ID   RL4A_XENLA              Reviewed;         396 AA.
AC   P08429; Q7ZY88; Q91843;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=60S ribosomal protein L4-A;
DE   AltName: Full=L1A;
GN   Name=rpl4-a; Synonyms=rpl-4, rpl1a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=3841512; DOI=10.1002/j.1460-2075.1985.tb04107.x;
RA   Loreni F., Ruberti I., Bozzoni I., Pierandrei-Amaldi P., Amaldi F.;
RT   "Nucleotide sequence of the L1 ribosomal protein gene of Xenopus laevis:
RT   remarkable sequence homology among introns.";
RL   EMBO J. 4:3483-3488(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula, and Tail bud;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC       large ribonucleoprotein complex responsible for the synthesis of
CC       proteins in the cell. {ECO:0000250|UniProtKB:P36578}.
CC   -!- SUBUNIT: Component of the large ribosomal subunit.
CC       {ECO:0000250|UniProtKB:P36578}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P36578}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL4 family.
CC       {ECO:0000305}.
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DR   EMBL; X05216; CAA28843.1; -; mRNA.
DR   EMBL; X06552; CAA29796.1; -; Genomic_DNA.
DR   EMBL; BC043895; AAH43895.1; -; mRNA.
DR   EMBL; BC106315; AAI06316.1; -; mRNA.
DR   PIR; A24579; R5XL1A.
DR   RefSeq; NP_001080545.1; NM_001087076.1.
DR   AlphaFoldDB; P08429; -.
DR   SMR; P08429; -.
DR   BioGRID; 98479; 2.
DR   IntAct; P08429; 1.
DR   DNASU; 380237; -.
DR   GeneID; 380237; -.
DR   KEGG; xla:380237; -.
DR   CTD; 380237; -.
DR   Xenbase; XB-GENE-968399; rpl4.L.
DR   OrthoDB; 878848at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 380237; Expressed in lung and 19 other tissues.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   Gene3D; 3.40.1370.10; -; 1.
DR   InterPro; IPR025755; Ribos_L4_C_dom.
DR   InterPro; IPR002136; Ribosomal_L4/L1e.
DR   InterPro; IPR013000; Ribosomal_L4/L1e_euk/arc_CS.
DR   InterPro; IPR023574; Ribosomal_L4_dom_sf.
DR   InterPro; IPR045240; Ribosomal_L4_euk/arch.
DR   PANTHER; PTHR19431; PTHR19431; 1.
DR   Pfam; PF14374; Ribos_L4_asso_C; 1.
DR   Pfam; PF00573; Ribosomal_L4; 1.
DR   SUPFAM; SSF52166; SSF52166; 1.
DR   PROSITE; PS00939; RIBOSOMAL_L1E; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT   CHAIN           1..396
FT                   /note="60S ribosomal protein L4-A"
FT                   /id="PRO_0000129354"
FT   REGION          352..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        246
FT                   /note="P -> L (in Ref. 1; CAA29796)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        392
FT                   /note="A -> P (in Ref. 2; CAA28843)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   396 AA;  44909 MW;  2DA0FB6920A186BC CRC64;
     MAVSMACARP LISVYSEKGE SSGKNVTMPA VFRAPIRPDI VNFVHTNLRK NNRQPYAVSK
     LAGHQTSAES WGTGRAVARI PRVRGGGTHR SGQGAFGNMC RGGRMFAPTK TWRRWHRRVN
     TTQKRYAVCS ALAASALPAL IMSKGHRIEE IPEVPLVVED KVESYKKTKE AVLLLKKLKA
     WNDIKKVYAS QRMRAGKGKM RNRRRIQRRG PCVIYNENNG LVKAFRNIPG ITLLNVSKLN
     LLRLAPGGHV GRFCIWTESA FRKLDDLYGT WRKSAKLKAD YNLPMHKMTN TDLTRILKSQ
     EIQRALRAPN KKVKRRELKK NPLKNLRIMM RLNPYAKTAR RHAILQQLEN IKAKEKKPDD
     GKPKAKKPLD AKTKMIKLAK AKKRQAREAA KAAETK