1433Z_CHICK
ID 1433Z_CHICK Reviewed; 245 AA.
AC Q5ZKC9;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=14-3-3 protein zeta;
GN Name=YWHAZ; ORFNames=RCJMB04_11l21;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Adapter protein implicated in the regulation of a large
CC spectrum of both general and specialized signaling pathways. Binds to a
CC large number of partners, usually by recognition of a phosphoserine or
CC phosphothreonine motif. Binding generally results in the modulation of
CC the activity of the binding partner (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the 14-3-3 family. {ECO:0000305}.
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DR EMBL; AJ720155; CAG31814.1; -; mRNA.
DR RefSeq; NP_001026514.1; NM_001031343.1.
DR AlphaFoldDB; Q5ZKC9; -.
DR SMR; Q5ZKC9; -.
DR BioGRID; 685627; 3.
DR IntAct; Q5ZKC9; 1.
DR STRING; 9031.ENSGALP00000028746; -.
DR PaxDb; Q5ZKC9; -.
DR PRIDE; Q5ZKC9; -.
DR Ensembl; ENSGALT00000059383; ENSGALP00000049152; ENSGALG00000031387.
DR Ensembl; ENSGALT00000077278; ENSGALP00000048283; ENSGALG00000031387.
DR Ensembl; ENSGALT00000084548; ENSGALP00000061526; ENSGALG00000031387.
DR Ensembl; ENSGALT00000086950; ENSGALP00000064772; ENSGALG00000031387.
DR GeneID; 425619; -.
DR KEGG; gga:425619; -.
DR CTD; 7534; -.
DR VEuPathDB; HostDB:geneid_425619; -.
DR eggNOG; KOG0841; Eukaryota.
DR GeneTree; ENSGT01050000244817; -.
DR HOGENOM; CLU_058290_1_0_1; -.
DR InParanoid; Q5ZKC9; -.
DR OMA; ERVCQDV; -.
DR OrthoDB; 1176818at2759; -.
DR PhylomeDB; Q5ZKC9; -.
DR TreeFam; TF102003; -.
DR Reactome; R-GGA-3769402; Deactivation of the beta-catenin transactivating complex.
DR Reactome; R-GGA-392517; Rap1 signalling.
DR Reactome; R-GGA-430116; GP1b-IX-V activation signalling.
DR Reactome; R-GGA-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-GGA-9614399; Regulation of localization of FOXO transcription factors.
DR PRO; PR:Q5ZKC9; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000031387; Expressed in brain and 13 other tissues.
DR ExpressionAtlas; Q5ZKC9; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0098686; C:hippocampal mossy fiber to CA3 synapse; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0051683; P:establishment of Golgi localization; IEA:Ensembl.
DR GO; GO:0090168; P:Golgi reassembly; IEA:Ensembl.
DR GO; GO:0030324; P:lung development; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR GO; GO:0006468; P:protein phosphorylation; IEA:Ensembl.
DR GO; GO:0006605; P:protein targeting; IEA:Ensembl.
DR GO; GO:0010941; P:regulation of cell death; IEA:Ensembl.
DR GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0090128; P:regulation of synapse maturation; IEA:Ensembl.
DR GO; GO:0003016; P:respiratory system process; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:0008039; P:synaptic target recognition; IEA:Ensembl.
DR GO; GO:0035148; P:tube formation; IEA:Ensembl.
DR Gene3D; 1.20.190.20; -; 1.
DR InterPro; IPR000308; 14-3-3.
DR InterPro; IPR023409; 14-3-3_CS.
DR InterPro; IPR036815; 14-3-3_dom_sf.
DR InterPro; IPR023410; 14-3-3_domain.
DR PANTHER; PTHR18860; PTHR18860; 1.
DR Pfam; PF00244; 14-3-3; 1.
DR PIRSF; PIRSF000868; 14-3-3; 1.
DR PRINTS; PR00305; 1433ZETA.
DR SMART; SM00101; 14_3_3; 1.
DR SUPFAM; SSF48445; SSF48445; 1.
DR PROSITE; PS00796; 1433_1; 1.
DR PROSITE; PS00797; 1433_2; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..245
FT /note="14-3-3 protein zeta"
FT /id="PRO_0000058632"
FT SITE 56
FT /note="Interaction with phosphoserine on interacting
FT protein"
FT /evidence="ECO:0000250"
FT SITE 127
FT /note="Interaction with phosphoserine on interacting
FT protein"
FT /evidence="ECO:0000250"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250"
FT MOD_RES 184
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 245 AA; 27775 MW; F2A813EE4B23B42D CRC64;
MDKNELVQKA KLAEQAERYD DMASCMKSVT EQGAELSNEE RNLLSVAYKN VVGARRSSWR
VVSSIEQKTE GAEKKQQMAR EYREKIETEL RDICNDVLSL LEKFLIPNAS QAESKVFYLK
MKGDYYRYLA EVAAGDDKKG IVEQSQQAYQ EAFEISKKEM QPTHPIRLGL ALNFSVFYYE
ILNSPEKACS LAKTAFDEAI AELDTLSEES YKDSTLIMQL LRDNLTLWTS DTQGDEAEAG
EGGEN
