RL4_MYCTU
ID RL4_MYCTU Reviewed; 223 AA.
AC P9WH85; L0T4L8; O06045; P60729; P95050;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 44.
DE RecName: Full=50S ribosomal protein L4 {ECO:0000255|HAMAP-Rule:MF_01328};
GN Name=rplD {ECO:0000255|HAMAP-Rule:MF_01328}; OrderedLocusNames=Rv0702;
GN ORFNames=MTCY210.21;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: One of the primary rRNA binding proteins, this protein
CC initially binds near the 5'-end of the 23S rRNA. It is important during
CC the early stages of 50S assembly. It makes multiple contacts with
CC different domains of the 23S rRNA in the assembled 50S subunit and
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_01328}.
CC -!- FUNCTION: Forms part of the polypeptide exit tunnel.
CC {ECO:0000255|HAMAP-Rule:MF_01328}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC Rule:MF_01328}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL4 family.
CC {ECO:0000255|HAMAP-Rule:MF_01328}.
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DR EMBL; AL123456; CCP43446.1; -; Genomic_DNA.
DR PIR; A70642; A70642.
DR RefSeq; NP_215216.1; NC_000962.3.
DR RefSeq; WP_003403580.1; NZ_NVQJ01000007.1.
DR PDB; 5V7Q; EM; 3.70 A; E=1-223.
DR PDB; 7KGB; EM; 2.70 A; E=1-223.
DR PDB; 7MSC; EM; 2.97 A; E=1-223.
DR PDB; 7MSH; EM; 3.23 A; E=1-223.
DR PDB; 7MSM; EM; 2.79 A; E=1-223.
DR PDB; 7MSZ; EM; 3.10 A; E=1-223.
DR PDB; 7MT2; EM; 2.76 A; E=1-223.
DR PDB; 7MT3; EM; 2.80 A; E=1-223.
DR PDB; 7MT7; EM; 2.71 A; E=1-223.
DR PDBsum; 5V7Q; -.
DR PDBsum; 7KGB; -.
DR PDBsum; 7MSC; -.
DR PDBsum; 7MSH; -.
DR PDBsum; 7MSM; -.
DR PDBsum; 7MSZ; -.
DR PDBsum; 7MT2; -.
DR PDBsum; 7MT3; -.
DR PDBsum; 7MT7; -.
DR AlphaFoldDB; P9WH85; -.
DR SMR; P9WH85; -.
DR STRING; 83332.Rv0702; -.
DR PaxDb; P9WH85; -.
DR DNASU; 888345; -.
DR GeneID; 888345; -.
DR KEGG; mtu:Rv0702; -.
DR TubercuList; Rv0702; -.
DR eggNOG; COG0088; Bacteria.
DR OMA; PQVHILE; -.
DR PhylomeDB; P9WH85; -.
DR PRO; PR:P9WH85; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1370.10; -; 1.
DR HAMAP; MF_01328_B; Ribosomal_L4_B; 1.
DR InterPro; IPR002136; Ribosomal_L4/L1e.
DR InterPro; IPR023574; Ribosomal_L4_dom_sf.
DR InterPro; IPR013005; Ribosomal_uL4/L1e.
DR PANTHER; PTHR10746; PTHR10746; 1.
DR Pfam; PF00573; Ribosomal_L4; 1.
DR SUPFAM; SSF52166; SSF52166; 1.
DR TIGRFAMs; TIGR03953; rplD_bact; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW RNA-binding; rRNA-binding.
FT CHAIN 1..223
FT /note="50S ribosomal protein L4"
FT /id="PRO_0000129247"
FT REGION 49..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 223 AA; 23743 MW; E9AF8F30E35A66AB CRC64;
MAAQEQKTLK IDVKTPAGKV DGAIELPAEL FDVPANIALM HQVVTAQRAA ARQGTHSTKT
RGEVSGGGRK PYRQKGTGRA RQGSTRAPQF TGGGVVHGPK PRDYSQRTPK KMIAAALRGA
LSDRARNGRI HAITELVEGQ NPSTKSARAF LASLTERKQV LVVIGRSDEA GAKSVRNLPG
VHILAPDQLN TYDVLRADDV VFSVEALNAY IAANTTTSEE VSA
