RL4_VIBCH
ID RL4_VIBCH Reviewed; 200 AA.
AC Q9KNY5;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=50S ribosomal protein L4;
GN Name=rplD; OrderedLocusNames=VC_2595;
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
RN [2]
RP CAN REGULATE THE E.COLI S10 OPERON.
RX PubMed=10498727; DOI=10.1128/jb.181.19.6124-6132.1999;
RA Allen T., Shen P., Samsel L., Liu R., Lindahl L., Zengel J.M.;
RT "Phylogenetic analysis of L4-mediated autogenous control of the S10
RT ribosomal protein operon.";
RL J. Bacteriol. 181:6124-6132(1999).
CC -!- FUNCTION: One of the primary rRNA binding proteins, this protein
CC initially binds near the 5'-end of the 23S rRNA. It is important during
CC the early stages of 50S assembly. It makes multiple contacts with
CC different domains of the 23S rRNA in the assembled 50S subunit and
CC ribosome (By similarity). {ECO:0000250}.
CC -!- FUNCTION: Protein L4 is a both a transcriptional repressor and a
CC translational repressor protein. It regulates transcription of the S10
CC operon (to which L4 belongs) by causing premature termination of
CC transcription within the S10 leader. L4 controls the translation of the
CC S10 operon by binding to its mRNA (By similarity). {ECO:0000250}.
CC -!- FUNCTION: As the V.cholerae S10 leader can be regulated in vitro by the
CC E.coli L4 protein this suggests the endogenous protein controls its own
CC S10 operon in a similar fashion.
CC -!- FUNCTION: Forms part of the polypeptide exit tunnel. {ECO:0000250}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL4 family.
CC {ECO:0000305}.
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DR EMBL; AE003852; AAF95736.1; -; Genomic_DNA.
DR PIR; E82059; E82059.
DR RefSeq; NP_232223.1; NC_002505.1.
DR RefSeq; WP_000422344.1; NZ_LT906614.1.
DR AlphaFoldDB; Q9KNY5; -.
DR SMR; Q9KNY5; -.
DR STRING; 243277.VC_2595; -.
DR DNASU; 2615612; -.
DR EnsemblBacteria; AAF95736; AAF95736; VC_2595.
DR GeneID; 57990982; -.
DR GeneID; 66938519; -.
DR KEGG; vch:VC_2595; -.
DR PATRIC; fig|243277.26.peg.2474; -.
DR eggNOG; COG0088; Bacteria.
DR HOGENOM; CLU_041575_5_2_6; -.
DR OMA; PQVHILE; -.
DR BioCyc; VCHO:VC2595-MON; -.
DR Proteomes; UP000000584; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1370.10; -; 1.
DR HAMAP; MF_01328_B; Ribosomal_L4_B; 1.
DR InterPro; IPR002136; Ribosomal_L4/L1e.
DR InterPro; IPR023574; Ribosomal_L4_dom_sf.
DR InterPro; IPR013005; Ribosomal_uL4/L1e.
DR PANTHER; PTHR10746; PTHR10746; 1.
DR Pfam; PF00573; Ribosomal_L4; 1.
DR SUPFAM; SSF52166; SSF52166; 1.
DR TIGRFAMs; TIGR03953; rplD_bact; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repressor; Ribonucleoprotein; Ribosomal protein;
KW RNA-binding; rRNA-binding; Transcription; Transcription regulation;
KW Transcription termination; Translation regulation.
FT CHAIN 1..200
FT /note="50S ribosomal protein L4"
FT /id="PRO_0000129308"
FT REGION 42..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 200 AA; 21868 MW; 33566D2E0D9193D8 CRC64;
MELMVKGANA LTVSETTFGR EFNEALVHQV VVAYAAGARQ GTRAQKTRSE VSGGGAKPWR
QKGTGRARAG TIRSPIWRTG GVTFAAKPQD HSQKVNKKMY RGAMKSILSE LVRQERLIVV
ENFSVEAPKT KALVAKLKEL ELNDVLIVTG EVDENLFLAA RNLYKVDVRD VTGIDPVSLI
AFDKVLMTAA AVKQVEEMLA
