RL6_BACSU
ID RL6_BACSU Reviewed; 179 AA.
AC P46898;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=50S ribosomal protein L6 {ECO:0000255|HAMAP-Rule:MF_01365};
DE AltName: Full=BL10;
GN Name=rplF {ECO:0000255|HAMAP-Rule:MF_01365}; OrderedLocusNames=BSU01310;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC 3610 / NRRL NRS-744 / VKM B-501;
RX PubMed=8635744; DOI=10.1016/0378-1119(95)00757-1;
RA Suh J.-W., Boylan S.A., Oh S.H., Price C.W.;
RT "Genetic and transcriptional organization of the Bacillus subtilis spc-
RT alpha region.";
RL Gene 169:17-23(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=8969501; DOI=10.1099/13500872-142-11-3039;
RA Yasumoto K., Liu H., Jeong S.M., Ohashi Y., Kakinuma S., Tanaka K.,
RA Kawamura F., Yoshikawa H., Takahashi H.;
RT "Sequence analysis of a 50 kb region between spo0H and rrnH on the Bacillus
RT subtilis chromosome.";
RL Microbiology 142:3039-3046(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [4] {ECO:0007744|PDB:6HA1, ECO:0007744|PDB:6HA8}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS) OF 1-179 WITH AND WITHOUT
RP VIRGINIAMYCIN M.
RX PubMed=30126986; DOI=10.1073/pnas.1808535115;
RA Crowe-McAuliffe C., Graf M., Huter P., Takada H., Abdelshahid M.,
RA Novacek J., Murina V., Atkinson G.C., Hauryliuk V., Wilson D.N.;
RT "Structural basis for antibiotic resistance mediated by the Bacillus
RT subtilis ABCF ATPase VmlR.";
RL Proc. Natl. Acad. Sci. U.S.A. 115:8978-8983(2018).
CC -!- FUNCTION: This protein binds to the 23S rRNA, and is important in its
CC secondary structure. It is located near the subunit interface in the
CC base of the L7/L12 stalk, and near the tRNA binding site of the
CC peptidyltransferase center. {ECO:0000255|HAMAP-Rule:MF_01365}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit.
CC {ECO:0000269|PubMed:30126986}.
CC -!- INTERACTION:
CC P46898; P38424: engB; NbExp=2; IntAct=EBI-6401129, EBI-6401087;
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL6 family.
CC {ECO:0000255|HAMAP-Rule:MF_01365}.
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DR EMBL; L47971; AAB06814.1; -; Genomic_DNA.
DR EMBL; D64125; BAA10981.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB11907.1; -; Genomic_DNA.
DR PIR; B69695; B69695.
DR RefSeq; NP_388012.1; NC_000964.3.
DR RefSeq; WP_004399690.1; NZ_JNCM01000029.1.
DR PDB; 3J3V; EM; 13.30 A; G=1-179.
DR PDB; 3J3W; EM; 10.70 A; G=1-179.
DR PDB; 3J9W; EM; 3.90 A; BH=1-179.
DR PDB; 5NJT; EM; 3.80 A; a=2-176.
DR PDB; 6HA1; EM; 3.10 A; G=1-179.
DR PDB; 6HA8; EM; 3.50 A; G=1-179.
DR PDB; 6HTQ; EM; 4.50 A; G=2-176.
DR PDB; 6PPK; EM; 4.40 A; G=1-179.
DR PDB; 6TNN; EM; 3.07 A; a=1-179.
DR PDB; 6TPQ; EM; 3.07 A; a=1-179.
DR PDB; 7AQC; EM; 2.99 A; G=1-179.
DR PDB; 7AQD; EM; 3.10 A; G=1-179.
DR PDB; 7AS8; EM; 2.90 A; I=1-179.
DR PDB; 7AS9; EM; 3.50 A; I=1-179.
DR PDB; 7O5B; EM; 3.33 A; d=1-179.
DR PDB; 7OPE; EM; 3.20 A; I=1-179.
DR PDB; 7QV1; EM; 3.50 A; G=1-179.
