ID   RL3_PYRFU               Reviewed;         365 AA.
AC   Q8TZZ8;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=50S ribosomal protein L3 {ECO:0000255|HAMAP-Rule:MF_01325};
DE   AltName: Full=Large ribosomal subunit protein uL3;
GN   Name=rpl3 {ECO:0000255|HAMAP-Rule:MF_01325}; OrderedLocusNames=PF1825;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
RN   [2] {ECO:0007744|PDB:4V6U}
RP   STRUCTURE BY ELECTRON MICROSCOPY (6.60 ANGSTROMS) IN THE 70S RIBOSOME, AND
RP   SUBUNIT.
RX   PubMed=23222135; DOI=10.1093/nar/gks1259;
RA   Armache J.P., Anger A.M., Marquez V., Franckenberg S., Frohlich T.,
RA   Villa E., Berninghausen O., Thomm M., Arnold G.J., Beckmann R.,
RA   Wilson D.N.;
RT   "Promiscuous behaviour of archaeal ribosomal proteins: implications for
RT   eukaryotic ribosome evolution.";
RL   Nucleic Acids Res. 41:1284-1293(2013).
CC   -!- FUNCTION: One of the primary rRNA binding proteins, it binds directly
CC       near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S
CC       subunit. {ECO:0000255|HAMAP-Rule:MF_01325}.
CC   -!- SUBUNIT: Part of the 50S ribosomal subunit (PubMed:23222135). Forms a
CC       cluster with proteins L14 and L24e. {ECO:0000255|HAMAP-Rule:MF_01325,
CC       ECO:0000269|PubMed:23222135}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL3 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01325}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE009950; AAL81949.1; -; Genomic_DNA.
DR   RefSeq; WP_011012966.1; NZ_CP023154.1.
DR   PDB; 4V4N; EM; 9.00 A; C=1-365.
DR   PDB; 4V6U; EM; 6.60 A; BC=1-365.
DR   PDBsum; 4V4N; -.
DR   PDBsum; 4V6U; -.
DR   AlphaFoldDB; Q8TZZ8; -.
DR   SMR; Q8TZZ8; -.
DR   STRING; 186497.PF1825; -.
DR   PRIDE; Q8TZZ8; -.
DR   EnsemblBacteria; AAL81949; AAL81949; PF1825.
DR   GeneID; 41713644; -.
DR   KEGG; pfu:PF1825; -.
DR   PATRIC; fig|186497.12.peg.1896; -.
DR   eggNOG; arCOG04070; Archaea.
DR   HOGENOM; CLU_033361_2_0_2; -.
DR   OMA; HQRTEYN; -.
DR   OrthoDB; 31722at2157; -.
DR   PhylomeDB; Q8TZZ8; -.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR   Gene3D; 4.10.960.10; -; 1.
DR   HAMAP; MF_01325_A; Ribosomal_L3_A; 1.
DR   InterPro; IPR045077; L3_arc_euk.
DR   InterPro; IPR000597; Ribosomal_L3.
DR   InterPro; IPR019928; Ribosomal_L3_arc.
DR   InterPro; IPR019926; Ribosomal_L3_CS.
DR   InterPro; IPR044892; Ribosomal_L3_dom_3_arc_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   PANTHER; PTHR11363; PTHR11363; 1.
DR   Pfam; PF00297; Ribosomal_L3; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   TIGRFAMs; TIGR03626; L3_arch; 1.
DR   PROSITE; PS00474; RIBOSOMAL_L3; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW   RNA-binding; rRNA-binding.
FT   CHAIN           1..365
FT                   /note="50S ribosomal protein L3"
FT                   /id="PRO_0000077218"
FT   REGION          343..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   365 AA;  41390 MW;  298B8443BEB7491E CRC64;
     MGKVHRPRRG SLGFSPRKRA KSIVPRIRSW PKETEVRMLG FAGYKAGMTH ILMIDDEPGL
     TNGKEIFMPV TIIETPPLRV FGIRAYRMGY LGLETATEVI VPDFPLDNYP AKERKGKPKP
     KMTFYKLLER RIATLPKNYT QEMFEQKLGQ LEDMIKEGEI VDVRAIVATQ PWVIKLKKKP
     EVMEYAIGGT SVEEKFNYIK EKLGKELRVG EVLKEGELLD VIAVTKGKGT QGPVKRWGIK
     LRAHKDSKGR RKVGSIGPWH PARVMWTVPM AGQMGFHHRT ELNKRLIAIG ENGKLKLDEN
     TEIEITPKGG FPHYGIVRSD FMMIAGSVPG AIKRIIRVRP AIRPPKKKPP VQRPQITYVS
     VESKQ