ID   RL3_STRP1               Reviewed;         208 AA.
AC   Q9A1X4; Q491Q5;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 128.
DE   RecName: Full=50S ribosomal protein L3 {ECO:0000255|HAMAP-Rule:MF_01325};
GN   Name=rplC {ECO:0000255|HAMAP-Rule:MF_01325};
GN   OrderedLocusNames=SPy_0049, M5005_Spy0044;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: One of the primary rRNA binding proteins, it binds directly
CC       near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S
CC       subunit. {ECO:0000255|HAMAP-Rule:MF_01325}.
CC   -!- SUBUNIT: Part of the 50S ribosomal subunit. Forms a cluster with
CC       proteins L14 and L19. {ECO:0000255|HAMAP-Rule:MF_01325}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL3 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01325}.
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DR   EMBL; AE004092; AAK33182.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ50663.1; -; Genomic_DNA.
DR   RefSeq; NP_268460.1; NC_002737.2.
DR   AlphaFoldDB; Q9A1X4; -.
DR   SMR; Q9A1X4; -.
DR   STRING; 1314.HKU360_00077; -.
DR   DrugBank; DB01256; Retapamulin.
DR   DrugBank; DB06145; Spiramycin.
DR   PaxDb; Q9A1X4; -.
DR   EnsemblBacteria; AAK33182; AAK33182; SPy_0049.
DR   KEGG; spy:SPy_0049; -.
DR   KEGG; spz:M5005_Spy0044; -.
DR   PATRIC; fig|160490.10.peg.44; -.
DR   HOGENOM; CLU_044142_4_1_9; -.
DR   OMA; KRMAGRY; -.
DR   PRO; PR:Q9A1X4; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01325_B; Ribosomal_L3_B; 1.
DR   InterPro; IPR000597; Ribosomal_L3.
DR   InterPro; IPR019927; Ribosomal_L3_bac/org-type.
DR   InterPro; IPR019926; Ribosomal_L3_CS.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   PANTHER; PTHR11229; PTHR11229; 1.
DR   Pfam; PF00297; Ribosomal_L3; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   TIGRFAMs; TIGR03625; L3_bact; 1.
DR   PROSITE; PS00474; RIBOSOMAL_L3; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding;
KW   rRNA-binding.
FT   CHAIN           1..208
FT                   /note="50S ribosomal protein L3"
FT                   /id="PRO_0000077170"
FT   REGION          122..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        111
FT                   /note="I -> T (in Ref. 2; AAZ50663)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   208 AA;  22438 MW;  F327599BB20F0C67 CRC64;
     MTKGILGKKV GMTQIFTESG EFIPVTVIEA TPNVVLQVKT VETDGYEAVQ VGFDDKREVL
     SNKPAKGHVA KANTAPKRFI REFKNIEGLE VGAELSVEQF EAGDVVDVTG ISKGKGFQGV
     IKRHGQSRGP MAHGSRYHRR PGSMGPVAPN RVFKNKRLAG RMGGNRVTVQ NLEIVQVIPE
     KNVILVKGNV PGAKKSLITI KSAVKAAK