ID   RL5_TETTS               Reviewed;         301 AA.
AC   Q231U7;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 2.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=60S ribosomal protein L5;
GN   Name=RPL5; ORFNames=TTHERM_00736480;
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210;
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (3.52 ANGSTROMS) OF 60S RIBOSOME.
RX   PubMed=22052974; DOI=10.1126/science.1211204;
RA   Klinge S., Voigts-Hoffmann F., Leibundgut M., Arpagaus S., Ban N.;
RT   "Crystal structure of the eukaryotic 60S ribosomal subunit in complex with
RT   initiation factor 6.";
RL   Science 334:941-948(2011).
CC   -!- FUNCTION: Component of the ribosome, a large ribonucleoprotein complex
CC       responsible for the synthesis of proteins in the cell. The small
CC       ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the
CC       encoded message by selecting cognate aminoacyl-transfer RNA (tRNA)
CC       molecules. The large subunit (LSU) contains the ribosomal catalytic
CC       site termed the peptidyl transferase center (PTC), which catalyzes the
CC       formation of peptide bonds, thereby polymerizing the amino acids
CC       delivered by tRNAs into a polypeptide chain. The nascent polypeptides
CC       leave the ribosome through a tunnel in the LSU and interact with
CC       protein factors that function in enzymatic processing, targeting, and
CC       the membrane insertion of nascent chains at the exit of the ribosomal
CC       tunnel. {ECO:0000250|UniProtKB:P26321}.
CC   -!- SUBUNIT: Component of the large ribosomal subunit (LSU).
CC       {ECO:0000250|UniProtKB:P26321}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P26321}. Nucleus
CC       {ECO:0000250|UniProtKB:P26321}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL18 family.
CC       {ECO:0000305}.
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DR   EMBL; GG662786; EAR91353.2; -; Genomic_DNA.
DR   RefSeq; XP_001011598.2; XM_001011598.2.
DR   PDB; 4V8P; X-ray; 3.52 A; BM/CM/EM/GM=1-301.
DR   PDBsum; 4V8P; -.
DR   AlphaFoldDB; Q231U7; -.
DR   SMR; Q231U7; -.
DR   IntAct; Q231U7; 1.
DR   STRING; 5911.EAR91353; -.
DR   GeneID; 7823307; -.
DR   KEGG; tet:TTHERM_00736480; -.
DR   eggNOG; KOG0875; Eukaryota.
DR   InParanoid; Q231U7; -.
DR   OrthoDB; 999609at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0008097; F:5S rRNA binding; IEA:InterPro.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   HAMAP; MF_01337_A; Ribosomal_L18_A; 1.
DR   InterPro; IPR005485; Rbsml_L5_euk/L18_arc.
DR   InterPro; IPR025607; Rbsml_L5e_C.
DR   PANTHER; PTHR23410; PTHR23410; 1.
DR   Pfam; PF14204; Ribosomal_L18_c; 1.
DR   Pfam; PF17144; Ribosomal_L5e; 1.
DR   PRINTS; PR00058; RIBOSOMALL5.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Nucleus; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein; RNA-binding; rRNA-binding.
FT   CHAIN           1..301
FT                   /note="60S ribosomal protein L5"
FT                   /id="PRO_0000413491"
FT   REGION          257..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   301 AA;  34454 MW;  AF27B3D68534C6BC CRC64;
     MGFVKVLKTK AYFKRFQTKY RRRREGLTDY YARKRLIIQD KDKYNTPKYR LVARATNTRI
     IAQIVYATLK CDRVLCAADS YELKRFGVST GLASYAAAYA TGLLLARRLL KQIGLDTVYA
     GQTKVDGAYF NVDEDQKEKK PFKAILDAGL VRTTTGNRVF GVLKGACDGG INIPHSESRF
     PGYVRASDEG ESSKYKPEDH KARIFGKHID AYMKHLKGQS NEAFQKQFSK WSKTLEAAKV
     DSVEKLFTKV HAEIRKNPER VKSTKKNDKP KRDHKKFYPT KLTAAQRKDR VKTKFQLALS
     Q