RL6_PIG
ID RL6_PIG Reviewed; 284 AA.
AC Q2YGT9;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=60S ribosomal protein L6;
GN Name=RPL6;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Wang H.L., Zhu Z.M., Wu X., Wang H., Yu M., Zhao S.H., Yang S.L., Li K.;
RT "Full-length cDNA, molecular characterization, and physical mapping of
RT porcine RPL6, RPL7 and RPL10.";
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0007744|PDB:3J7O, ECO:0007744|PDB:3J7P}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), FUNCTION, SUBCELLULAR
RP LOCATION, AND SUBUNIT.
RX PubMed=24930395; DOI=10.1016/j.cell.2014.05.024;
RA Voorhees R.M., Fernandez I.S., Scheres S.H., Hegde R.S.;
RT "Structure of the mammalian ribosome-Sec61 complex to 3.4 A resolution.";
RL Cell 157:1632-1643(2014).
CC -!- FUNCTION: Component of the large ribosomal subunit (PubMed:24930395).
CC The ribosome is a large ribonucleoprotein complex responsible for the
CC synthesis of proteins in the cell (PubMed:24930395).
CC {ECO:0000269|PubMed:24930395}.
CC -!- SUBUNIT: Component of the large ribosomal subunit (PubMed:24930395).
CC May bind IPO9 with low affinity (By similarity).
CC {ECO:0000250|UniProtKB:P47911, ECO:0000269|PubMed:24930395}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q02878}. Cytoplasm
CC {ECO:0000269|PubMed:24930395}. Rough endoplasmic reticulum
CC {ECO:0000269|PubMed:24930395}. Note=Detected on cytosolic polysomes (By
CC similarity). Detected in ribosomes that are associated with the rough
CC endoplasmic reticulum (PubMed:24930395). {ECO:0000250|UniProtKB:Q02878,
CC ECO:0000269|PubMed:24930395}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL6 family.
CC {ECO:0000305}.
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DR EMBL; AY735452; AAV85770.1; -; mRNA.
DR RefSeq; NP_001038007.1; NM_001044542.1.
DR PDB; 3J7O; EM; 3.40 A; E=38-284.
DR PDB; 3J7P; EM; 3.50 A; E=38-284.
DR PDB; 3J7Q; EM; 3.50 A; E=38-284.
DR PDB; 3J7R; EM; 3.90 A; E=38-284.
DR PDBsum; 3J7O; -.
DR PDBsum; 3J7P; -.
DR PDBsum; 3J7Q; -.
DR PDBsum; 3J7R; -.
DR AlphaFoldDB; Q2YGT9; -.
DR SMR; Q2YGT9; -.
DR STRING; 9823.ENSSSCP00000020107; -.
DR PaxDb; Q2YGT9; -.
DR PeptideAtlas; Q2YGT9; -.
DR PRIDE; Q2YGT9; -.
DR Ensembl; ENSSSCT00005063051; ENSSSCP00005038974; ENSSSCG00005039246.
DR Ensembl; ENSSSCT00040065197; ENSSSCP00040027596; ENSSSCG00040048288.
DR Ensembl; ENSSSCT00045019331; ENSSSCP00045013258; ENSSSCG00045011389.
DR Ensembl; ENSSSCT00050052859; ENSSSCP00050022195; ENSSSCG00050039189.
DR Ensembl; ENSSSCT00070016991; ENSSSCP00070014063; ENSSSCG00070008766.
DR Ensembl; ENSSSCT00070016998; ENSSSCP00070014069; ENSSSCG00070008766.
DR GeneID; 733592; -.
DR KEGG; ssc:733592; -.
DR CTD; 6128; -.
DR eggNOG; KOG1694; Eukaryota.
DR HOGENOM; CLU_066767_0_1_1; -.
DR InParanoid; Q2YGT9; -.
DR OMA; WAREKKD; -.
DR OrthoDB; 1227453at2759; -.
DR TreeFam; TF300115; -.
DR Reactome; R-SSC-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-SSC-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-SSC-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-SSC-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-SSC-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-SSC-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Chromosome 14.
DR Genevisible; Q2YGT9; SS.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:Ensembl.
DR GO; GO:0098556; C:cytoplasmic side of rough endoplasmic reticulum membrane; IDA:UniProtKB.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0015934; C:large ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0042788; C:polysomal ribosome; ISS:UniProtKB.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0002181; P:cytoplasmic translation; ISS:UniProtKB.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR CDD; cd13156; KOW_RPL6; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR InterPro; IPR000915; 60S_ribosomal_L6E.
DR InterPro; IPR041997; KOW_RPL6.
DR InterPro; IPR014722; Rib_L2_dom2.
DR InterPro; IPR005568; Ribosomal_L6_N.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR10715; PTHR10715; 1.
DR Pfam; PF01159; Ribosomal_L6e; 1.
DR Pfam; PF03868; Ribosomal_L6e_N; 1.
DR SUPFAM; SSF50104; SSF50104; 1.
DR PROSITE; PS01170; RIBOSOMAL_L6E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cytoplasm; Endoplasmic reticulum;
KW Isopeptide bond; Phosphoprotein; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; Ubl conjugation.
FT CHAIN 1..284
FT /note="60S ribosomal protein L6"
FT /id="PRO_0000171011"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..41
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 90
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:P47911"
FT MOD_RES 123
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q02878"
FT MOD_RES 203
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:P47911"
FT MOD_RES 235
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q02878"
FT CROSSLNK 5
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q02878"
SQ SEQUENCE 284 AA; 32190 MW; FA94DFCA7306AE2F CRC64;
MAGEKAEKPG TKEKKPEAKK ADAGGKVKKA KKVKKGKPHC SRNPVLVRGI GRYSRSAMYS
RKALYKRKYS AAKSKVEKKK KVRVLATVTK PVGGDKNGGT RVVKLRKMPR YYPTEDVPRK
LLSHGKKPFS KHVRKLRASI TPGTILIILT GRHRGKRVIF LKQLSSGLLL VTGPLSLNRV
PLRRTHQKFV IATSTKIDIS GVKIPEHLTD AYFKKKKLRK PRHQEGEIFD TEKEKYEISE
QRKVDQKAVD SQILRRIKAV PQLQGYLRSV FALTNGIYPH KLVF
