RL4_STAA8
ID RL4_STAA8 Reviewed; 207 AA.
AC Q2FW07;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=50S ribosomal protein L4 {ECO:0000255|HAMAP-Rule:MF_01328};
GN Name=rplD {ECO:0000255|HAMAP-Rule:MF_01328};
GN OrderedLocusNames=SAOUHSC_02511;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
CC -!- FUNCTION: One of the primary rRNA binding proteins, this protein
CC initially binds near the 5'-end of the 23S rRNA. It is important during
CC the early stages of 50S assembly. It makes multiple contacts with
CC different domains of the 23S rRNA in the assembled 50S subunit and
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_01328}.
CC -!- FUNCTION: Forms part of the polypeptide exit tunnel.
CC {ECO:0000255|HAMAP-Rule:MF_01328}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC Rule:MF_01328}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL4 family.
CC {ECO:0000255|HAMAP-Rule:MF_01328}.
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DR EMBL; CP000253; ABD31529.1; -; Genomic_DNA.
DR RefSeq; WP_000024827.1; NZ_LS483365.1.
DR RefSeq; YP_500978.1; NC_007795.1.
DR PDB; 4WCE; X-ray; 3.53 A; C=1-207.
DR PDB; 4WF9; X-ray; 3.43 A; C=1-207.
DR PDB; 4WFA; X-ray; 3.39 A; C=1-207.
DR PDB; 4WFB; X-ray; 3.43 A; C=1-207.
DR PDB; 5HKV; X-ray; 3.66 A; C=1-207.
DR PDB; 5HL7; X-ray; 3.55 A; C=1-207.
DR PDB; 5LI0; EM; 3.80 A; F=3-201.
DR PDB; 5ND8; EM; 3.70 A; F=1-207.
DR PDB; 5ND9; EM; 3.70 A; F=1-207.
DR PDB; 5NRG; X-ray; 3.44 A; C=1-207.
DR PDB; 5TCU; EM; 3.90 A; LJ=3-207.
DR PDB; 6DDD; EM; 3.10 A; S=1-207.
DR PDB; 6DDG; EM; 3.10 A; S=1-207.
DR PDB; 6HMA; EM; 2.65 A; E=2-207.
DR PDB; 6SJ6; EM; 3.23 A; F=1-207.
DR PDB; 6WQN; EM; 2.90 A; S=1-207.
DR PDB; 6WQQ; EM; 3.10 A; S=1-207.
DR PDB; 6WRS; EM; 3.20 A; S=1-207.
DR PDB; 6WRU; EM; 3.10 A; S=1-207.
DR PDB; 6YEF; EM; 3.20 A; F=1-207.
DR PDB; 7NHL; EM; 3.10 A; I=1-207.
DR PDB; 7NHM; EM; 3.10 A; I=1-207.
DR PDBsum; 4WCE; -.
DR PDBsum; 4WF9; -.
DR PDBsum; 4WFA; -.
DR PDBsum; 4WFB; -.
DR PDBsum; 5HKV; -.
DR PDBsum; 5HL7; -.
DR PDBsum; 5LI0; -.
DR PDBsum; 5ND8; -.
DR PDBsum; 5ND9; -.
DR PDBsum; 5NRG; -.
DR PDBsum; 5TCU; -.
DR PDBsum; 6DDD; -.
DR PDBsum; 6DDG; -.
DR PDBsum; 6HMA; -.
DR PDBsum; 6SJ6; -.
DR PDBsum; 6WQN; -.
DR PDBsum; 6WQQ; -.
DR PDBsum; 6WRS; -.
DR PDBsum; 6WRU; -.
DR PDBsum; 6YEF; -.
DR PDBsum; 7NHL; -.
DR PDBsum; 7NHM; -.
DR AlphaFoldDB; Q2FW07; -.
DR SMR; Q2FW07; -.
DR IntAct; Q2FW07; 2.
DR STRING; 1280.SAXN108_2498; -.
DR EnsemblBacteria; ABD31529; ABD31529; SAOUHSC_02511.
DR GeneID; 3920887; -.
DR KEGG; sao:SAOUHSC_02511; -.
DR PATRIC; fig|93061.5.peg.2266; -.
DR eggNOG; COG0088; Bacteria.
DR HOGENOM; CLU_041575_5_2_9; -.
DR OMA; PQVHILE; -.
DR PRO; PR:Q2FW07; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1370.10; -; 1.
DR HAMAP; MF_01328_B; Ribosomal_L4_B; 1.
DR InterPro; IPR002136; Ribosomal_L4/L1e.
DR InterPro; IPR023574; Ribosomal_L4_dom_sf.
DR InterPro; IPR013005; Ribosomal_uL4/L1e.
DR PANTHER; PTHR10746; PTHR10746; 1.
DR Pfam; PF00573; Ribosomal_L4; 1.
DR SUPFAM; SSF52166; SSF52166; 1.
DR TIGRFAMs; TIGR03953; rplD_bact; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW RNA-binding; rRNA-binding.
FT CHAIN 1..207
FT /note="50S ribosomal protein L4"
FT /id="PRO_1000052508"
FT REGION 50..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 3..7
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 9..11
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 13..18
FT /evidence="ECO:0007829|PDB:6HMA"
FT TURN 21..23
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 24..26
FT /evidence="ECO:0007829|PDB:6HMA"
FT HELIX 30..43
FT /evidence="ECO:0007829|PDB:6HMA"
FT TURN 54..56
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 57..59
FT /evidence="ECO:0007829|PDB:6DDD"
FT STRAND 67..72
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 78..80
FT /evidence="ECO:0007829|PDB:6WRU"
FT STRAND 83..85
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 88..90
FT /evidence="ECO:0007829|PDB:4WFB"
FT HELIX 103..118
FT /evidence="ECO:0007829|PDB:6HMA"
FT TURN 119..121
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 123..126
FT /evidence="ECO:0007829|PDB:6HMA"
FT HELIX 136..145
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 146..148
FT /evidence="ECO:0007829|PDB:4WF9"
FT STRAND 150..158
FT /evidence="ECO:0007829|PDB:6HMA"
FT HELIX 161..166
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 168..170
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 173..177
FT /evidence="ECO:0007829|PDB:6HMA"
FT HELIX 178..180
FT /evidence="ECO:0007829|PDB:6HMA"
FT HELIX 183..188
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 190..194
FT /evidence="ECO:0007829|PDB:6HMA"
FT HELIX 196..205
FT /evidence="ECO:0007829|PDB:6HMA"
SQ SEQUENCE 207 AA; 22465 MW; 43A13417F457C6CC CRC64;
MANYDVLKLD GTKSGSIELS DAVFGIEPNN SVLFEAINLQ RASLRQGTHA VKNRSAVSGG
GRKPWKQKGT GRARQGTIRA PQWRGGGIVF GPTPRSYAYK MPKKMRRLAL RSALSFKAQE
NGLTVVDAFN FEAPKTKEFK NVLSTLEQPK KVLVVTENED VNVELSARNI PGVQVTTAQG
LNVLDITNAD SLVITEAAAK KVEEVLG
