RL6_BOVIN
ID RL6_BOVIN Reviewed; 287 AA.
AC Q58DQ3; A3KMZ3;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=60S ribosomal protein L6;
GN Name=RPL6;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymphoid epithelium;
RA Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.;
RT "Analysis of sequences obtained from constructed full-length bovine cDNA
RT libraries.";
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal pons;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. {ECO:0000250|UniProtKB:Q02878}.
CC -!- SUBUNIT: Component of the large ribosomal subunit (By similarity). May
CC bind IPO9 with low affinity (By similarity).
CC {ECO:0000250|UniProtKB:P47911, ECO:0000250|UniProtKB:Q02878}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q02878}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q02878}. Rough endoplasmic reticulum
CC {ECO:0000250|UniProtKB:Q2YGT9}. Note=Detected on cytosolic polysomes
CC (By similarity). Detected in ribosomes that are associated with the
CC rough endoplasmic reticulum (By similarity).
CC {ECO:0000250|UniProtKB:Q02878, ECO:0000250|UniProtKB:Q2YGT9}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL6 family.
CC {ECO:0000305}.
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DR EMBL; BT021543; AAX46390.1; -; mRNA.
DR EMBL; BT021544; AAX46391.1; -; mRNA.
DR EMBL; AY911360; AAW82124.1; -; mRNA.
DR EMBL; BC133430; AAI33431.1; -; mRNA.
DR RefSeq; NP_001026926.1; NM_001031756.2.
DR RefSeq; XP_005217842.1; XM_005217785.2.
DR RefSeq; XP_005217843.1; XM_005217786.2.
DR AlphaFoldDB; Q58DQ3; -.
DR SMR; Q58DQ3; -.
DR STRING; 9913.ENSBTAP00000042411; -.
DR PaxDb; Q58DQ3; -.
DR PeptideAtlas; Q58DQ3; -.
DR PRIDE; Q58DQ3; -.
DR Ensembl; ENSBTAT00000033359; ENSBTAP00000042411; ENSBTAG00000031723.
DR GeneID; 511051; -.
DR KEGG; bta:511051; -.
DR CTD; 6128; -.
DR VEuPathDB; HostDB:ENSBTAG00000031723; -.
DR eggNOG; KOG1694; Eukaryota.
DR GeneTree; ENSGT00390000003682; -.
DR HOGENOM; CLU_066767_0_1_1; -.
DR InParanoid; Q58DQ3; -.
DR OMA; KHPLNSY; -.
DR OrthoDB; 1227453at2759; -.
DR TreeFam; TF300115; -.
DR Reactome; R-BTA-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-BTA-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-BTA-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-BTA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-BTA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR Proteomes; UP000009136; Chromosome 17.
DR Bgee; ENSBTAG00000031723; Expressed in adenohypophysis and 107 other tissues.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR GO; GO:0042788; C:polysomal ribosome; ISS:UniProtKB.
DR GO; GO:0005791; C:rough endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0002181; P:cytoplasmic translation; ISS:UniProtKB.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR CDD; cd13156; KOW_RPL6; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR InterPro; IPR000915; 60S_ribosomal_L6E.
DR InterPro; IPR041997; KOW_RPL6.
DR InterPro; IPR014722; Rib_L2_dom2.
DR InterPro; IPR005568; Ribosomal_L6_N.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR10715; PTHR10715; 1.
DR Pfam; PF01159; Ribosomal_L6e; 1.
DR Pfam; PF03868; Ribosomal_L6e_N; 1.
DR SUPFAM; SSF50104; SSF50104; 1.
DR PROSITE; PS01170; RIBOSOMAL_L6E; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Endoplasmic reticulum; Isopeptide bond;
KW Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Ubl conjugation.
FT CHAIN 1..287
FT /note="60S ribosomal protein L6"
FT /id="PRO_0000171007"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..44
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 93
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:P47911"
FT MOD_RES 126
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q02878"
FT MOD_RES 206
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:P47911"
FT MOD_RES 238
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q02878"
FT CROSSLNK 5
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q02878"
SQ SEQUENCE 287 AA; 32690 MW; D3546817AB51C143 CRC64;
MAGEKAEKPD TKEKKPEAKK ADAGKKAKKV EKVKKVKKGK PHCSRNPVLV RGIGRYSRSA
MYSRKALYKR KYSAAKSKVE KKKKVRVLAT VTKPVGGDKN GGTRVVKLRK MPRYYPTEDV
PRKLLSHGKK PFSKHVRKLR ASITPGTILI ILTGRHRGKR VVFLKQLGSG LLLVTGPLSL
NRVPLRRTHQ KFVIATSTKI DISGVKIPEH LTDTYFKKKK LRKPRHQEGE IFDTEREKYE
ITEQRKVDQK AVDSQILRRI KAVPQLQGYL RSVFALTNGI YPHKVVF
