ID   RL4_SALTY               Reviewed;         201 AA.
AC   P60726; P02388;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=50S ribosomal protein L4;
GN   Name=rplD; OrderedLocusNames=STM3439;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   FUNCTION IN TRANSCRIPTIONAL/TRANSLATIONAL REGULATION OF THE S10 RIBOSOMAL
RP   PROTEIN OPERON.
RC   STRAIN=LT2;
RX   PubMed=10498727; DOI=10.1128/jb.181.19.6124-6132.1999;
RA   Allen T., Shen P., Samsel L., Liu R., Lindahl L., Zengel J.M.;
RT   "Phylogenetic analysis of L4-mediated autogenous control of the S10
RT   ribosomal protein operon.";
RL   J. Bacteriol. 181:6124-6132(1999).
CC   -!- FUNCTION: One of the primary rRNA binding proteins, this protein
CC       initially binds near the 5'-end of the 23S rRNA. It is important during
CC       the early stages of 50S assembly. It makes multiple contacts with
CC       different domains of the 23S rRNA in the assembled 50S subunit and
CC       ribosome (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Protein L4 is a both a transcriptional repressor and a
CC       translational repressor protein. It regulates transcription of the S10
CC       operon (to which L4 belongs) by causing premature termination of
CC       transcription within the S10 leader. L4 controls the translation of the
CC       S10 operon by binding to its mRNA. {ECO:0000269|PubMed:10498727}.
CC   -!- FUNCTION: Forms part of the polypeptide exit tunnel.
CC       {ECO:0000269|PubMed:10498727}.
CC   -!- SUBUNIT: Part of the 50S ribosomal subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL4 family.
CC       {ECO:0000305}.
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DR   EMBL; AE006468; AAL22302.1; -; Genomic_DNA.
DR   RefSeq; NP_462343.1; NC_003197.2.
DR   RefSeq; WP_000424395.1; NC_003197.2.
DR   AlphaFoldDB; P60726; -.
DR   SMR; P60726; -.
DR   STRING; 99287.STM3439; -.
DR   PaxDb; P60726; -.
DR   EnsemblBacteria; AAL22302; AAL22302; STM3439.
DR   GeneID; 1254962; -.
DR   GeneID; 67463983; -.
DR   KEGG; stm:STM3439; -.
DR   PATRIC; fig|99287.12.peg.3636; -.
DR   HOGENOM; CLU_041575_5_2_6; -.
DR   OMA; PQVHILE; -.
DR   PhylomeDB; P60726; -.
DR   BioCyc; SENT99287:STM3439-MON; -.
DR   PRO; PR:P60726; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-KW.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1370.10; -; 1.
DR   HAMAP; MF_01328_B; Ribosomal_L4_B; 1.
DR   InterPro; IPR002136; Ribosomal_L4/L1e.
DR   InterPro; IPR023574; Ribosomal_L4_dom_sf.
DR   InterPro; IPR013005; Ribosomal_uL4/L1e.
DR   PANTHER; PTHR10746; PTHR10746; 1.
DR   Pfam; PF00573; Ribosomal_L4; 1.
DR   SUPFAM; SSF52166; SSF52166; 1.
DR   TIGRFAMs; TIGR03953; rplD_bact; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Repressor; Ribonucleoprotein; Ribosomal protein;
KW   RNA-binding; rRNA-binding; Transcription; Transcription regulation;
KW   Transcription termination; Translation regulation.
FT   CHAIN           1..201
FT                   /note="50S ribosomal protein L4"
FT                   /id="PRO_0000129270"
FT   REGION          44..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   201 AA;  22087 MW;  3A953206B0F083B5 CRC64;
     MELVLKDAQS ALTVSETTFG RDFNEALVHQ VVVAYAAGAR QGTRAQKTRA EVTGSGKKPW
     RQKGTGRARS GSIKSPIWRS GGVTFAARPQ DHSQKVNKKM YRGALKSILS ELVRQDRLIV
     VEKFSVEAPK TKLLAQKLKD MALEDVLIIT GELDENLFLA ARNLHKVDVR DATGIDPVSL
     IAFDKVVMTA DAVKQVEEML A