ID   RL52_ARATH              Reviewed;         301 AA.
AC   P49227; Q41921;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2001, sequence version 3.
DT   25-MAY-2022, entry version 139.
DE   RecName: Full=60S ribosomal protein L5-2 {ECO:0000303|PubMed:11598216};
DE            Short=Ribosomal protein L5 B {ECO:0000303|PubMed:11598216};
DE   AltName: Full=Protein OLIGOCELLULA 7 {ECO:0000303|PubMed:19392710};
GN   Name=RPL5B {ECO:0000303|PubMed:11598216};
GN   Synonyms=OLI7 {ECO:0000303|PubMed:19392710};
GN   OrderedLocusNames=At5g39740 {ECO:0000312|Araport:AT5G39740};
GN   ORFNames=MKM21.30 {ECO:0000312|EMBL:BAB11380.1},
GN   MKM21.5 {ECO:0000312|EMBL:BAB11380.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA   Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT   features of the regions of 1,013,767 bp covered by sixteen physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:297-308(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-60 AND 217-301.
RC   STRAIN=cv. Columbia; TISSUE=Green siliques;
RX   PubMed=8281187; DOI=10.1046/j.1365-313x.1993.04061051.x;
RA   Hoefte H., Desprez T., Amselem J., Chiapello H., Rouze P., Caboche M.,
RA   Moisan A., Jourjon M.-F., Charpenteau J.-L., Berthomieu P., Guerrier D.,
RA   Giraudat J., Quigley F., Thomas F., Yu D.-Y., Mache R., Raynal M.,
RA   Cooke R., Grellet F., Delseny M., Parmentier Y., de Marcillac G., Gigot C.,
RA   Fleck J., Philipps G., Axelos M., Bardet C., Tremousaygue D., Lescure B.;
RT   "An inventory of 1152 expressed sequence tags obtained by partial
RT   sequencing of cDNAs from Arabidopsis thaliana.";
RL   Plant J. 4:1051-1061(1993).
RN   [5]
RP   GENE FAMILY ORGANIZATION, AND NOMENCLATURE.
RX   PubMed=11598216; DOI=10.1104/pp.010265;
RA   Barakat A., Szick-Miranda K., Chang I.-F., Guyot R., Blanc G., Cooke R.,
RA   Delseny M., Bailey-Serres J.;
RT   "The organization of cytoplasmic ribosomal protein genes in the Arabidopsis
RT   genome.";
RL   Plant Physiol. 127:398-415(2001).
RN   [6]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=cv. Columbia;
RX   PubMed=18305007; DOI=10.1242/dev.017913;
RA   Yao Y., Ling Q., Wang H., Huang H.;
RT   "Ribosomal proteins promote leaf adaxial identity.";
RL   Development 135:1325-1334(2008).
RN   [7]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=19392710; DOI=10.1111/j.1365-313x.2009.03886.x;
RA   Fujikura U., Horiguchi G., Ponce M.R., Micol J.L., Tsukaya H.;
RT   "Coordination of cell proliferation and cell expansion mediated by
RT   ribosome-related processes in the leaves of Arabidopsis thaliana.";
RL   Plant J. 59:499-508(2009).
CC   -!- FUNCTION: Component of the ribosome, a large ribonucleoprotein complex
CC       responsible for the synthesis of proteins in the cell. The small
CC       ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the
CC       encoded message by selecting cognate aminoacyl-transfer RNA (tRNA)
CC       molecules. The large subunit (LSU) contains the ribosomal catalytic
CC       site termed the peptidyl transferase center (PTC), which catalyzes the
CC       formation of peptide bonds, thereby polymerizing the amino acids
CC       delivered by tRNAs into a polypeptide chain. The nascent polypeptides
CC       leave the ribosome through a tunnel in the LSU and interact with
CC       protein factors that function in enzymatic processing, targeting, and
CC       the membrane insertion of nascent chains at the exit of the ribosomal
CC       tunnel. Seems involved in the regulation of cell proliferation
CC       (PubMed:19392710). Essential in leaf polarity establishment, probably
CC       having a role for translation in leaf dorsoventral patterning to
CC       specify leaf adaxial identity (PubMed:18305007).
CC       {ECO:0000250|UniProtKB:P26321, ECO:0000269|PubMed:18305007,
CC       ECO:0000269|PubMed:19392710}.
CC   -!- SUBUNIT: Component of the large ribosomal subunit (LSU).
CC       {ECO:0000250|UniProtKB:P26321}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8LBI1}. Nucleus
CC       {ECO:0000250|UniProtKB:Q8LBI1}. Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q8LBI1}. Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q8LBI1}.
CC   -!- DISRUPTION PHENOTYPE: Moderate reduction in cell number
CC       (PubMed:19392710). Abnormal leaf patterning, with the abaxial mesophyll
CC       features appearing in the adaxial mesophyll domain (PubMed:18305007).
