ID   AAXA_CHLTR              Reviewed;         461 AA.
AC   O84377;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Porin AaxA;
DE   AltName: Full=Outer membrane protein AaxA;
DE   Flags: Precursor;
GN   Name=aaxA; OrderedLocusNames=CT_372;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- FUNCTION: Facilitates L-arginine uptake, as part of the AaxABC system.
CC       The arginine uptake by the bacterium in the macrophage may be a
CC       virulence factor against the host innate immune response (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OprB family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC67968.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE001273; AAC67968.1; ALT_INIT; Genomic_DNA.
DR   PIR; E71523; E71523.
DR   RefSeq; NP_219881.1; NC_000117.1.
DR   AlphaFoldDB; O84377; -.
DR   STRING; 813.O172_02035; -.
DR   EnsemblBacteria; AAC67968; AAC67968; CT_372.
DR   GeneID; 884743; -.
DR   KEGG; ctr:CT_372; -.
DR   PATRIC; fig|272561.5.peg.401; -.
DR   HOGENOM; CLU_619231_0_0_0; -.
DR   OMA; SQTFPGD; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.160.180; -; 1.
DR   InterPro; IPR007049; Carb-sel_porin_OprB.
DR   InterPro; IPR038673; OprB_sf.
DR   Pfam; PF04966; OprB; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell outer membrane; Ion transport; Membrane; Porin;
KW   Reference proteome; Signal; Transmembrane; Transmembrane beta strand;
KW   Transport; Virulence.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..461
FT                   /note="Porin AaxA"
FT                   /id="PRO_0000363184"
SQ   SEQUENCE   461 AA;  51470 MW;  28CDB5D85C97C958 CRC64;
     MSFRSVLLTA LLSLSFTTTM QAAHHHYHRY TDKLHRQNHK KDLISPKPTE QEACNTSSLS
     KELIPLSEQR GLLSPICDFI SERPCLHGVS VRNLKQALKN SAGTQIALDW SILPQWFNPR
     VSHAPKLSIR DFGYSAHQTV TEATPPCWQN CFNPSAAVTI YDSSYGKGVF QISYTLVRYW
     RENAATAGDA MMLAGSINDY PSRQNIFSQF TFSQNFPNER VSLTIGQYSL YAIDGTLYNN
     DQQLGFISYA LSQNPTATYS SGSLGAYLQV APTASTSLQI GFQDAYNISG SSIKWSNLTK
     NRYNFHGFAS WAPRCCLGSG QYSVLLYVTR QVPEQMEQTM GWSVNASQHI SSKLYVFGRY
     SGVTGHVFPI NRTYSFGMAS ANLFNRNPQD LFGIACAFNN VHLSASPNTK RKYETVIEGF
     ATIGCGPYLS FAPDFQLYLY PALRPNKQSA RVYSVRANLA I