RL44_SCHPO
ID RL44_SCHPO Reviewed; 106 AA.
AC Q9UTI8;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=60S ribosomal protein L42;
GN Name=rpl42; Synonyms=rpl36a; ORFNames=SPAC15E1.03;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP METHYLATION AT LYS-55, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=20444689; DOI=10.1074/jbc.m110.132274;
RA Shirai A., Sadaie M., Shinmyozu K., Nakayama J.;
RT "Methylation of ribosomal protein L42 regulates ribosomal function and
RT stress-adapted cell growth.";
RL J. Biol. Chem. 285:22448-22460(2010).
RN [4]
RP MUTAGENESIS OF PRO-56.
RX PubMed=28775286; DOI=10.1038/s41598-017-07647-1;
RA Villahermosa D., Fleck O.;
RT "Elp3 and Dph3 of Schizosaccharomyces pombe mediate cellular stress
RT responses through tRNALysUUU modifications.";
RL Sci. Rep. 7:7225-7225(2017).
CC -!- SUBUNIT: Component of the large ribosomal subunit.
CC {ECO:0000250|UniProtKB:P0CX27}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL42 family.
CC {ECO:0000305}.
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DR EMBL; CU329670; CAB52422.1; -; Genomic_DNA.
DR PIR; T37718; T37718.
DR RefSeq; NP_594304.1; NM_001019727.2.
DR AlphaFoldDB; Q9UTI8; -.
DR SMR; Q9UTI8; -.
DR BioGRID; 279238; 8.
DR STRING; 4896.SPAC15E1.03.1; -.
DR iPTMnet; Q9UTI8; -.
DR MaxQB; Q9UTI8; -.
DR PaxDb; Q9UTI8; -.
DR EnsemblFungi; SPAC15E1.03.1; SPAC15E1.03.1:pep; SPAC15E1.03.
DR GeneID; 2542789; -.
DR KEGG; spo:SPAC15E1.03; -.
DR PomBase; SPAC15E1.03; rpl42.
DR VEuPathDB; FungiDB:SPAC15E1.03; -.
DR eggNOG; KOG3464; Eukaryota.
DR HOGENOM; CLU_114645_2_1_1; -.
DR InParanoid; Q9UTI8; -.
DR OMA; CKKHTIH; -.
DR PhylomeDB; Q9UTI8; -.
DR Reactome; R-SPO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-SPO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-SPO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-SPO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-SPO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-SPO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:Q9UTI8; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; ISO:PomBase.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:PomBase.
DR GO; GO:0002181; P:cytoplasmic translation; ISO:PomBase.
DR InterPro; IPR000552; Ribosomal_L44e.
DR InterPro; IPR011332; Ribosomal_zn-bd.
DR PANTHER; PTHR10369; PTHR10369; 1.
DR Pfam; PF00935; Ribosomal_L44; 1.
DR SUPFAM; SSF57829; SSF57829; 1.
DR PROSITE; PS01172; RIBOSOMAL_L44E; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Methylation; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..106
FT /note="60S ribosomal protein L42"
FT /id="PRO_0000149145"
FT REGION 25..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 55
FT /note="N6-methyllysine; by set13"
FT /evidence="ECO:0000269|PubMed:20444689"
FT MUTAGEN 56
FT /note="P->Q: Sensitive to methyl methanesulfonate (MMS,
FT causes DNA breaks) and hydroxyurea (HU, ribonucleotide
FT reductase inhibitor); simultaneous disruption of dph3 or
FT elp3 suppresses MMS sensitivity, and simultaneous
FT disruption of elp3 suppresses HU sensitivity."
FT /evidence="ECO:0000269|PubMed:28775286"
SQ SEQUENCE 106 AA; 12206 MW; 4AC751BEBC2D4869 CRC64;
MVNIPKTRKT YCPGKNCRKH TVHRVTQYKK GPDSKLAQGK RRYDRKQSGF GGQTKPVFHK
KAKVTKKVVL RLECVSCKYK NQLVLKRCKH FELGGEKKTK GAAIQF
