ID   RL4_TETTS               Reviewed;         410 AA.
AC   P0DJ55;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=60S ribosomal protein L4;
GN   Name=RPL4; ORFNames=TTHERM_00333210;
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210;
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (3.52 ANGSTROMS) OF 60S RIBOSOME.
RX   PubMed=22052974; DOI=10.1126/science.1211204;
RA   Klinge S., Voigts-Hoffmann F., Leibundgut M., Arpagaus S., Ban N.;
RT   "Crystal structure of the eukaryotic 60S ribosomal subunit in complex with
RT   initiation factor 6.";
RL   Science 334:941-948(2011).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL4 family.
CC       {ECO:0000305}.
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DR   EMBL; GG662666; EAR97243.2; -; Genomic_DNA.
DR   RefSeq; XP_001017488.2; XM_001017488.3.
DR   PDB; 4V8P; X-ray; 3.52 A; BC/CC/EC/GC=1-410.
DR   PDBsum; 4V8P; -.
DR   AlphaFoldDB; P0DJ55; -.
DR   SMR; P0DJ55; -.
DR   IntAct; P0DJ55; 1.
DR   STRING; 5911.EAR97243; -.
DR   EnsemblProtists; EAR97243; EAR97243; TTHERM_00333210.
DR   GeneID; 7828093; -.
DR   KEGG; tet:TTHERM_00333210; -.
DR   eggNOG; KOG1475; Eukaryota.
DR   HOGENOM; CLU_026535_4_0_1; -.
DR   InParanoid; P0DJ55; -.
DR   OMA; PCIICNE; -.
DR   OrthoDB; 878848at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   Gene3D; 3.40.1370.10; -; 1.
DR   InterPro; IPR025755; Ribos_L4_C_dom.
DR   InterPro; IPR002136; Ribosomal_L4/L1e.
DR   InterPro; IPR013000; Ribosomal_L4/L1e_euk/arc_CS.
DR   InterPro; IPR023574; Ribosomal_L4_dom_sf.
DR   InterPro; IPR045240; Ribosomal_L4_euk/arch.
DR   PANTHER; PTHR19431; PTHR19431; 1.
DR   Pfam; PF14374; Ribos_L4_asso_C; 1.
DR   Pfam; PF00573; Ribosomal_L4; 1.
DR   SUPFAM; SSF52166; SSF52166; 1.
DR   PROSITE; PS00939; RIBOSOMAL_L1E; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein.
FT   CHAIN           1..410
FT                   /note="60S ribosomal protein L4"
FT                   /id="PRO_0000413490"
SQ   SEQUENCE   410 AA;  45107 MW;  E8BF0AECD50F6D6C CRC64;
     MTSRPQIHVH DAKEANKQTA TKLTLPAVFT APIRTDIVHK VFTDLNKNRK QASGVKISTR
     GTAGMGHSAE SWGTGRAVAR IPRVGGSGTH RSGQAAFGNQ CRKGRMFAPL KTYRRVHRRV
     NVNQKRHAVA AALAASALVP LVFARGHRIS NVQELPYVFD DSVESYEKTK QAVAFLKRVG
     AYDDVLRVAE TKALRAGQGK LRNRRYKLRR GPLVVYGNEK STLTRALRNI PGVDVCNVNR
     LNLLQLAPGG HVGRFIIWTE SAFKKLNEIF GTYSTTGVQK SGYQLQRPLL ANADIARIIN
     SNEVQSVVKV AGTTETHERK KNPLTNNNAL FKLNPAAKIV KEQAKKAAEA SKAKRQATLK
     ANRKAAKTHK KGSQAWIAAF NKANEEAIAK ARQEDADFIA QGQEIKEGDE