CC       Double mutants oli2 oli7 have further reduced cell number but exhibit
CC       also excessive postmitotic cell enlargement in leaves (compensation
CC       phenotype) (PubMed:19392710). Plant missing both OLI7 and GIF1/AN3 have
CC       a strong compensation phenotype (PubMed:19392710).
CC       {ECO:0000269|PubMed:18305007, ECO:0000269|PubMed:19392710}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL18 family.
CC       {ECO:0000305}.
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DR   EMBL; AB016876; BAB11380.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED94469.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED94470.1; -; Genomic_DNA.
DR   EMBL; AY079020; AAL84975.1; -; mRNA.
DR   EMBL; AY093123; AAM13122.1; -; mRNA.
DR   EMBL; BT008706; AAP42719.1; -; mRNA.
DR   EMBL; Z17696; CAA79040.1; -; mRNA.
DR   EMBL; Z17697; CAA79041.1; -; mRNA.
DR   RefSeq; NP_001190439.1; NM_001203510.1.
DR   RefSeq; NP_198790.1; NM_123336.6.
DR   AlphaFoldDB; P49227; -.
DR   SMR; P49227; -.
DR   BioGRID; 19221; 103.
DR   STRING; 3702.AT5G39740.2; -.
DR   iPTMnet; P49227; -.
DR   PaxDb; P49227; -.
DR   PRIDE; P49227; -.
DR   ProteomicsDB; 236507; -.
DR   EnsemblPlants; AT5G39740.1; AT5G39740.1; AT5G39740.
DR   EnsemblPlants; AT5G39740.2; AT5G39740.2; AT5G39740.
DR   GeneID; 833970; -.
DR   Gramene; AT5G39740.1; AT5G39740.1; AT5G39740.
DR   Gramene; AT5G39740.2; AT5G39740.2; AT5G39740.
DR   KEGG; ath:AT5G39740; -.
DR   Araport; AT5G39740; -.
DR   TAIR; locus:2167042; AT5G39740.
DR   eggNOG; KOG0875; Eukaryota.
DR   HOGENOM; CLU_056222_1_0_1; -.
DR   InParanoid; P49227; -.
DR   OMA; KSQFQGY; -.
DR   OrthoDB; 999609at2759; -.
DR   PhylomeDB; P49227; -.
DR   PRO; PR:P49227; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; P49227; baseline and differential.
DR   Genevisible; P49227; AT.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; HDA:TAIR.
DR   GO; GO:0022626; C:cytosolic ribosome; HDA:TAIR.
DR   GO; GO:0005730; C:nucleolus; HDA:TAIR.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR   GO; GO:0009536; C:plastid; HDA:TAIR.
DR   GO; GO:0008097; F:5S rRNA binding; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR   GO; GO:0003735; F:structural constituent of ribosome; IDA:CAFA.
DR   GO; GO:0009955; P:adaxial/abaxial pattern specification; IMP:UniProtKB.
DR   GO; GO:0051301; P:cell division; IMP:TAIR.
DR   GO; GO:0009965; P:leaf morphogenesis; IMP:UniProtKB.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   HAMAP; MF_01337_A; Ribosomal_L18_A; 1.
DR   InterPro; IPR005485; Rbsml_L5_euk/L18_arc.
DR   InterPro; IPR025607; Rbsml_L5e_C.
DR   PANTHER; PTHR23410; PTHR23410; 1.
DR   Pfam; PF14204; Ribosomal_L18_c; 1.
DR   Pfam; PF17144; Ribosomal_L5e; 1.
DR   PRINTS; PR00058; RIBOSOMALL5.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein; RNA-binding; rRNA-binding.
FT   CHAIN           1..301
FT                   /note="60S ribosomal protein L5-2"
FT                   /id="PRO_0000131444"
FT   REGION          247..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        228
FT                   /note="K -> E (in Ref. 4; CAA79041)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   301 AA;  34437 MW;  FD9E945A969F9FB6 CRC64;
     MVFVKSSKSN AYFKRYQVKF RRRRDGKTDY RARIRLINQD KNKYNTPKYR FVVRFTNKDI
     VAQIVSASIA GDIVKASAYA HELPQYGLTV GLTNYAAAYC TGLLLARRVL KMLEMDDEYE
     GNVEATGEDF SVEPTDSRRP FRALLDVGLI RTTTGNRVFG ALKGALDGGL DIPHSDKRFA
     GFHKENKQLD AEIHRNYIYG GHVSNYMKLL GEDEPEKLQT HFSAYIKKGV EAESIEEMYK
     KVHAAIRAEP NHKKTEKSAP KEHKRYNLKK LTYEERKNKL IERVKALNGA GGDDDDEDDE
     E