RL4_PSEAE
ID RL4_PSEAE Reviewed; 200 AA.
AC Q9HWD6;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=50S ribosomal protein L4;
GN Name=rplD; OrderedLocusNames=PA4262;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [2]
RP DOES NOT REGULATE THE E.COLI S10 OPERON.
RX PubMed=10498727; DOI=10.1128/jb.181.19.6124-6132.1999;
RA Allen T., Shen P., Samsel L., Liu R., Lindahl L., Zengel J.M.;
RT "Phylogenetic analysis of L4-mediated autogenous control of the S10
RT ribosomal protein operon.";
RL J. Bacteriol. 181:6124-6132(1999).
CC -!- FUNCTION: One of the primary rRNA binding proteins, this protein
CC initially binds near the 5'-end of the 23S rRNA. It is important during
CC the early stages of 50S assembly. It makes multiple contacts with
CC different domains of the 23S rRNA in the assembled 50S subunit and
CC ribosome (By similarity). {ECO:0000250}.
CC -!- FUNCTION: The P.aeruginosa S10 leader is not regulated by the E.coli L4
CC protein. This and other data strongly suggest the S10 operon is
CC regulated differently than in E.coli.
CC -!- FUNCTION: Forms part of the polypeptide exit tunnel. {ECO:0000250}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL4 family.
CC {ECO:0000305}.
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DR EMBL; AE004091; AAG07650.1; -; Genomic_DNA.
DR PIR; D83116; D83116.
DR RefSeq; NP_252952.1; NC_002516.2.
DR RefSeq; WP_003093737.1; NZ_QZGE01000028.1.
DR AlphaFoldDB; Q9HWD6; -.
DR SMR; Q9HWD6; -.
DR STRING; 287.DR97_3649; -.
DR PaxDb; Q9HWD6; -.
DR PRIDE; Q9HWD6; -.
DR DNASU; 881754; -.
DR EnsemblBacteria; AAG07650; AAG07650; PA4262.
DR GeneID; 881754; -.
DR KEGG; pae:PA4262; -.
DR PATRIC; fig|208964.12.peg.4463; -.
DR PseudoCAP; PA4262; -.
DR HOGENOM; CLU_041575_5_2_6; -.
DR InParanoid; Q9HWD6; -.
DR OMA; PQVHILE; -.
DR PhylomeDB; Q9HWD6; -.
DR BioCyc; PAER208964:G1FZ6-4335-MON; -.
DR PRO; PR:Q9HWD6; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1370.10; -; 1.
DR HAMAP; MF_01328_B; Ribosomal_L4_B; 1.
DR InterPro; IPR002136; Ribosomal_L4/L1e.
DR InterPro; IPR023574; Ribosomal_L4_dom_sf.
DR InterPro; IPR013005; Ribosomal_uL4/L1e.
DR PANTHER; PTHR10746; PTHR10746; 1.
DR Pfam; PF00573; Ribosomal_L4; 1.
DR SUPFAM; SSF52166; SSF52166; 1.
DR TIGRFAMs; TIGR03953; rplD_bact; 1.
PE 3: Inferred from homology;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding;
KW rRNA-binding.
FT CHAIN 1..200
FT /note="50S ribosomal protein L4"
FT /id="PRO_0000129259"
FT REGION 38..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 200 AA; 21640 MW; E285F29A5673D558 CRC64;
MQLNVNGAQA IEVSERTFGG EFNETLVHQA VVAYMAGGRQ GSKAQKTRSE VSGGGKKPWR
QKGTGRARAG TIRSPIWRGG GTTFAAKPRS HEQKLNKKMY RAALRSILAE LVRLDRLVVV
ADFAVDAPKT KGLVAKLDTL GLKDVLIVTD GVDENLYLAA RNLAHVDVRD VQGSDPVSLI
AYDKVLVTVS AVKKFEELLG