RL5_PYRFU
ID RL5_PYRFU Reviewed; 186 AA.
AC Q8U012;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=50S ribosomal protein L5 {ECO:0000255|HAMAP-Rule:MF_01333};
DE AltName: Full=Large ribosomal subunit protein uL5;
GN Name=rpl5 {ECO:0000255|HAMAP-Rule:MF_01333}; OrderedLocusNames=PF1811;
OS Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=186497;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA DiRuggiero J., Robb F.T.;
RT "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT horikoshii inferred from complete genomic sequences.";
RL Genetics 152:1299-1305(1999).
RN [2] {ECO:0007744|PDB:4V6U}
RP STRUCTURE BY ELECTRON MICROSCOPY (6.60 ANGSTROMS) IN THE 70S RIBOSOME, AND
RP SUBUNIT.
RX PubMed=23222135; DOI=10.1093/nar/gks1259;
RA Armache J.P., Anger A.M., Marquez V., Franckenberg S., Frohlich T.,
RA Villa E., Berninghausen O., Thomm M., Arnold G.J., Beckmann R.,
RA Wilson D.N.;
RT "Promiscuous behaviour of archaeal ribosomal proteins: implications for
RT eukaryotic ribosome evolution.";
RL Nucleic Acids Res. 41:1284-1293(2013).
CC -!- FUNCTION: This is 1 of the proteins that binds and probably mediates
CC the attachment of the 5S RNA into the large ribosomal subunit, where it
CC forms part of the central protuberance. In the 70S ribosome it contacts
CC protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits;
CC this bridge is implicated in subunit movement. May contact the P site
CC tRNA; the 5S rRNA and some of its associated proteins might help
CC stabilize positioning of ribosome-bound tRNAs. {ECO:0000255|HAMAP-
CC Rule:MF_01333}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit (PubMed:23222135); contacts
CC the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the
CC 70S ribosome. {ECO:0000255|HAMAP-Rule:MF_01333,
CC ECO:0000269|PubMed:23222135}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL5 family.
CC {ECO:0000255|HAMAP-Rule:MF_01333}.
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DR EMBL; AE009950; AAL81935.1; -; Genomic_DNA.
DR RefSeq; WP_011012952.1; NZ_CP023154.1.
DR PDB; 4V4N; EM; 9.00 A; E=1-186.
DR PDB; 4V6U; EM; 6.60 A; BE=1-186.
DR PDBsum; 4V4N; -.
DR PDBsum; 4V6U; -.
DR AlphaFoldDB; Q8U012; -.
DR SMR; Q8U012; -.
DR STRING; 186497.PF1811; -.
DR PRIDE; Q8U012; -.
DR EnsemblBacteria; AAL81935; AAL81935; PF1811.
DR GeneID; 41713630; -.
DR KEGG; pfu:PF1811; -.
DR PATRIC; fig|186497.12.peg.1882; -.
DR eggNOG; arCOG04092; Archaea.
DR HOGENOM; CLU_061015_3_0_2; -.
DR OMA; ERMYAFL; -.
DR OrthoDB; 97230at2157; -.
DR PhylomeDB; Q8U012; -.
DR Proteomes; UP000001013; Chromosome.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1440.10; -; 1.
DR HAMAP; MF_01333_A; Ribosomal_L5_A; 1.
DR InterPro; IPR002132; Ribosomal_L5.
DR InterPro; IPR022804; Ribosomal_L5_arc.
DR InterPro; IPR031309; Ribosomal_L5_C.
DR InterPro; IPR022803; Ribosomal_L5_dom_sf.
DR InterPro; IPR031310; Ribosomal_L5_N.
DR PANTHER; PTHR11994; PTHR11994; 1.
DR Pfam; PF00281; Ribosomal_L5; 1.
DR Pfam; PF00673; Ribosomal_L5_C; 1.
DR PIRSF; PIRSF002161; Ribosomal_L5; 1.
DR SUPFAM; SSF55282; SSF55282; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW RNA-binding; rRNA-binding; tRNA-binding.
FT CHAIN 1..186
FT /note="50S ribosomal protein L5"
FT /id="PRO_0000125065"
SQ SEQUENCE 186 AA; 21231 MW; 611DBD95C98F5E20 CRC64;
MAVEIPNKEQ ILADWEAHPM RRPRIEKVTI NIGVGESGER LTKAEIMLQQ LTGQKPIRRK
AKKTNRDFGI RRGEPIAVKV TLRGPKAYEL LKRLLAAVDN RLKASSFDEH GNVCFGIEEH
INIPGVEYDP EIGIFGMDVC VTLERPGFRV ARRKRKRAKI PTRHKLTKEE GMVYMMEEFG
VEIVEG