DR PDB; 7QV2; EM; 3.50 A; G=1-179.
DR PDB; 7QV3; EM; 5.14 A; G=1-179.
DR PDBsum; 3J3V; -.
DR PDBsum; 3J3W; -.
DR PDBsum; 3J9W; -.
DR PDBsum; 5NJT; -.
DR PDBsum; 6HA1; -.
DR PDBsum; 6HA8; -.
DR PDBsum; 6HTQ; -.
DR PDBsum; 6PPK; -.
DR PDBsum; 6TNN; -.
DR PDBsum; 6TPQ; -.
DR PDBsum; 7AQC; -.
DR PDBsum; 7AQD; -.
DR PDBsum; 7AS8; -.
DR PDBsum; 7AS9; -.
DR PDBsum; 7O5B; -.
DR PDBsum; 7OPE; -.
DR PDBsum; 7QV1; -.
DR PDBsum; 7QV2; -.
DR PDBsum; 7QV3; -.
DR AlphaFoldDB; P46898; -.
DR SMR; P46898; -.
DR IntAct; P46898; 2.
DR STRING; 224308.BSU01310; -.
DR jPOST; P46898; -.
DR PaxDb; P46898; -.
DR PRIDE; P46898; -.
DR EnsemblBacteria; CAB11907; CAB11907; BSU_01310.
DR GeneID; 938229; -.
DR KEGG; bsu:BSU01310; -.
DR PATRIC; fig|224308.179.peg.134; -.
DR eggNOG; COG0097; Bacteria.
DR InParanoid; P46898; -.
DR OMA; KPDPYKG; -.
DR PhylomeDB; P46898; -.
DR BioCyc; BSUB:BSU01310-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR Gene3D; 3.90.930.12; -; 2.
DR HAMAP; MF_01365_B; Ribosomal_L6_B; 1.
DR InterPro; IPR000702; Ribosomal_L6.
DR InterPro; IPR020040; Ribosomal_L6_a/b-dom.
DR InterPro; IPR036789; Ribosomal_L6_a/b-dom_sf.
DR InterPro; IPR019906; Ribosomal_L6_bac-type.
DR InterPro; IPR002358; Ribosomal_L6_CS.
DR PANTHER; PTHR11655; PTHR11655; 1.
DR PANTHER; PTHR11655:SF14; PTHR11655:SF14; 1.
DR Pfam; PF00347; Ribosomal_L6; 2.
DR PIRSF; PIRSF002162; Ribosomal_L6; 1.
DR PRINTS; PR00059; RIBOSOMALL6.
DR SUPFAM; SSF56053; SSF56053; 2.
DR TIGRFAMs; TIGR03654; L6_bact; 1.
DR PROSITE; PS00525; RIBOSOMAL_L6_1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW RNA-binding; rRNA-binding.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..179
FT /note="50S ribosomal protein L6"
FT /id="PRO_0000131038"
FT TURN 4..6
FT /evidence="ECO:0007829|PDB:7AQC"
FT STRAND 16..19
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 21..23
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 25..28
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 33..36
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 42..47
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 50..54
FT /evidence="ECO:0007829|PDB:7AS8"
FT HELIX 60..81
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 84..94
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 96..98
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 103..112
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 114..116
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 123..125
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 127..130
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 132..137
FT /evidence="ECO:0007829|PDB:7AS8"
FT HELIX 139..150
FT /evidence="ECO:0007829|PDB:7AS8"
FT TURN 151..153
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 157..159
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 162..164
FT /evidence="ECO:0007829|PDB:7AS8"
SQ SEQUENCE 179 AA; 19509 MW; C52DC1D1543E377E CRC64;
MSRVGKKLLE IPSDVTVTLN DNNTVAVKGP KGELTRTFHP DMEIKVEDNV LTVARPSDQK
EHRALHGTTR SLLGNMVEGV SKGFERGLEL VGVGYRASKS GNKLVLNVGY SHPVEIVPEE
GIEIEVPSQT KVVVKGTDKE RVGAIAANIR AVRSPEPYKG KGIRYEGEVV RRKEGKSAK
