RL4_ENTFA
ID RL4_ENTFA Reviewed; 207 AA.
AC Q839G3;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=50S ribosomal protein L4 {ECO:0000255|HAMAP-Rule:MF_01328};
GN Name=rplD {ECO:0000255|HAMAP-Rule:MF_01328}; OrderedLocusNames=EF_0207;
OS Enterococcus faecalis (strain ATCC 700802 / V583).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=226185;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700802 / V583;
RX PubMed=12663927; DOI=10.1126/science.1080613;
RA Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT faecalis.";
RL Science 299:2071-2074(2003).
CC -!- FUNCTION: One of the primary rRNA binding proteins, this protein
CC initially binds near the 5'-end of the 23S rRNA. It is important during
CC the early stages of 50S assembly. It makes multiple contacts with
CC different domains of the 23S rRNA in the assembled 50S subunit and
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_01328}.
CC -!- FUNCTION: Forms part of the polypeptide exit tunnel.
CC {ECO:0000255|HAMAP-Rule:MF_01328}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC Rule:MF_01328}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL4 family.
CC {ECO:0000255|HAMAP-Rule:MF_01328}.
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DR EMBL; AE016830; AAO80076.1; -; Genomic_DNA.
DR RefSeq; NP_814005.1; NC_004668.1.
DR RefSeq; WP_010774252.1; NZ_KE136524.1.
DR PDB; 6WU9; EM; 2.90 A; E=2-207.
DR PDB; 7P7Q; EM; 2.40 A; I=1-207.
DR PDB; 7P7R; EM; 2.90 A; I=1-207.
DR PDB; 7P7S; EM; 3.00 A; I=1-207.
DR PDB; 7P7T; EM; 2.90 A; I=1-207.
DR PDB; 7P7U; EM; 3.10 A; I=1-207.
DR PDBsum; 6WU9; -.
DR PDBsum; 7P7Q; -.
DR PDBsum; 7P7R; -.
DR PDBsum; 7P7S; -.
DR PDBsum; 7P7T; -.
DR PDBsum; 7P7U; -.
DR AlphaFoldDB; Q839G3; -.
DR SMR; Q839G3; -.
DR STRING; 226185.EF_0207; -.
DR EnsemblBacteria; AAO80076; AAO80076; EF_0207.
DR KEGG; efa:EF0207; -.
DR PATRIC; fig|226185.45.peg.59; -.
DR eggNOG; COG0088; Bacteria.
DR HOGENOM; CLU_041575_5_2_9; -.
DR OMA; PQVHILE; -.
DR Proteomes; UP000001415; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1370.10; -; 1.
DR HAMAP; MF_01328_B; Ribosomal_L4_B; 1.
DR InterPro; IPR002136; Ribosomal_L4/L1e.
DR InterPro; IPR023574; Ribosomal_L4_dom_sf.
DR InterPro; IPR013005; Ribosomal_uL4/L1e.
DR PANTHER; PTHR10746; PTHR10746; 1.
DR Pfam; PF00573; Ribosomal_L4; 1.
DR SUPFAM; SSF52166; SSF52166; 1.
DR TIGRFAMs; TIGR03953; rplD_bact; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW RNA-binding; rRNA-binding.
FT CHAIN 1..207
FT /note="50S ribosomal protein L4"
FT /id="PRO_0000129218"
FT REGION 49..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 3..7
FT /evidence="ECO:0007829|PDB:6WU9"
FT STRAND 16..18
FT /evidence="ECO:0007829|PDB:6WU9"
FT TURN 21..23
FT /evidence="ECO:0007829|PDB:6WU9"
FT STRAND 24..26
FT /evidence="ECO:0007829|PDB:6WU9"
FT HELIX 30..42
FT /evidence="ECO:0007829|PDB:6WU9"
FT TURN 54..56
FT /evidence="ECO:0007829|PDB:6WU9"
FT STRAND 67..72
FT /evidence="ECO:0007829|PDB:6WU9"
FT STRAND 78..80
FT /evidence="ECO:0007829|PDB:6WU9"
FT HELIX 103..118
FT /evidence="ECO:0007829|PDB:6WU9"
FT TURN 119..121
FT /evidence="ECO:0007829|PDB:6WU9"
FT STRAND 123..127
FT /evidence="ECO:0007829|PDB:6WU9"
FT HELIX 136..145
FT /evidence="ECO:0007829|PDB:6WU9"
FT STRAND 152..156
FT /evidence="ECO:0007829|PDB:6WU9"
FT HELIX 161..167
FT /evidence="ECO:0007829|PDB:6WU9"
FT STRAND 173..177
FT /evidence="ECO:0007829|PDB:6WU9"
FT HELIX 183..188
FT /evidence="ECO:0007829|PDB:6WU9"
FT STRAND 189..195
FT /evidence="ECO:0007829|PDB:6WU9"
FT HELIX 196..206
FT /evidence="ECO:0007829|PDB:6WU9"
SQ SEQUENCE 207 AA; 22521 MW; 85D26188172CE4CA CRC64;
MPNVALFKQD GTQNGEITLN EEIFGIEPNE SVVYDAIIMQ RASLRQGTHA VKNRSAVRGG
GRKPWRQKGT GRARQGSIRS PQWRGGGVVF GPTPRSYSYK FPKKVRRLAM KSVLSDKVAE
NNLVAVEGLS FDAPKTKEFK QVLANLSIDT KVLVVLENGN DFAALSARNL PNVSVVTSDN
VSVLDVVSAN KVLATQTALT QIEEVLA
