reactome; R-DDI-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DDI-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-DDI-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DDI-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-DDI-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-DDI-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P34113; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR Gene3D; 4.10.960.10; -; 1.
DR InterPro; IPR045077; L3_arc_euk.
DR InterPro; IPR000597; Ribosomal_L3.
DR InterPro; IPR019926; Ribosomal_L3_CS.
DR InterPro; IPR044892; Ribosomal_L3_dom_3_arc_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR PANTHER; PTHR11363; PTHR11363; 1.
DR Pfam; PF00297; Ribosomal_L3; 1.
DR SUPFAM; SSF50447; SSF50447; 1.
DR PROSITE; PS00474; RIBOSOMAL_L3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Direct protein sequencing; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..398
FT /note="60S ribosomal protein L3"
FT /id="PRO_0000077236"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 14..16
FT /evidence="ECO:0007829|PDB:5AN9"
FT TURN 39..41
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 45..59
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 63..66
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 71..80
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 84..93
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 101..106
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 112..115
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 119..121
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 142..156
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 157..159
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 162..166
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 170..175
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 181..185
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 191..200
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 202..206
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 208..211
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 214..216
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 218..223
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 232..236
FT /evidence="ECO:0007829|PDB:5AN9"
FT TURN 243..245
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 258..262
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 265..267
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 272..274
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 277..283
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 292..295
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 297..302
FT /evidence="ECO:0007829|PDB:5AN9"
FT TURN 316..321
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 329..334
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 343..348
FT /evidence="ECO:0007829|PDB:5AN9"
FT TURN 356..358
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 364..367
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 371..377
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 379..388
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 391..394
FT /evidence="ECO:0007829|PDB:5AN9"
SQ SEQUENCE 398 AA; 45060 MW; C569E2D1E1F44327 CRC64;
MSHRKFEAPR HGNLGFRPRK RAARHQGKVK SFPKDDRTQK VHLTAFMGYK AGMTHVVRDL
EKPGSKMHKK EIVEAVTIIE CPPMYIVGLV GYVETAQGLK TYKTVWAQHL SDNFRRRLYK
NWYKSKSKKA FTKYVKQYET EEGKKSIEAS LQAIKKRCSV VRVIAHTQVH KLKLTQKKAH
VLEIQVNGGS IVEKVNFAVA NFEKTVNVTG VFAENELIDV IGVTKGKGFN GVIKRWGVRK
LPRKTHKGLR KVACIGAWHP SRVSTTVPRA GQLGYHHRVE RNKKIYRIGQ AQPEDGKQIS
TGKTEFDLTE KTINPMGGFA HYGMVKHEFL MLKGCVAGPR KRALTLRKSI TTQTGRAALE
KITLKFIDTS SKFGHGLHQT AEDKTKYFGV KKSRSTKA
