ID   RL4_YERPS               Reviewed;         201 AA.
AC   P60731; P11253; Q664S2;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=50S ribosomal protein L4;
GN   Name=rplD; Synonyms=eryA; OrderedLocusNames=YPTB3697;
OS   Yersinia pseudotuberculosis serotype I (strain IP32953).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=273123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2657663; DOI=10.1093/nar/17.9.3601;
RA   Gross U., Chen J.H., Kono D.H., Lobo J.G., Yu D.T.Y.;
RT   "High degree of conservation between ribosomal proteins of Yersinia
RT   pseudotuberculosis and Escherichia coli.";
RL   Nucleic Acids Res. 17:3601-3602(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP32953;
RX   PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA   Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA   Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA   Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA   Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA   Derbise A., Hauser L.J., Garcia E.;
RT   "Insights into the evolution of Yersinia pestis through whole-genome
RT   comparison with Yersinia pseudotuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
RN   [3]
RP   ABILITY TO REPRESS THE E.COLI S10 OPERON.
RX   PubMed=8722027; DOI=10.1139/o95-119;
RA   Zengel J.M., Vorozheikina D., Li X., Lindahl L.;
RT   "Regulation of the Escherichia coli S10 ribosomal protein operon by
RT   heterologous L4 ribosomal proteins.";
RL   Biochem. Cell Biol. 73:1105-1112(1995).
CC   -!- FUNCTION: One of the primary rRNA binding proteins, this protein
CC       initially binds near the 5'-end of the 23S rRNA. It is important during
CC       the early stages of 50S assembly. It makes multiple contacts with
CC       different domains of the 23S rRNA in the assembled 50S subunit and
CC       ribosome (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Protein L4 is a both a transcriptional repressor and a
CC       translational repressor protein. It regulates transcription of the S10
CC       operon (to which L4 belongs) by causing premature termination of
CC       transcription within the S10 leader. L4 controls the translation of the
CC       S10 operon by binding to its mRNA (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: This protein when expressed in E.coli represses both
CC       transcription and translation of the endogenous S10 operon.
CC   -!- FUNCTION: Forms part of the polypeptide exit tunnel. {ECO:0000250}.
CC   -!- SUBUNIT: Part of the 50S ribosomal subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL4 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH22935.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X14363; CAA32543.1; -; Genomic_DNA.
DR   EMBL; BX936398; CAH22935.1; ALT_INIT; Genomic_DNA.
DR   PIR; S04141; R5EB4Y.
DR   RefSeq; WP_002218934.1; NZ_CP009712.1.
DR   AlphaFoldDB; P60731; -.
DR   SMR; P60731; -.
DR   EnsemblBacteria; CAH22935; CAH22935; YPTB3697.
DR   GeneID; 66843879; -.
DR   KEGG; ypo:BZ17_2890; -.
DR   KEGG; yps:YPTB3697; -.
DR   PATRIC; fig|273123.14.peg.3031; -.
DR   OMA; PQVHILE; -.
DR   Proteomes; UP000001011; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-KW.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1370.10; -; 1.
DR   HAMAP; MF_01328_B; Ribosomal_L4_B; 1.
DR   InterPro; IPR002136; Ribosomal_L4/L1e.
DR   InterPro; IPR023574; Ribosomal_L4_dom_sf.
DR   InterPro; IPR013005; Ribosomal_uL4/L1e.
DR   PANTHER; PTHR10746; PTHR10746; 1.
DR   Pfam; PF00573; Ribosomal_L4; 1.
DR   SUPFAM; SSF52166; SSF52166; 1.
DR   TIGRFAMs; TIGR03953; rplD_bact; 1.
PE   3: Inferred from homology;
KW   Repressor; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding;
KW   Transcription; Transcription regulation; Transcription termination;
KW   Translation regulation.
FT   CHAIN           1..201
FT                   /note="50S ribosomal protein L4"
FT                   /id="PRO_0000129320"
FT   REGION          45..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   201 AA;  22010 MW;  887B1EB220B263C1 CRC64;
     MELVMKDAPG ALTVSETTFG RDFNEALVHQ VVVAYAAGAR QGTRAQKTRA EVTGSGKKPW
     RQKGTGRARA GSVKSPIWRS GGVTFAAKPQ DHSQKVNKKM YRGALKSILS ELVRQDRLII
     VEKFSVEAPK TKLLAQKLKD MALEDVLIVT GELDENLFLA ARNLYKVDVR DVAGIDPVSL
     IAFDKVVMTA DAVKQVEEML A