RL44E_PYRFU
ID RL44E_PYRFU Reviewed; 94 AA.
AC Q8U475;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=50S ribosomal protein L44e {ECO:0000255|HAMAP-Rule:MF_01476};
DE AltName: Full=Large ribosomal subunit protein eL42;
GN Name=rpl44e {ECO:0000255|HAMAP-Rule:MF_01476}; OrderedLocusNames=PF0217;
OS Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=186497;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA DiRuggiero J., Robb F.T.;
RT "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT horikoshii inferred from complete genomic sequences.";
RL Genetics 152:1299-1305(1999).
RN [2] {ECO:0007744|PDB:4V6U}
RP STRUCTURE BY ELECTRON MICROSCOPY (6.60 ANGSTROMS) IN THE 70S RIBOSOME, AND
RP SUBUNIT.
RX PubMed=23222135; DOI=10.1093/nar/gks1259;
RA Armache J.P., Anger A.M., Marquez V., Franckenberg S., Frohlich T.,
RA Villa E., Berninghausen O., Thomm M., Arnold G.J., Beckmann R.,
RA Wilson D.N.;
RT "Promiscuous behaviour of archaeal ribosomal proteins: implications for
RT eukaryotic ribosome evolution.";
RL Nucleic Acids Res. 41:1284-1293(2013).
CC -!- FUNCTION: Binds to the 23S rRNA. {ECO:0000255|HAMAP-Rule:MF_01476}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01476};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01476};
CC -!- SUBUNIT: Part of the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC Rule:MF_01476, ECO:0000269|PubMed:23222135}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL42 family.
CC {ECO:0000255|HAMAP-Rule:MF_01476}.
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DR EMBL; AE009950; AAL80341.1; -; Genomic_DNA.
DR RefSeq; WP_011011330.1; NZ_CP023154.1.
DR PDB; 4V4N; EM; 9.00 A; j=1-94.
DR PDB; 4V6U; EM; 6.60 A; Bj=1-94.
DR PDBsum; 4V4N; -.
DR PDBsum; 4V6U; -.
DR AlphaFoldDB; Q8U475; -.
DR SMR; Q8U475; -.
DR STRING; 186497.PF0217; -.
DR PRIDE; Q8U475; -.
DR EnsemblBacteria; AAL80341; AAL80341; PF0217.
DR GeneID; 41712008; -.
DR KEGG; pfu:PF0217; -.
DR PATRIC; fig|186497.12.peg.225; -.
DR eggNOG; arCOG04109; Archaea.
DR HOGENOM; CLU_114645_3_0_2; -.
DR OMA; CKKHTIH; -.
DR OrthoDB; 106603at2157; -.
DR PhylomeDB; Q8U475; -.
DR Proteomes; UP000001013; Chromosome.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01476; Ribosomal_L44e; 1.
DR InterPro; IPR000552; Ribosomal_L44e.
DR InterPro; IPR011332; Ribosomal_zn-bd.
DR PANTHER; PTHR10369; PTHR10369; 1.
DR Pfam; PF00935; Ribosomal_L44; 1.
DR SUPFAM; SSF57829; SSF57829; 1.
DR PROSITE; PS01172; RIBOSOMAL_L44E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Metal-binding; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; RNA-binding; rRNA-binding; Zinc; Zinc-finger.
FT CHAIN 1..94
FT /note="50S ribosomal protein L44e"
FT /id="PRO_0000149154"
FT ZN_FING 11..74
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01476"
FT BINDING 11
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01476"
FT BINDING 14
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01476"
FT BINDING 71
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01476"
FT BINDING 74
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01476"
SQ SEQUENCE 94 AA; 11201 MW; 3EC8737B8D6297FE CRC64;
MKYPKQIRTY CPFCKKHTIH KVERVKKRPR SELSAGQRRF RRILKGYGGF PRPKPEGREK
PVKKLDLRFR CTECGKAHTR GRGFRVKKFE LVEG
