RL4A_SCHPO
ID RL4A_SCHPO Reviewed; 363 AA.
AC P35679; O94253;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 14-AUG-2001, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=60S ribosomal protein L4-A;
DE AltName: Full=L2;
GN Name=rpl402; Synonyms=rpl2, rpl4, rpl4a; ORFNames=SPBP8B7.03c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=1913;
RX PubMed=8367312; DOI=10.1093/nar/21.16.3900;
RA Presutti C., Villa T., Bozzoni I.;
RT "The primary sequence of the Schizosaccharomyces pombe protein homologous
RT to S.cerevisiae ribosomal protein L2.";
RL Nucleic Acids Res. 21:3900-3900(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- MISCELLANEOUS: There are two genes for L4 in S.pombe.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL4 family.
CC {ECO:0000305}.
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DR EMBL; X73146; CAA51666.1; -; Genomic_DNA.
DR EMBL; CU329671; CAA21788.1; -; Genomic_DNA.
DR PIR; S41640; S41640.
DR PIR; T40797; T40797.
DR RefSeq; NP_596510.1; NM_001022431.2.
DR AlphaFoldDB; P35679; -.
DR SMR; P35679; -.
DR BioGRID; 277855; 11.
DR IntAct; P35679; 2.
DR STRING; 4896.SPBP8B7.03c.1; -.
DR iPTMnet; P35679; -.
DR MaxQB; P35679; -.
DR PaxDb; P35679; -.
DR PRIDE; P35679; -.
DR EnsemblFungi; SPBP8B7.03c.1; SPBP8B7.03c.1:pep; SPBP8B7.03c.
DR GeneID; 2541344; -.
DR KEGG; spo:SPBP8B7.03c; -.
DR PomBase; SPBP8B7.03c; rpl402.
DR VEuPathDB; FungiDB:SPBP8B7.03c; -.
DR eggNOG; KOG1475; Eukaryota.
DR HOGENOM; CLU_026535_0_1_1; -.
DR InParanoid; P35679; -.
DR OMA; WHQKVNV; -.
DR PhylomeDB; P35679; -.
DR Reactome; R-SPO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-SPO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-SPO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-SPO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-SPO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-SPO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P35679; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; ISO:PomBase.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:PomBase.
DR GO; GO:0002181; P:cytoplasmic translation; ISO:PomBase.
DR Gene3D; 3.40.1370.10; -; 1.
DR InterPro; IPR025755; Ribos_L4_C_dom.
DR InterPro; IPR002136; Ribosomal_L4/L1e.
DR InterPro; IPR013000; Ribosomal_L4/L1e_euk/arc_CS.
DR InterPro; IPR023574; Ribosomal_L4_dom_sf.
DR InterPro; IPR045240; Ribosomal_L4_euk/arch.
DR PANTHER; PTHR19431; PTHR19431; 1.
DR Pfam; PF14374; Ribos_L4_asso_C; 1.
DR Pfam; PF00573; Ribosomal_L4; 1.
DR SUPFAM; SSF52166; SSF52166; 1.
DR PROSITE; PS00939; RIBOSOMAL_L1E; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..363
FT /note="60S ribosomal protein L4-A"
FT /id="PRO_0000129365"
FT MOD_RES 87
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT CONFLICT 12
FT /note="S -> N (in Ref. 1; CAA51666)"
FT /evidence="ECO:0000305"
FT CONFLICT 22
FT /note="I -> L (in Ref. 1; CAA51666)"
FT /evidence="ECO:0000305"
FT CONFLICT 85
FT /note="H -> S (in Ref. 1; CAA51666)"
FT /evidence="ECO:0000305"
FT CONFLICT 104
FT /note="P -> S (in Ref. 1; CAA51666)"
FT /evidence="ECO:0000305"
FT CONFLICT 124..125
FT /note="IS -> TC (in Ref. 1; CAA51666)"
FT /evidence="ECO:0000305"
FT CONFLICT 181
FT /note="V -> I (in Ref. 1; CAA51666)"
FT /evidence="ECO:0000305"
FT CONFLICT 197
FT /note="R -> A (in Ref. 1; CAA51666)"
FT /evidence="ECO:0000305"
FT CONFLICT 272
FT /note="Q -> E (in Ref. 1; CAA51666)"
FT /evidence="ECO:0000305"
FT CONFLICT 278
FT /note="F -> G (in Ref. 1; CAA51666)"
FT /evidence="ECO:0000305"
FT CONFLICT 281..282
FT /note="EN -> DEI (in Ref. 1; CAA51666)"
FT /evidence="ECO:0000305"
FT CONFLICT 355..356
FT /note="KF -> NS (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 363 AA; 39767 MW; 2106AA8038328618 CRC64;
MAAARPTVSI YSKDGSVSSE TIALPFVFKA PIRPDLVRSV HTAVAKNKRQ PYAVSEKAGH
QTSAESWGTG RALARIPRVG GGGTHRSGQA AFGNMCRSGR MFAPTKTWRK WHVKVNQNEK
RYAISSAVAA SGVPSLLLAR GHRIEEIPEV PLVVDDAVQS FQKTKEAVAL LKEIKAYRDV
VKVANSRKLR AGKGKLRNRR HVQRRGPLVV FNEDAGIVKA FRNIPGVEIV NVRRLNLLQL
APGGHLGRFV IWTKSAFGLL DSVFGSTTEA AQLKKNYFLP ENIISNADVT RLINSDEIQS
IVKAAGPSRV KRAHVQKKNP LKNKAVLARL NPYAKAYKAN VKLNTGKTPK AAGEKFLTVL
HEN
