RL40_CHICK
ID RL40_CHICK Reviewed; 69 AA.
AC P62985; P02248; P02249; P02250; P14793; P62973; Q29120; Q91887; Q91888;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-AUG-2010, sequence version 2.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Ubiquitin-60S ribosomal protein L40;
DE AltName: Full=Ubiquitin A-52 residue ribosomal protein fusion product 1;
DE Contains:
DE RecName: Full=Ubiquitin;
DE Contains:
DE RecName: Full=60S ribosomal protein L40;
DE AltName: Full=CEP52;
DE Flags: Precursor; Fragment;
GN Name=UBA52; Synonyms=UBCEP2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Spermatid;
RX PubMed=2850543; DOI=10.1093/nar/16.24.11838;
RA Mezquita J., Pau M., Mezquita C.;
RT "cDNA encoding a chicken ubiquitin-fusion protein identical to the
RT corresponding human protein.";
RL Nucleic Acids Res. 16:11838-11838(1988).
CC -!- FUNCTION: [Ubiquitin]: Exists either covalently attached to another
CC protein, or free (unanchored). When covalently bound, it is conjugated
CC to target proteins via an isopeptide bond either as a monomer
CC (monoubiquitin), a polymer linked via different Lys residues of the
CC ubiquitin (polyubiquitin chains) or a linear polymer linked via the
CC initiator Met of the ubiquitin (linear polyubiquitin chains).
CC Polyubiquitin chains, when attached to a target protein, have different
CC functions depending on the Lys residue of the ubiquitin that is linked:
CC Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved
CC in ERAD (endoplasmic reticulum-associated degradation) and in cell-
CC cycle regulation; Lys-29-linked is involved in proteotoxic stress
CC response and cell cycle; Lys-33-linked is involved in kinase
CC modification; Lys-48-linked is involved in protein degradation via the
CC proteasome; Lys-63-linked is involved in endocytosis, DNA-damage
CC responses as well as in signaling processes leading to activation of
CC the transcription factor NF-kappa-B. Linear polymer chains formed via
CC attachment by the initiator Met lead to cell signaling. Ubiquitin is
CC usually conjugated to Lys residues of target proteins, however, in rare
CC cases, conjugation to Cys or Ser residues has been observed. When
CC polyubiquitin is free (unanchored-polyubiquitin), it also has distinct
CC roles, such as in activation of protein kinases, and in signaling (By
CC similarity). {ECO:0000250|UniProtKB:P62987}.
CC -!- FUNCTION: [60S ribosomal protein L40]: Component of the 60S subunit of
CC the ribosome. {ECO:0000250|UniProtKB:P62987}.
CC -!- SUBUNIT: Ribosomal protein L40 is part of the 60S ribosomal subunit.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Ubiquitin]: Cytoplasm {ECO:0000250}. Nucleus
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [60S ribosomal protein L40]: Cytoplasm
CC {ECO:0000250}.
CC -!- MISCELLANEOUS: Ubiquitin is encoded by 4 different genes. Uba52 and
CC Rps27a genes code for a single copy of ubiquitin fused to the ribosomal
CC proteins L40 and S27a, respectively. UBB and UBC genes code for a
CC polyubiquitin precursor with exact head to tail repeats, the number of
CC repeats differ between species and strains.
CC -!- SIMILARITY: In the N-terminal section; belongs to the ubiquitin family.
CC {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the eukaryotic
CC ribosomal protein eL40 family. {ECO:0000305}.
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DR EMBL; X13493; CAA31848.1; -; mRNA.
DR AlphaFoldDB; P62985; -.
DR SMR; P62985; -.
DR VEuPathDB; HostDB:geneid_395958; -.
DR InParanoid; P62985; -.
DR PhylomeDB; P62985; -.
DR Reactome; R-GGA-1227882; TRAF mediated activation of IRF.
DR Reactome; R-GGA-1227888; Negative Regulation of MDA5 signaling.
DR Reactome; R-GGA-1227892; TRAF6 mediated NF-kB activation.
DR Reactome; R-GGA-351465; Fanconi Anemia Pathway in DNA repair.
DR Reactome; R-GGA-353299; RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases.
DR Reactome; R-GGA-353303; Nucleotide Excision Repair.
DR Reactome; R-GGA-433822; NFkB and MAPK activation mediated by TRAF6.
DR Reactome; R-GGA-433871; TRAF6 mediated induction of proinflammatory cytokines.
DR Reactome; R-GGA-434001; TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
DR Reactome; R-GGA-434131; NFkB activation mediated by RIP1 complexed with activated TLR3.
DR Reactome; R-GGA-437980; Activated TAK1 mediates p38 MAP kinase phosphorylation.
DR Reactome; R-GGA-437986; Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation.
DR Reactome; R-GGA-573298; NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0031386; F:protein tag; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0019941; P:modification-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 4.10.1060.50; -; 1.
DR InterPro; IPR038587; L40e_sf.
DR InterPro; IPR001975; Ribosomal_L40e.
DR InterPro; IPR011332; Ribosomal_zn-bd.
DR Pfam; PF01020; Ribosomal_L40e; 1.
DR SMART; SM01377; Ribosomal_L40e; 1.
DR SUPFAM; SSF57829; SSF57829; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Isopeptide bond; Methylation; Nucleus; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Ubl conjugation.
FT CHAIN <1..17
FT /note="Ubiquitin"
FT /id="PRO_0000396441"
FT CHAIN 18..69
FT /note="60S ribosomal protein L40"
FT /id="PRO_0000138755"
FT DOMAIN <1..17
FT /note="Ubiquitin-like"
FT SITE 9
FT /note="Essential for function"
FT SITE 13
FT /note="Interacts with activating enzyme"
FT MOD_RES 39
FT /note="N6,N6,N6-trimethyllysine"
FT /evidence="ECO:0000250|UniProtKB:P62987"
FT CROSSLNK 4
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:P62987"
FT CROSSLNK 17
FT /note="Glycyl lysine isopeptide (Gly-Lys) (interchain with
FT K-? in acceptor proteins)"
FT /evidence="ECO:0000250|UniProtKB:P62987"
FT NON_TER 1
SQ SEQUENCE 69 AA; 8098 MW; 7ABF8DDDE660A429 CRC64;
NIQKESTLHL VLRLRGGIIE PSLRQLAQKY NCDKMICRKC YARLHPRAVN CRKKKCGHTN
NLRPKKKVK
