ID   RL6_CAEEL               Reviewed;         217 AA.
AC   P47991;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=60S ribosomal protein L6;
GN   Name=rpl-6; ORFNames=R151.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Component of the large ribosomal subunit.
CC       {ECO:0000250|UniProtKB:Q02878}.
CC   -!- SUBUNIT: Component of the large ribosomal subunit (By similarity). May
CC       bind IPO9 with low affinity (By similarity).
CC       {ECO:0000250|UniProtKB:P47911, ECO:0000250|UniProtKB:Q02878}.
CC   -!- INTERACTION:
CC       P47991; Q11184: let-756; NbExp=3; IntAct=EBI-316106, EBI-3843983;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q02878}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q02878}. Rough endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q2YGT9}. Note=Detected on cytosolic polysomes
CC       (By similarity). Detected in ribosomes that are associated with the
CC       rough endoplasmic reticulum (By similarity).
CC       {ECO:0000250|UniProtKB:Q02878, ECO:0000250|UniProtKB:Q2YGT9}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL6 family.
CC       {ECO:0000305}.
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DR   EMBL; FO081317; CCD70755.1; -; Genomic_DNA.
DR   PIR; T16762; T16762.
DR   RefSeq; NP_498584.1; NM_066183.3.
DR   AlphaFoldDB; P47991; -.
DR   SMR; P47991; -.
DR   BioGRID; 41227; 93.
DR   DIP; DIP-26565N; -.
DR   IntAct; P47991; 1.
DR   STRING; 6239.R151.3.2; -.
DR   iPTMnet; P47991; -.
DR   EPD; P47991; -.
DR   PaxDb; P47991; -.
DR   PeptideAtlas; P47991; -.
DR   EnsemblMetazoa; R151.3.1; R151.3.1; WBGene00004417.
DR   GeneID; 176015; -.
DR   KEGG; cel:CELE_R151.3; -.
DR   UCSC; R151.3.1; c. elegans.
DR   CTD; 176015; -.
DR   WormBase; R151.3; CE00744; WBGene00004417; rpl-6.
DR   eggNOG; KOG1694; Eukaryota.
DR   GeneTree; ENSGT00390000003682; -.
DR   HOGENOM; CLU_066767_0_0_1; -.
DR   InParanoid; P47991; -.
DR   OMA; GPYEVNG; -.
DR   OrthoDB; 1227453at2759; -.
DR   PhylomeDB; P47991; -.
DR   Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-CEL-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-CEL-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-CEL-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-CEL-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:P47991; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00004417; Expressed in larva and 4 other tissues.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0005791; C:rough endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   GO; GO:0008340; P:determination of adult lifespan; IMP:WormBase.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR   CDD; cd13156; KOW_RPL6; 1.
DR   Gene3D; 2.30.30.30; -; 1.
DR   InterPro; IPR000915; 60S_ribosomal_L6E.
DR   InterPro; IPR041997; KOW_RPL6.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   PANTHER; PTHR10715; PTHR10715; 1.
DR   Pfam; PF01159; Ribosomal_L6e; 1.
DR   SUPFAM; SSF50104; SSF50104; 1.
DR   PROSITE; PS01170; RIBOSOMAL_L6E; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Endoplasmic reticulum; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein.
FT   CHAIN           1..217
FT                   /note="60S ribosomal protein L6"
FT                   /id="PRO_0000171013"
SQ   SEQUENCE   217 AA;  24313 MW;  5BA7FE473B1C239B CRC64;
     MVGKRNLPVI SRNFDLSPGV LRFSASRLRL KKGEKKPKFT KDTSAKLPKL QRNGTKFALG
     HSKTVTLRKT LTPGTVLIVL AGRHKGKRVV FLKQLPQSGL LLVTGPHKIN GFPLRRIGQA
     FVIATSLKVN VSGVKIPEHI NDEYFKRKST AQKTGKNIFA SGKTEYTVSE QRKKDIKTVD
     APILAAIKKH PEHKFLFGYL GTRFSLGKNQ YPHKMQF