ID   AAXA_CHLPN              Reviewed;         438 AA.
AC   Q9Z6M6; Q7AHX0; Q7DE86; Q7VPQ6;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=Porin AaxA;
DE   AltName: Full=Outer membrane protein AaxA;
DE   Flags: Precursor;
GN   Name=aaxA; OrderedLocusNames=CPn_1033, CP_0819, CPj1033, CpB1073;
OS   Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=83558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CWL029;
RX   PubMed=10192388; DOI=10.1038/7716;
RA   Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA   Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT   "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL   Nat. Genet. 21:385-389(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR39;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J138;
RX   PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA   Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA   Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT   "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT   Japan and CWL029 from USA.";
RL   Nucleic Acids Res. 28:2311-2314(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW-183;
RA   Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA   Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT   "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT   other Chlamydia strains based on whole genome sequence analysis.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   FUNCTION IN ARGININE UPTAKE, AND SUBCELLULAR LOCATION.
RC   STRAIN=Kajaani 6;
RX   PubMed=18790867; DOI=10.1128/jb.00652-08;
RA   Smith C.B., Graham D.E.;
RT   "Outer and inner membrane proteins compose an arginine-agmatine exchange
RT   system in Chlamydophila pneumoniae.";
RL   J. Bacteriol. 190:7431-7440(2008).
CC   -!- FUNCTION: Facilitates L-arginine uptake, as part of the AaxABC system.
CC       The arginine uptake by the bacterium in the macrophage may be a
CC       virulence factor against the host innate immune response.
CC       {ECO:0000269|PubMed:18790867}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000269|PubMed:18790867}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:18790867}.
CC   -!- MISCELLANEOUS: Functions optimally at a neutral or moderately acidic
CC       pH.
CC   -!- SIMILARITY: Belongs to the OprB family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAP99002.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE001363; AAD19170.1; -; Genomic_DNA.
DR   EMBL; AE002161; AAF38614.1; -; Genomic_DNA.
DR   EMBL; BA000008; BAA99240.1; -; Genomic_DNA.
DR   EMBL; AE009440; AAP99002.1; ALT_INIT; Genomic_DNA.
DR   PIR; C72006; C72006.
DR   PIR; F86619; F86619.
DR   RefSeq; NP_225227.1; NC_000922.1.
DR   RefSeq; WP_010883666.1; NZ_LN847257.1.
DR   AlphaFoldDB; Q9Z6M6; -.
DR   SMR; Q9Z6M6; -.
DR   STRING; 115711.CP_0819; -.
DR   TCDB; 1.B.23.1.11; the cyanobacterial porin (cbp) family.
DR   EnsemblBacteria; AAD19170; AAD19170; CPn_1033.
DR   EnsemblBacteria; AAF38614; AAF38614; CP_0819.
DR   KEGG; cpa:CP_0819; -.
DR   KEGG; cpj:CPj1033; -.
DR   KEGG; cpn:CPn_1033; -.
DR   KEGG; cpt:CpB1073; -.
DR   PATRIC; fig|115713.3.peg.1131; -.
DR   eggNOG; COG3659; Bacteria.
DR   HOGENOM; CLU_619231_0_0_0; -.
DR   OrthoDB; 338964at2; -.
DR   Proteomes; UP000000583; Chromosome.
DR   Proteomes; UP000000801; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.160.180; -; 1.
DR   InterPro; IPR007049; Carb-sel_porin_OprB.
DR   InterPro; IPR038673; OprB_sf.
DR   Pfam; PF04966; OprB; 1.
PE   1: Evidence at protein level;
KW   Amino-acid transport; Cell outer membrane; Ion transport; Membrane; Porin;
KW   Signal; Transmembrane; Transmembrane beta strand; Transport; Virulence.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..438
FT                   /note="Porin AaxA"
FT                   /id="PRO_0000363179"
SQ   SEQUENCE   438 AA;  48843 MW;  E1454022C3A20717 CRC64;
     MISFRFLLLS GLCALGISSY AETPKETTGH YHRYKARIQK KHPESIKESA PSETPHHNSL
     LSPVTNIFCS HPWKDGISVS NLLTSVEKAT NTQISLDFSI LPQWFYPHKA LGQTQALEIP
     SWQFYFSPST TWTLYDSPTA GQGIVDFSYT LIHYWQTNGV DANQAAGTAS SMNDYSNREN
     NLAQLTFSQT FPGDFLTLAI GQYSLYAIDG TLYDNDQYSG FISYALSQNA SATYSLGSTG
     AYLQFTPNSE IKVQLGFQDS YNIDGTNFSI YNLTKSKYNF YGYASWTPKP SCGDGQYSVL
     LYSTRKVPEQ NSQVTGWSLN AAQHIHEKLY LFGRINGATG TALPINRSYV LGLVSENPLN
     RHSQDLLGIG FATNKVNAKA ISNVNKLRRY ESVMEAFATI GFGPYISLTP DFQLYIHPAL
     RPERRTSQVY GLRANLSL