RL4_HALSA
ID RL4_HALSA Reviewed; 250 AA.
AC Q9HPD3; P05967; Q06845;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=50S ribosomal protein L4 {ECO:0000255|HAMAP-Rule:MF_01328};
GN Name=rpl4 {ECO:0000255|HAMAP-Rule:MF_01328}; OrderedLocusNames=VNG_1690G;
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium.
OX NCBI_TaxID=64091;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8241282; DOI=10.1016/0167-4781(93)90169-e;
RA Yuki Y., Kanechika R., Itoh T.;
RT "Nucleotide sequence of the genes encoding the L3, L4, and L23 equivalent
RT ribosomal proteins from the archaebacterium Halobacterium halobium.";
RL Biochim. Biophys. Acta 1216:335-338(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN [3]
RP PROTEIN SEQUENCE OF 1-33.
RX PubMed=6467081; DOI=10.1139/o84-058;
RA Matheson A.T., Yaguchi M., Christensen P., Rollin C.F., Hasnain S.;
RT "Purification, properties, and N-terminal amino acid sequence of certain
RT 50S ribosomal subunit proteins from the archaebacterium Halobacterium
RT cutirubrum.";
RL Can. J. Biochem. Cell Biol. 62:426-433(1984).
CC -!- FUNCTION: One of the primary rRNA binding proteins, this protein
CC initially binds near the 5'-end of the 23S rRNA. It is important during
CC the early stages of 50S assembly. It makes multiple contacts with
CC different domains of the 23S rRNA in the assembled 50S subunit and
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_01328}.
CC -!- FUNCTION: Forms part of the polypeptide exit tunnel.
CC {ECO:0000255|HAMAP-Rule:MF_01328}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL4 family.
CC {ECO:0000255|HAMAP-Rule:MF_01328}.
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DR EMBL; AB006961; BAA22271.1; -; Genomic_DNA.
DR EMBL; AE004437; AAG19937.1; -; Genomic_DNA.
DR PIR; E84321; E84321.
DR PIR; S43421; S43421.
DR RefSeq; WP_010903235.1; NC_002607.1.
DR AlphaFoldDB; Q9HPD3; -.
DR SMR; Q9HPD3; -.
DR STRING; 64091.VNG_1690G; -.
DR PaxDb; Q9HPD3; -.
DR EnsemblBacteria; AAG19937; AAG19937; VNG_1690G.
DR GeneID; 5954229; -.
DR KEGG; hal:VNG_1690G; -.
DR PATRIC; fig|64091.14.peg.1289; -.
DR HOGENOM; CLU_026535_0_0_2; -.
DR InParanoid; Q9HPD3; -.
DR OMA; WHQKVNV; -.
DR OrthoDB; 65833at2157; -.
DR PhylomeDB; Q9HPD3; -.
DR Proteomes; UP000000554; Chromosome.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1370.10; -; 1.
DR HAMAP; MF_01328_A; Ribosomal_L4_A; 1.
DR InterPro; IPR002136; Ribosomal_L4/L1e.
DR InterPro; IPR013000; Ribosomal_L4/L1e_euk/arc_CS.
DR InterPro; IPR023574; Ribosomal_L4_dom_sf.
DR InterPro; IPR045240; Ribosomal_L4_euk/arch.
DR InterPro; IPR019970; Ribosomall_L4-archaea.
DR PANTHER; PTHR19431; PTHR19431; 1.
DR Pfam; PF00573; Ribosomal_L4; 1.
DR SUPFAM; SSF52166; SSF52166; 1.
DR TIGRFAMs; TIGR03672; rpl4p_arch; 1.
DR PROSITE; PS00939; RIBOSOMAL_L1E; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; RNA-binding; rRNA-binding.
FT CHAIN 1..250
FT /note="50S ribosomal protein L4"
FT /id="PRO_0000129330"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 24..25
FT /note="EP -> TN (in Ref. 1; BAA22271)"
FT /evidence="ECO:0000305"
FT CONFLICT 32
FT /note="K -> N (in Ref. 1; BAA22271)"
FT /evidence="ECO:0000305"
FT CONFLICT 73..84
FT /note="ANGQGARVPQTV -> QTGRVRRAPDSF (in Ref. 1; BAA22271)"
FT /evidence="ECO:0000305"
FT CONFLICT 98..99
FT /note="HG -> RS (in Ref. 1; BAA22271)"
FT /evidence="ECO:0000305"
FT CONFLICT 108..109
FT /note="KA -> QL (in Ref. 1; BAA22271)"
FT /evidence="ECO:0000305"
FT CONFLICT 113..126
FT /note="AAVAATTDSELVAD -> SALLATADHDSELA (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 173..174
FT /note="GR -> AA (in Ref. 1; BAA22271)"
FT /evidence="ECO:0000305"
FT CONFLICT 182
FT /note="T -> E (in Ref. 1; BAA22271)"
FT /evidence="ECO:0000305"
FT CONFLICT 207
FT /note="Missing (in Ref. 1; BAA22271)"
FT /evidence="ECO:0000305"
FT CONFLICT 218
FT /note="T -> S (in Ref. 1; BAA22271)"
FT /evidence="ECO:0000305"
FT CONFLICT 231
FT /note="Missing (in Ref. 1; BAA22271)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 250 AA; 26658 MW; C546488B6DD4642E CRC64;
MQVTVRDLDG DDAGTLDLPR VFEEPVRPDL VKRAVLAAQA NRTQEYGADE YAGLRTTAES
QGSGRGMAHV PKANGQGARV PQTVGGRKAH PPKAEKDHGL DVNDKERKAA VRAAVAATTD
SELVADRGHN FDDDVEFPLV VSDDFEDLVK TQDVVSLLEA LGVHADIERA DEGRTVRAGQ
GTLRGRKYQE PTSILFVTAS ESGPSTAARN LAGVDVATGR EVNAEDLAPG AEPGRLTVWT
ESAVEEVAQR
