ID   RL5_CAEEL               Reviewed;         293 AA.
AC   P49405;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=60S ribosomal protein L5;
GN   Name=rpl-5; ORFNames=F54C9.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Component of the ribosome, a large ribonucleoprotein complex
CC       responsible for the synthesis of proteins in the cell. The small
CC       ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the
CC       encoded message by selecting cognate aminoacyl-transfer RNA (tRNA)
CC       molecules. The large subunit (LSU) contains the ribosomal catalytic
CC       site termed the peptidyl transferase center (PTC), which catalyzes the
CC       formation of peptide bonds, thereby polymerizing the amino acids
CC       delivered by tRNAs into a polypeptide chain. The nascent polypeptides
CC       leave the ribosome through a tunnel in the LSU and interact with
CC       protein factors that function in enzymatic processing, targeting, and
CC       the membrane insertion of nascent chains at the exit of the ribosomal
CC       tunnel. {ECO:0000250|UniProtKB:P26321}.
CC   -!- SUBUNIT: Component of the large ribosomal subunit (LSU).
CC       {ECO:0000250|UniProtKB:P26321}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P26321}. Nucleus
CC       {ECO:0000250|UniProtKB:P26321}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL18 family.
CC       {ECO:0000305}.
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DR   EMBL; Z49967; CAA90251.1; -; Genomic_DNA.
DR   PIR; T22631; T22631.
DR   RefSeq; NP_495811.1; NM_063410.4.
DR   AlphaFoldDB; P49405; -.
DR   SMR; P49405; -.
DR   BioGRID; 39699; 94.
DR   DIP; DIP-24622N; -.
DR   IntAct; P49405; 1.
DR   STRING; 6239.F54C9.5; -.
DR   iPTMnet; P49405; -.
DR   EPD; P49405; -.
DR   PaxDb; P49405; -.
DR   PeptideAtlas; P49405; -.
DR   EnsemblMetazoa; F54C9.5.1; F54C9.5.1; WBGene00004416.
DR   GeneID; 174371; -.
DR   KEGG; cel:CELE_F54C9.5; -.
DR   UCSC; F54C9.5.1; c. elegans.
DR   CTD; 174371; -.
DR   WormBase; F54C9.5; CE02255; WBGene00004416; rpl-5.
DR   eggNOG; KOG0875; Eukaryota.
DR   GeneTree; ENSGT00950000183210; -.
DR   HOGENOM; CLU_056222_1_0_1; -.
DR   InParanoid; P49405; -.
DR   OMA; KSQFQGY; -.
DR   OrthoDB; 999609at2759; -.
DR   PhylomeDB; P49405; -.
DR   Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-CEL-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-CEL-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-CEL-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-CEL-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:P49405; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00004416; Expressed in larva and 4 other tissues.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008097; F:5S rRNA binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   HAMAP; MF_01337_A; Ribosomal_L18_A; 1.
DR   InterPro; IPR005485; Rbsml_L5_euk/L18_arc.
DR   InterPro; IPR025607; Rbsml_L5e_C.
DR   PANTHER; PTHR23410; PTHR23410; 1.
DR   Pfam; PF14204; Ribosomal_L18_c; 1.
DR   Pfam; PF17144; Ribosomal_L5e; 1.
DR   PRINTS; PR00058; RIBOSOMALL5.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein; RNA-binding; rRNA-binding.
FT   CHAIN           1..293
FT                   /note="60S ribosomal protein L5"
FT                   /id="PRO_0000131443"
FT   REGION          249..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   293 AA;  33386 MW;  F55F3D333BA6D3FB CRC64;
     MGLVKVIKNK AYFKRYQVKL RRRREGKTDY YARKRLTVQD KNKYNTPKYR LIVRITNKDV
     VAQLAYSKIE GDVVVASAYS HELPRYGLKV GLTNYAAAYA TGLLLARRHL KTIGLDSTYK
     GHEELTGEDY NVEEEGDRAP FKAVLDIGLA RTTTGSKIFA VMKGVADGGI NVPHSESRFF
     GFDQESKEYN AEAHRDRILG KHVADYMTYL KEEDEDRYKR QFSKFLAAGL NADNLVATYQ
     KVHSAIRADA SPAAKKAAKP SKRHTAKRLT YDERKQRVAD KKALLLQLKE QQE