RL5_THEMA
ID RL5_THEMA Reviewed; 184 AA.
AC P38517;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=50S ribosomal protein L5 {ECO:0000255|HAMAP-Rule:MF_01333};
GN Name=rplE {ECO:0000255|HAMAP-Rule:MF_01333}; OrderedLocusNames=TM_1488;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=8002596; DOI=10.1128/jb.176.24.7703-7710.1994;
RA Sanangelantoni A.M., Bocchetta M., Cammarano P., Tiboni O.;
RT "Phylogenetic depth of S10 and spc operons: cloning and sequencing of a
RT ribosomal protein gene cluster from the extremely thermophilic bacterium
RT Thermotoga maritima.";
RL J. Bacteriol. 176:7703-7710(1994).
RN [2]
RP SEQUENCE REVISION TO 158.
RA Sanangelantoni A.M.;
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
CC -!- FUNCTION: This is 1 of the proteins that binds and probably mediates
CC the attachment of the 5S RNA into the large ribosomal subunit, where it
CC forms part of the central protuberance. In the 70S ribosome it contacts
CC protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits;
CC this bridge is implicated in subunit movement. Contacts the P site
CC tRNA; the 5S rRNA and some of its associated proteins might help
CC stabilize positioning of ribosome-bound tRNAs. {ECO:0000255|HAMAP-
CC Rule:MF_01333}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit; part of the 5S
CC rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA.
CC Forms a bridge to the 30S subunit in the 70S ribosome.
CC {ECO:0000255|HAMAP-Rule:MF_01333}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL5 family.
CC {ECO:0000255|HAMAP-Rule:MF_01333}.
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DR EMBL; Z21677; CAA79789.1; -; Genomic_DNA.
DR EMBL; AE000512; AAD36554.1; -; Genomic_DNA.
DR PIR; H72248; H72248.
DR RefSeq; NP_229288.1; NC_000853.1.
DR RefSeq; WP_004081811.1; NZ_CP011107.1.
DR AlphaFoldDB; P38517; -.
DR SMR; P38517; -.
DR STRING; 243274.THEMA_06860; -.
DR EnsemblBacteria; AAD36554; AAD36554; TM_1488.
DR KEGG; tma:TM1488; -.
DR eggNOG; COG0094; Bacteria.
DR InParanoid; P38517; -.
DR OMA; ERMYAFL; -.
DR OrthoDB; 1456375at2; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1440.10; -; 1.
DR HAMAP; MF_01333_B; Ribosomal_L5_B; 1.
DR InterPro; IPR002132; Ribosomal_L5.
DR InterPro; IPR020930; Ribosomal_L5_bac-type.
DR InterPro; IPR031309; Ribosomal_L5_C.
DR InterPro; IPR020929; Ribosomal_L5_CS.
DR InterPro; IPR022803; Ribosomal_L5_dom_sf.
DR InterPro; IPR031310; Ribosomal_L5_N.
DR PANTHER; PTHR11994; PTHR11994; 1.
DR Pfam; PF00281; Ribosomal_L5; 1.
DR Pfam; PF00673; Ribosomal_L5_C; 1.
DR PIRSF; PIRSF002161; Ribosomal_L5; 1.
DR SUPFAM; SSF55282; SSF55282; 1.
DR PROSITE; PS00358; RIBOSOMAL_L5; 1.
PE 3: Inferred from homology;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding;
KW rRNA-binding; tRNA-binding.
FT CHAIN 1..184
FT /note="50S ribosomal protein L5"
FT /id="PRO_0000125012"
FT CONFLICT 24
FT /note="F -> L (in Ref. 1; CAA79789)"
FT /evidence="ECO:0000305"
FT CONFLICT 102
FT /note="N -> S (in Ref. 1; CAA79789)"
FT /evidence="ECO:0000305"
FT CONFLICT 146
FT /note="N -> D (in Ref. 1; CAA79789)"
FT /evidence="ECO:0000305"
FT CONFLICT 170
FT /note="A -> V (in Ref. 1; CAA79789)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 184 AA; 21306 MW; 52702CB5A4513989 CRC64;
MRYEYVPLKD QYEKEIVPAL MKEFNYKNIH QVPKLVKIVI NMGIGEGSRN YDLIERHANE
LAKITGQKPI VTRARKSISN FKIRKGMPIG LKVTLRGARM YNFLYKLINI VLPKVRDFRG
LDPNSFDGRG NYSFGLSEQL VFPELNPDEV RRIQGMDITI VTTAKTDQEA RRLLELFGMP
FKRG
