RL44_CRYNJ
ID RL44_CRYNJ Reviewed; 106 AA.
AC P0CQ50; Q55LE4; Q5KA45; Q9HF88;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 45.
DE RecName: Full=60S ribosomal protein L44;
DE AltName: Full=60S ribosomal protein L41;
GN Name=RPL44; Synonyms=RPL41; OrderedLocusNames=CNJ03120;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
RN [2]
RP VARIANT LEU-56.
RC STRAIN=B-3501, B-4467, JEC21 / ATCC MYA-565, JEC39, JEC55, and JEC60;
RX PubMed=11054820;
RX DOI=10.1002/1097-0061(200011)16:15<1397::aid-yea636>3.0.co;2-1;
RA Varma A., Kwon-Chung K.J.;
RT "Characterization of the L41 gene in Cryptococcus neoformans: its
RT application as a selectable transformation marker for cycloheximide
RT resistance.";
RL Yeast 16:1397-1403(2000).
CC -!- MISCELLANEOUS: Cycloheximide sensitive type.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL42 family.
CC {ECO:0000305}.
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DR EMBL; AE017350; AAW45874.2; -; Genomic_DNA.
DR RefSeq; XP_567391.1; XM_567391.1.
DR AlphaFoldDB; P0CQ50; -.
DR SMR; P0CQ50; -.
DR STRING; 214684.P0CQ50; -.
DR EnsemblFungi; AAW45874; AAW45874; CNJ03120.
DR VEuPathDB; FungiDB:CNJ03120; -.
DR InParanoid; P0CQ50; -.
DR OrthoDB; 1392093at2759; -.
DR Proteomes; UP000002149; Chromosome 10.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR GO; GO:0046898; P:response to cycloheximide; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR InterPro; IPR000552; Ribosomal_L44e.
DR InterPro; IPR011332; Ribosomal_zn-bd.
DR PANTHER; PTHR10369; PTHR10369; 1.
DR Pfam; PF00935; Ribosomal_L44; 1.
DR SUPFAM; SSF57829; SSF57829; 1.
DR PROSITE; PS01172; RIBOSOMAL_L44E; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; Cycloheximide resistance; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..106
FT /note="60S ribosomal protein L44"
FT /id="PRO_0000149138"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..26
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 56
FT /note="P -> L (in strain: JEC39, JEC55 and JEC60; confers
FT resistance to cycloheximide, an inhibitor of polypeptide
FT elongation)"
FT /evidence="ECO:0000269|PubMed:11054820"
SQ SEQUENCE 106 AA; 12146 MW; 8D8AF884CB74D6A8 CRC64;
MVNIPKTRRT YCKGKACRKH TPHKVTQYKK GKDSLSAQGK RRYDRKQSGY GGQTKPVFHK
KAKTTKKVVL RLECTVCKTK HQLALKRCKH FELGGDKKQR GAAISF
